公开(公告)号：KR1020030035974A

公开(公告)日：2003-05-09

申请号：KR1020020065744

申请日：2002-10-28

Applicant: 한국과학기술연구원

Inventor： 이용섭 ,  박호군 ,  진창배 ,  김형자 ,  조정숙 ,  박미정 ,  송윤선

IPC: A61K36/33 ,  A61P25/28 ,  A61P9/10 ,  A61P9/00

CPC classification number: A61K31/352 ,  A61K36/33

Abstract: PURPOSE: A composition containing an extract of Opuntia ficus-indica var. Saboten Makino and a compound isolated therefrom which exhibit antioxidative action and nerve cell protecting activity is provided. The composition inhibits neurotoxicity caused by cell death and exhibits nerve cell protecting effect on animal models of brain ischemia and is thus expected to be useful for prevention and treatment of cerebral apoplexy, cerebral concussion, Alzheimer's disease, Parkinson's disease, myocardial infarction and brain infarction. CONSTITUTION: A composition for protecting nerve cells contains an ethyl acetate extract of Opuntia ficus-indica and a compound isolated from therefrom as an active ingredient. The ethyl acetate extract contains campherol, dihydroquercetin or quercetin-3-methyl ether as an active ingredient and is prepared by adding 0.1 to 10L of an alcohol solvent to stems, fruits or processed fruits of Opuntia ficus-indica, followed by leaving them at room temperature for 4 to 5 days, filtering, distilling under reduced pressure and then extracting with 0.5 to 2L of ethyl acetate.

Abstract translation: 目的：一种含有仙人掌提取物的组合物。 提供了Saboten Makino和从其分离的化合物，其显示出抗氧化作用和神经细胞保护活性。 该组合物抑制由细胞死亡引起的神经毒性，并且对脑缺血动物模型显示神经细胞保护作用，因此预期可用于预防和治疗脑中风，脑震荡，阿尔茨海默氏病，帕金森病，心肌梗死和脑梗死。 构成：用于保护神经细胞的组合物含有榕属仙茅的乙酸乙酯萃取物和从其分离的化合物作为活性成分。 乙酸乙酯提取物含有荆芥，二氢槲皮素或槲皮素-3-甲醚作为活性成分，并通过向榕树芸苔的茎，果实或加工水果中加入0.1至10L的醇溶剂，然后将其留在室内 温度4〜5天，过滤，减压蒸馏，然后用0.5〜2L乙酸乙酯萃取。

公开(公告)号：KR1020020068586A

公开(公告)日：2002-08-28

申请号：KR1020010008668

申请日：2001-02-21

Applicant: 박은희 ,  한국과학기술연구원

Inventor： 송윤선 ,  진창배 ,  허강민 ,  이용섭 ,  이재열 ,  박은희

IPC: A61K35/644 ,  A61K9/00 ,  A61K9/70

CPC classification number: A61K35/644 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/7023

Abstract: PURPOSE: A new use of propolis and caffeic acid phenethyl(CAPE) ester as a component thereof is provided. Therefore, the propolis and CAPE can be used as a preventive and therapeutic agent for a disease generated from estrogen deficiency, or nitric oxide inhibitors, angiogenesis inhibitors. CONSTITUTION: An estrogen agonist contains propolis and caffeic acid phenethyl ester as an effective component, and an estrogen agonist composition is obtained by adding a pharmaceutically acceptable conventional excipient, carrier or adjuvant to the propolis and CAPE. The composition contains one formulation of: powder, a tablet, capsule, liquid and dispersing agent; a patch agent for mucosal absorption or transdermal absorption; and an injection.

Abstract translation: 目的：提供蜂胶和咖啡酸苯乙酯（CAPE）酯作为其成分的新用途。 因此，蜂胶和CAPE可用作由雌激素缺乏症或一氧化氮抑制剂，血管发生抑制剂产生的疾病的预防和治疗剂。 构成：雌激素激动剂含有蜂胶和咖啡酸苯乙酯作为有效成分，通过向蜂胶和CAPE中加入药学上可接受的常规赋形剂，载体或佐剂来获得雌激素激动剂组合物。 该组合物含有以下制剂：粉剂，片剂，胶囊，液体和分散剂; 用于粘膜吸收或经皮吸收的贴剂; 和注射。

公开(公告)号：KR100543897B1

公开(公告)日：2006-01-23

申请号：KR1020030036482

申请日：2003-06-05

Applicant: 한국과학기술연구원

Inventor： 이용섭 ,  진창배 ,  이재열 ,  김형자 ,  서선희 ,  송윤선

IPC: A61K31/70

Abstract: 본 발명은 활성산소 소거활성 및 항바이러스활성을 가지는 치자 추출물, 그로부터 분리된 신규한 화합물 및 그 용도에 관한 것이다. 보다 상세하게는 물 또는 유기용매로 추출되며, 유효성분으로 메틸 5-
O -카페오일-4-
O -시나포일퀴네이트, 메틸 3,5-
O -디카페오일-4-
O -(3-히드록시-3-메틸)글루타로일퀴네이트, 에틸 5-
O -카페오일-4-
O -시나포일퀴네이트, 메틸 3-
O -카페오일-5-
O -시나포일퀴네이트, 에틸 3-
O -카페오일-5-
O -시나포일퀴네이트, 3,5-
O - 디카페오일퀴닉산 및 4,5-
O -디카페오일퀴닉산을 포함하는 활성산소소거활성 및 항바이러스활성을 나타내는 치자추출물. 그로부터 분리된 신규 화합물에 관한 것이다.
본 발명에 의한 치자 추출물 및 분리된 신규화합물들은 DPPH 자유라디칼, 슈퍼옥사이드 음이온 라디칼 등의 활성산소 소거활성이 우수하여 활성 산소에 의한 질병을 치료 및 예방하는데 뛰어난 효과가 있으며, 인간면역결핍바이러스의 인티그라제에 대한 저해 활성 및 항바이러스활성도 높아 AIDS 등 바이러스성 질환의 치료에 응용될 수 있다.
치자, 활성산소 소거활성, 인티그라제(integrase), 항바이러스활성, AIDS,

公开(公告)号：KR100523562B1

公开(公告)日：2005-10-25

申请号：KR1020020065744

申请日：2002-10-28

Applicant: 한국과학기술연구원

Inventor： 이용섭 ,  박호군 ,  진창배 ,  김형자 ,  조정숙 ,  박미정 ,  송윤선

IPC: A61K36/33 ,  A61P25/28 ,  A61P9/10 ,  A61P9/00

CPC classification number: A61K31/352 ,  A61K36/33

Abstract: 본 발명은 손바닥선인장을 에틸 아세테이트로 추출하여 얻은 신경세포 보호효과를 갖는 추출물 및, 이 추출물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 신경세포 보호용 약학 조성물에 관한 것으로, 본 발명의 약학 조성물은 알쯔하이머병, 뇌졸중, 파킨슨병과 같은 뇌신경질환에 의한 뇌신경세포 손상, 허혈로 인한 세포와 조직 손상 또는 심근경색과 같은 심혈관계 질환의 예방 및 치료에 유용하게 사용될 수 있다.

公开(公告)号：KR100420498B1

公开(公告)日：2004-03-04

申请号：KR1020010008668

申请日：2001-02-21

Applicant: 박은희 ,  한국과학기술연구원

Inventor： 송윤선 ,  진창배 ,  허강민 ,  이용섭 ,  이재열 ,  박은희

IPC: A61K35/644 ,  A61K9/00 ,  A61K9/70

Abstract: PURPOSE: A new use of propolis and caffeic acid phenethyl(CAPE) ester as a component thereof is provided. Therefore, the propolis and CAPE can be used as a preventive and therapeutic agent for a disease generated from estrogen deficiency, or nitric oxide inhibitors, angiogenesis inhibitors. CONSTITUTION: An estrogen agonist contains propolis and caffeic acid phenethyl ester as an effective component, and an estrogen agonist composition is obtained by adding a pharmaceutically acceptable conventional excipient, carrier or adjuvant to the propolis and CAPE. The composition contains one formulation of: powder, a tablet, capsule, liquid and dispersing agent; a patch agent for mucosal absorption or transdermal absorption; and an injection.

Abstract translation: 目的：提供蜂胶和咖啡酸苯乙酯（CAPE）酯作为其组分的新用途。 因此，蜂胶和CAPE可以用作由雌激素缺乏症或一氧化氮抑制剂，血管生成抑制剂产生的疾病的预防和治疗剂。 组成：雌激素激动剂含有蜂胶和咖啡酸苯乙酯作为有效成分，并且通过向蜂胶和CAPE中加入药学上可接受的常规赋形剂，载体或佐剂获得雌激素激动剂组合物。 该组合物含有一种制剂：粉末，片剂，胶囊，液体和分散剂; 用于粘膜吸收或透皮吸收的贴剂; 和注射。

公开(公告)号：KR1020040105183A

公开(公告)日：2004-12-14

申请号：KR1020030036482

申请日：2003-06-05

Applicant: 한국과학기술연구원

Inventor： 이용섭 ,  진창배 ,  이재열 ,  김형자 ,  서선희 ,  송윤선

IPC: A61K31/70

CPC classification number: A61K36/744 ,  A23L33/105 ,  A61K8/97 ,  A61K2236/33 ,  A61K2800/522 ,  A61Q19/08

Abstract: PURPOSE: Provided are the Gardeniae fructus extract having free radical scavenging activity and antiviral activity, novel compounds isolated therefrom and the use thereof for prevention and treatment of viral diseases, such as AIDS. CONSTITUTION: The Gardeniae fructus extract is obtained by extracting Gardeniae fructus with water or organic solvents. It contains as an active ingredent, methyl-0-caffeoyl-4-0-sinapolylquinate, methyl 3,5-0-dicarffeoyl-4-0-(3-hydroxy-3-methyl)glutaroylquinate, ethyl 5-0-caffeoyl-4-0-sinapoylquinate, methyl -0-caffeoyl--0-sinapoylquinate, ethyl 3-0-caffeoyl-5-0-sinapoylquinate, 3,5-0-dicaffeoylquinic acid, and 4,5-0-dicaffeoylquinic acid.

Abstract translation: 目的：提供具有自由基清除活性和抗病毒活性的栀子提取物，从其中分离的新化合物及其用于预防和治疗病毒性疾病如AIDS的用途。 构成：栀子提取物通过用水或有机溶剂萃取栀子获得。 它含有作为活性成分的甲基O-咖啡酰基-4-0-辛酰基喹喔啉，3,5-0-二甲酰基-4-0-（3-羟基-3-甲基）戊酰基喹啉甲基，5-0-咖啡酰基 - 4-0-辛酰基喹喔啉，O-咖啡酰基-O-辛酰基喹喔啉，3-0-咖啡酰基-5-0-辛酰基喹喔啉，3,5-0-二苯甲酰奎宁酸，和4,5-0-二茄酸奎宁酸。