公开(公告)号：KR1019880009927A

公开(公告)日：1988-10-05

申请号：KR1019870000857

申请日：1987-02-03

Applicant: 한국과학기술연구원

Inventor： 이기정 ,  박호군 ,  김중협 ,  엄현숙

IPC: C07D211/08

Abstract: 내용 없음.

公开(公告)号：KR1019900002052B1

公开(公告)日：1990-03-31

申请号：KR1019870000857

申请日：1987-02-03

Applicant: 한국과학기술연구원

Inventor： 이기정 ,  박호군 ,  김중협 ,  엄현숙

IPC: C07D211/08

Abstract: The method for preparing piperidine derivatives of formula (I) useful for the antihistaminic agent is presented. Thus, 37.7g of ethylisonipecotate, 35.0g of potassium hydrogen carbonate, 52.5g of 4-chloro-p-t-butylbutyropenone and a small amount of potassium iodine are added to 800ml of toluene and the above mixture is reacted for 24 hrs. The above reacted solution is cooled to room temperature and added with 300ml of water to the cooled solution. The obtained water layer is extracted with 300ml of toluene twice and the extract is dried.

Abstract translation: 提出了制备用于抗组胺剂的式（I）哌啶衍生物的方法。 因此，向800ml甲苯中加入37.7g异哌啶酸乙酯，35.0g碳酸氢钾，52.5g 4-氯 - 对 - 叔丁基丁烯酮和少量碘化钾，使上述混合物反应24小时。 将上述反应的溶液冷却至室温，并向冷却的溶液中加入300ml水。 将得到的水层用300ml甲苯萃取2次，萃取液干燥。