中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

15 records (took 0.018 seconds)

    실리카겔 지지체에 결합된 트리플루오로메틸케톤 유도체 및 그의 제조방법
    1.
    发明公开
    실리카겔 지지체에 결합된 트리플루오로메틸케톤 유도체 및 그의 제조방법 失效
    支持二氧化硅凝胶的三氟甲基酮衍生物及其制备方法

    公开(公告)号：KR1020010008779A

    公开(公告)日：2001-02-05

    申请号：KR1019990026769

    申请日：1999-07-03

    Applicant: 한국과학기술연구원

    Inventor： 송충의 ,  임진석 ,  노은주 ,  이기정 ,  지대윤

    IPC: C07G5/00

    CPC classification number: C07C49/167 ,  C07B2200/11

    Abstract: PURPOSE: The trifluoromethylketone derivatives supported on silica gel and a producing method thereof are provided to be used as a useful catalyst in the epoxidation reaction using olefin and Oxone oxidizing agent. CONSTITUTION: The trifluoromethylketone derivatives are represented by formula (3), in which R1 is C1 to C6 alkyl, R2, R3 and R4 are individually hydrogen or C1 to C6 alkyl, I is an integer from 0 to 1, m is methylene from 1 to 6, n is an integer from 0 to 2, and O is methylene from 0 to 16. The trifluoromethylketone derivatives of formula (3) supported on silica gel are produced by reacting trifluoromethylketone derivatives of formula (1) with mercaptoalkylsilanized silica gel of formula (2) in the presence of organic solvents such as azobisisobutyronitrile, benzene, toluene, acetonitrile or chloroform.

    Abstract translation: 目的：提供负载在硅胶上的三氟甲基酮衍生物及其制备方法，用作使用烯烃和氧化羰氧化剂的环氧化反应中的有用催化剂。 构成：三氟甲基酮衍生物由式（3）表示，其中R 1为C 1至C 6烷基，R 2，R 3和R 4各自为氢或C 1至C 6烷基，I为0至1的整数，m为1 至6，n为0至2的整数，O为0至16的亚甲基。通过使式（1）的三氟甲基酮衍生物与式（1）的巯基烷基硅烷化硅胶与式 （2）在有机溶剂如偶氮二异丁腈，苯，甲苯，乙腈或氯仿存在下进行。

    세팔로스포린 유도체 및 그의 제조방법
    4.
    发明授权
    세팔로스포린 유도체 및 그의 제조방법 失效
    CEPHALOSPORIN衍生物

    公开(公告)号：KR1019930001114B1

    公开(公告)日：1993-02-18

    申请号：KR1019900011089

    申请日：1990-07-20

    Applicant: 한국과학기술연구원

    Inventor： 이기정 ,  최대옥 ,  정재욱

    IPC: C07D501/36

    Abstract: 7- Acylamino-3-(5- methoxythiazolin-2-yl) thiomethyl-3-cephem carboxylic acid derivs. of formula(I) are new. In (I), R=H, 2- (2aminothiazol-4-yl)-2(syn)- methoxyiminoacetyl, 2-(2- aminothiazol - 4-yl)-2-(2-t- butoxycarbonyl-2- propyloxyimino) acetyl, 2- (2aminothiazol-4-yl)-2-(2-carboxy-2-propyloxyimino)acetyl or D(-) alpha-(4- ethyl-2,3- dioxo-1- piperazine carboxyamido)-alpha- (4hydroxyphenyl)acetyl; R'=H or paramethoxybenzyl (PMB). Also claimed is the prepn. of (I) which comprises cyclizing dithiocarbamate of formula (II) in acidic condition and acylating the obtd. intermediate with an acetate deriv.

    Abstract translation: 7-酰氨基-3-（5-甲氧基噻唑啉-2-基）硫甲基-3-头孢烯羧酸衍生物。 式（I）的化合物是新的。 在（I）中，R = H，2-（2-氨基噻唑-4-基）-2（顺式） - 甲氧基亚氨基乙酰基，2-（2-氨基噻唑-4-基）-2-（2-叔丁氧基羰基-2-丙氧基亚氨基 ）乙酰基，2-（2-氨基噻唑-4-基）-2-（2-羧基-2-丙氧基亚氨基）乙酰基或D（ - ）α-（4-乙基-2,3-二氧代-1-哌嗪羧酰胺基）-α - （4-羟基苯基）乙酰基; R'= H或对甲氧基苄基（PMB）。 还声称是prepn。 （I）的方法，其包括在酸性条件下使式（II）的二硫代氨基甲酸酯环化并酰化所述有机物。 中间体与乙酸酯衍生物。

    티아졸린 유도체 및 그의 제조방법
    9.
    发明授权
    티아졸린 유도체 및 그의 제조방법 失效
    噻唑衍生物及其方法

    公开(公告)号：KR1019920008615B1

    公开(公告)日：1992-10-02

    申请号：KR1019900010721

    申请日：1990-07-14

    Applicant: 한국과학기술연구원

    Inventor： 이기정 ,  최대옥 ,  정재욱 ,  박호군

    IPC: C07D277/16

    Abstract: 5-Alkoxy-2-substd. thio-1,3-thiazoline derivs. of formula (I) are new. Also claimed is the prepn. of (I) which comprises a heat- transfer reaction of dithiocarbamate of formula (II) under the condition of 1-5 mmHg and 200 ± 10 deg.C or a cyclization-reaction of (II) under acidic condition. In the formulas, R=H, C1-6 alkyl, allyl, 2-propinyl, benzyl or 2- piridylmethyl; R1= methyl or ethyl. Pref. the acid is selected from trifluoroborane, anhydrous magnesium bromide or conc. H2SO4.

    Abstract translation: 5-烷氧基-2- substd。 硫代-1,3-噻唑啉衍生物。 式（I）的化合物是新的。 还声称是prepn。 （I）的方法，其包括在1-5mmHg和200±10℃的条件下或式（II）在酸性条件下的环化反应的式（II）的二硫代氨基甲酸酯的热转移反应。 式中R = H，C 1-6烷基，烯丙基，2-丙炔基，苄基或2-吡啶基甲基; R1 =甲基或乙基。 县。 酸选自三氟硼烷，无水溴化镁或浓缩。 H2SO4。

    피페리딘 유도체의 제조방법
    10.
    发明授权
    피페리딘 유도체의 제조방법 无效
    制备哌啶衍生物的方法

    公开(公告)号：KR1019900002052B1

    公开(公告)日：1990-03-31

    申请号：KR1019870000857

    申请日：1987-02-03

    Applicant: 한국과학기술연구원

    Inventor： 이기정 ,  박호군 ,  김중협 ,  엄현숙

    IPC: C07D211/08

    Abstract: The method for preparing piperidine derivatives of formula (I) useful for the antihistaminic agent is presented. Thus, 37.7g of ethylisonipecotate, 35.0g of potassium hydrogen carbonate, 52.5g of 4-chloro-p-t-butylbutyropenone and a small amount of potassium iodine are added to 800ml of toluene and the above mixture is reacted for 24 hrs. The above reacted solution is cooled to room temperature and added with 300ml of water to the cooled solution. The obtained water layer is extracted with 300ml of toluene twice and the extract is dried.

    Abstract translation: 提出了制备用于抗组胺剂的式（I）哌啶衍生物的方法。 因此，向800ml甲苯中加入37.7g异哌啶酸乙酯，35.0g碳酸氢钾，52.5g 4-氯 - 对 - 叔丁基丁烯酮和少量碘化钾，使上述混合物反应24小时。 将上述反应的溶液冷却至室温，并向冷却的溶液中加入300ml水。 将得到的水层用300ml甲苯萃取2次，萃取液干燥。

Patent Agency Ranking