베타-아밀로이드 피브릴 형성 저해 효능을 갖는 스티릴벤조퓨란 화합물 및 이의 제조 방법
    7.
    发明公开
    베타-아밀로이드 피브릴 형성 저해 효능을 갖는 스티릴벤조퓨란 화합물 및 이의 제조 방법 失效
    作为抗坏血酸纤维素形成的抑制剂的苯乙烯苯并呋喃衍生物及其制备方法

    公开(公告)号:KR1020090129377A

    公开(公告)日:2009-12-16

    申请号:KR1020090052245

    申请日:2009-06-12

    CPC classification number: C07D307/81 C07D307/80

    Abstract: PURPOSE: A pharmaceutical composition containing styrylbenzofuran compound is provided to ensure suppression efficiency of beta amyloid fibril formation. CONSTITUTION: A styrylbenzofuran compound is denoted by chemical formula 1. A compound of chemical formula 1 is obtained through Honer-Emmons reaction of a compound of chemical formula 2 with a compound of chemical formula 3 and alkali under the presence of organic solvent. The alkali is hydride of alkali metal, alkyl alkali metal compound, alkoxide compound of alkali metal or alkali metal amide compound. The organic solvent is ether organic solvent. A product thorugh Honer-Emmons reaction is demethylated using boron trichloride, boron trifluoride, boron tribromide or iodotrimethylsilane.

    Abstract translation: 目的:提供含有苯乙烯基苯并呋喃化合物的药物组合物,以确保β-淀粉样蛋白原纤维形成的抑制效率。 组成:苯乙烯基苯并呋喃化合物由化学式1表示。化学式1的化合物通过化学式2的化合物与化学式3的化合物和碱在有机溶剂的存在下的Hon-Emmons反应获得。 碱是碱金属的氢化物,烷基碱金属化合物,碱金属或碱金属酰胺化合物的醇盐化合物。 有机溶剂为醚有机溶剂。 使用三氯化硼,三氟化硼,三溴化硼或碘代三甲基硅烷将Honer-Emmons反应产物脱甲基化。

    베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를가지는 이소인돌론 화합물 및 이의 제조 방법
    8.
    发明公开
    베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를가지는 이소인돌론 화합물 및 이의 제조 방법 失效
    具有高结合亲和力的β-β亚甲基聚糖和纤维素及其制备方法

    公开(公告)号:KR1020090042579A

    公开(公告)日:2009-04-30

    申请号:KR1020070108420

    申请日:2007-10-26

    CPC classification number: C07D209/46 C07D209/48

    Abstract: An Isoindolone compound showing excellent binding affinity to beta-Amyloid fibril is provided to treat and prevent degenerative brain diseases by inhibiting generation of beta-Amyloid fibril. A pharmaceutical composition comprises an Isoindolone compound represented by the formula 1 or pharmaceutically allowable salts. In the formula 1, A is C=O or CH2; R1 is a halogen atom selected among H, OH, F, Br and I, a substituted C1-C8 alkoxy group or a C1-C8 alkylamino group, of which the substituted group is selected among a C1-C8 alkyl group, a C1-C8 alkoxy group, a tosyloxy-C1-C8 alkoxy group, a mesyloxy-C1-C8 alkoxy group, a nosyloxy-C1-C8 alkoxy group, H, OH, F, Br and I; R2 is a C1-C8 alkyl group or a halogen atom selected among H, OH, F, Br and I; and R3 and R4 are independently H, a C1-C8 alkoxy group or a C1-C8 alkylamino group.

    Abstract translation: 提供了对β-淀粉样蛋白原纤维显示出优异结合亲和力的异吲哚酮化合物,通过抑制β-淀粉样蛋白原纤维的产生来治疗和预防退行性脑疾病。 药物组合物包含由式1表示的异吲哚酮化合物或其药学上可允许的盐。 在式1中,A为C = O或CH 2; R1是选自H,OH,F,Br和I中的卤素原子,取代的C1-C8烷氧基或C1-C8烷基氨基,其取代基选自C1-C8烷基,C1- C8烷氧基,甲苯磺酰氧基-C1-C8烷氧基,甲磺酰氧基-C1-C8烷氧基,Nosyloxy-C1-C8烷氧基,H,OH,F,Br和I; R2是C1-C8烷基或选自H,OH,F,Br和I中的卤素原子; 且R 3和R 4独立地为H,C 1 -C 8烷氧基或C 1 -C 8烷基氨基。

    유기물과 금속의 복합체
    9.
    发明授权
    유기물과 금속의 복합체 有权
    有机材料和金属复合物

    公开(公告)号:KR101669981B1

    公开(公告)日:2016-10-27

    申请号:KR1020150007541

    申请日:2015-01-15

    Abstract: 본발명은유기물기판, 상기유기물기판위에적층된금속박막을포함하며, 상기금속박막에전자빔이조사된것을특징으로하는유기물과금속의복합체에관한것이다. 본발명의일 실시예에따르면, 상기유기물은폴리이미드이고, 상기금속박막은구리이다. 또한, 본발명의일 실시예에따르면, 상기유기물기판과금속박막사이에은(Ag) 박막이개재되어있는것을특징으로한다. 이러한본 발명에따른유기물과금속의복합체는유기물기판과금속박막의접착특성이개선되며, 이에따라인장특성이매우우수하다.

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