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    항암활성을 지닌 카르보아졸계 화합물
    1.
    发明公开
    항암활성을 지닌 카르보아졸계 화합물 有权
    具有抗癌活性的新型咔唑类化合物

    公开(公告)号：KR1020120056684A

    公开(公告)日：2012-06-04

    申请号：KR1020100118341

    申请日：2010-11-25

    Applicant: 한국과학기술연구원

    Inventor： 배애님 ,  최민정 ,  남길수 ,  조용서 ,  추현아

    IPC: C07D413/06 ,  C07D413/14 ,  A61K31/496 ,  A61P35/00

    Abstract: PURPOSE: A carboazole-based compounds with an anticancer activity and a method for preparing the same are provided to prevent and treat cancer. CONSTITUTION: A carboazole-based compound with an anticancer activity is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the carboazole-based compounds of chemical formula 1. A method for preparing the carboazole-based compounds comprises: a step of reacting amidation of heterocyclic compounds of chemical formula III with 4-haloazole compounds of chemical formula IV to prepare a 4-halocaboazole-based compound of chemical formula V; and a step of performing Suzuki coupling of the compound of chemical formula V with a boronic acid compound of chemical formula VI.

    Abstract translation: 目的：提供具有抗癌活性的基于咔唑的化合物及其制备方法，以预防和治疗癌症。 构成：具有抗癌活性的基于唑的化合物由化学式1表示。用于抗癌的药物组合物含有化学式1的咔唑类化合物。一种制备该类咔唑类化合物的方法包括：使酰胺化反应 的化学式III的4-卤唑化合物的化学式III的杂环化合物，以制备化学式V的4-卤代咔唑类化合物; 以及化学式V化合物与化学式VI的硼酸化合物的Suzuki偶联的步骤。

    ＧＳＫ-3 억제활성을 보이는 1Ｈ-인다졸 화합물
    2.
    发明公开
    ＧＳＫ-3 억제활성을 보이는 1Ｈ-인다졸 화합물 有权
    具有GSK-3抑制活性的1H-吲唑化合物

    公开(公告)号：KR1020120038033A

    公开(公告)日：2012-04-23

    申请号：KR1020100097910

    申请日：2010-10-07

    Applicant: 한국과학기술연구원 ,  서울대학교산학협력단

    Inventor： 배애님 ,  남길수 ,  추현아 ,  조용서 ,  최민정

    IPC: C07D231/56 ,  C07D413/14 ,  A61K31/416 ,  A61P3/10

    Abstract: PURPOSE: A 1H-indazole compound with GSK3 inhibition and pharmaceutically acceptable salt thereof are provided to be used as a therapeutic agent for treating diseases caused by GSK-3 activation. CONSTITUTION: A 1H-indazole compounds is denoted by chemical formula 1. A method for preparing the compound comprises: a step of performing amidation of 3-amino-1H-indazole compounds of chemical formula 2 and a substituted carboxylic acid compound of chemical formula 3 under the presence of pyridine base and 1-ethyl-3-(3'-dimethyl aminopropyl)carbodiimide hydrochloride(EDCI).

    Abstract translation: 目的：提供具有GSK3抑制的1H-吲唑化合物及其药学上可接受的盐作为治疗由GSK-3激活引起的疾病的治疗剂。 构成：1H-吲唑化合物由化学式1表示。一种制备化合物的方法包括：进行化学式2的3-氨基-1H-吲唑化合物和化学式3的取代的羧酸化合物的酰胺化步骤 在吡啶碱和1-乙基-3-（3'-二甲基氨基丙基）碳二亚胺盐酸盐（EDCI）的存在下。

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