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    소목 추출물 및 이로부터 분리된 화합물의 용도
    2.
    发明授权
    소목 추출물 및 이로부터 분리된 화합물의 용도 有权
    使用Caesalpinia sappan L.提取物及其化合物

    公开(公告)号：KR100750657B1

    公开(公告)日：2007-08-20

    申请号：KR1020050120666

    申请日：2005-12-09

    Applicant: 한국과학기술연구원

    Inventor： 양현옥 ,  김민영 ,  권영근 ,  최연희

    IPC: A61K36/48 ,  A61P35/00

    CPC classification number: A61K36/48 ,  A23L33/105 ,  A61K2300/00

    Abstract: 본 발명은 혈관신생(angiogenesis) 억제 활성을 가지는 소목 추출물 및 이로부터 분리된 화합물의 용도에 관한 것으로서, 보다 상세하게는 물, 알콜 또는 이들의 혼합물로 추출되는 추출물, 상기 추출물로부터 분리한 브라질린, 사판칼콘, 브라질레인의 혈관신생 억제 용도에 관한 것이다. 본 발명의 소목 추출물 및 이로부터 분리된 화합물은 혈관신생을 억제하는 활성을 가지므로, 혈관 질환, 심혈관계 질환, 안과 질환, 만성 염증성 질환, 피부과 질환, 알츠하이머, 비만 및 암 등의 혈관 신생 관련 질환의 예방 또는 치료에 유용하게 사용될 수 있다.
    혈관신생, 소목, 브라질린, 사판칼콘, 브라질레인, 관절염, 당뇨병성 망막증, 건선, 암

    Ｔ-형 칼슘 채널에 활성을 지닌 신규 다이페닐프로판노일 화합물
    5.
    发明公开
    Ｔ-형 칼슘 채널에 활성을 지닌 신규 다이페닐프로판노일 화합물 有权
    具有T型钙通道活性的新型二苯基丙烯酸酯化合物

    公开(公告)号：KR1020110119045A

    公开(公告)日：2011-11-02

    申请号：KR1020100038514

    申请日：2010-04-26

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  이재균 ,  최연희 ,  배애님 ,  추현아 ,  임혜원 ,  최기현 ,  서선희 ,  송치만

    IPC: C07D241/04 ,  A61K31/495 ,  A61P25/08 ,  A61P9/12

    CPC classification number: Y02P20/55

    Abstract: PURPOSE: A diphenylpropanoyl compound having T-type calcium channel activity is provided to ensure antagonism to a T-type calcium channel and to be used as a therapeutic agent and anticancer agent. CONSTITUTION: A diphenylpropanoyl is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating hypertension, angina, chronic pain, neurogenic pain or cancer contains a compound of chemical formula 1 as an active ingredient. A method for preparing the compound of chemical formula 1 comprises a step of binding a compound of chemical formula 2 with a compound of chemical formula 3.

    Abstract translation: 目的：提供具有T型钙通道活性的二苯基丙酰基化合物，以确保对T型钙通道的拮抗作用，并用作治疗剂和抗癌剂。 构成：二苯基丙酰基由化学式1表示。用于预防和治疗高血压，心绞痛，慢性疼痛，神经源性疼痛或癌症的药物组合物含有化学式1化合物作为活性成分。 制备化学式1的化合物的方法包括将化学式2的化合物与化学式3的化合物结合的步骤。

    소목 추출물 및 이로부터 분리된 화합물의 용도
    6.
    发明公开
    소목 추출물 및 이로부터 분리된 화합물의 용도 有权
    芍药提取物的使用及其化合物

    公开(公告)号：KR1020070060715A

    公开(公告)日：2007-06-13

    申请号：KR1020050120666

    申请日：2005-12-09

    Applicant: 한국과학기술연구원

    Inventor： 양현옥 ,  김민영 ,  권영근 ,  최연희

    IPC: A61K36/48 ,  A61P35/00

    CPC classification number: A61K36/48 ,  A23L33/105 ,  A61K2300/00

    Abstract: Use of the extract of Caesalpinia sappan L. and compounds isolated therefrom is provided to prevent and treat diseases associated with angiogenesis including vascular disease, cardiovascular disease, eye disease, chronic inflammatory disease, skin disease, Alzheimer's disease, obesity and cancer by inhibiting angiogenesis. The extract of Caesalpinia sappan L. is obtained by extracting Caesalpinia sappan L. with water, alcohol or a mixture thereof, and contains brazilin, sappanchalcone and brazilein as active ingredients, wherein the alcohol is C1-C3 lower alcohol. A composition for inhibiting angiogenesis comprises the extract of Caesalpinia sappan L. or at least one compound isolated therefrom selected from brazilin, sappanchalcone and brazilein.

    Abstract translation: 提供Caesalpinia sappan L.的提取物和从其分离的化合物的用途，以通过抑制血管发生来预防和治疗与血管生成相关的疾病，包括血管疾病，心血管疾病，眼病，慢性炎性疾病，皮肤病，阿尔茨海默病，肥胖症和癌症。 Caesalpinia sappan L.的提取物是通过用水，醇或其混合物提取Caesalpinia sappan L.获得的，并且含有巴西，sappanchalcone和brazilein作为活性成分，其中醇是C1-C3低级醇。 用于抑制血管生成的组合物包含来自贝沙门氏菌属（Sesanchalcone）和巴西丁（brazilein）的Caesalpinia sappan L.或至少一种从其分离的化合物的提取物。

    소목으로부터 브라질레인의 대량 제조 방법
    7.
    发明公开
    소목으로부터 브라질레인의 대량 제조 방법 失效
    豌豆OF OF A A A。。。。。。。。。。。。。。。。

    公开(公告)号：KR1020070060714A

    公开(公告)日：2007-06-13

    申请号：KR1020050120665

    申请日：2005-12-09

    Applicant: 한국과학기술연구원

    Inventor： 양현옥 ,  최연희

    IPC: C07D311/78 ,  A61K36/48

    CPC classification number: C07D311/94 ,  Y02P20/544

    Abstract: A mass production method of brazilein from Caesalpinia sappan L. is provided to reduce the time and costs for production of brazilein and obtain high purity of brazilein by eliminating a process of column chromatography and using no expensive chromatography devices, so that the brazilein is produced in the industrial scale. The mass production method of brazilein from Caesalpinia sappan L. comprises the steps of: (1) extracting Caesalpinia sappan L. with water, alcohol or a mixture thereof; (2) concentrating the extract of Caesalpinia sappan L. to obtain crude crystals of Caesalpinia sappan L.; (3) dissolving the crude crystals in alcohol; (4) concentrating the solution of step(3) in a water bath at 30-40 deg.C and 40-180 rpm; and (5) recrystallizing the concentrated solution by evaporating the solution at 15-30 deg.C for 6-72 hours, wherein the alcohol of the steps(1) and (3) is C1-C3 lower alcohol such as methanol; and the alcohol temperature of step(3) is the of 40-64 deg.C.

    Abstract translation: 提供了从Caesalpinia sappan L.的大量生产方法，以减少生产巴西丁的时间和成本，并通过消除柱色谱法和不使用昂贵的色谱装置来获得高纯度的brazilein，从而使得brazilein生产在 工业规模。 来自豌豆沙司的大规模生产方法包括以下步骤：（1）用水，醇或其混合物提取芍药苷; （2）浓缩Caesalpinia sappan L.提取物，得到Caesalpinia sappan L的粗晶。 （3）将粗晶体溶于醇中; （4）将步骤（3）的溶液浓缩在30-40℃和40-180rpm的水浴中; （5）通过在15-30℃下蒸发溶液6-72小时使浓缩溶液重结晶，其中步骤（1）和（3）的醇是C1-C3低级醇如甲醇; 步骤（3）的醇温为40-64℃。

    Ｔ-형 칼슘 채널에 활성을 지닌 피라조일 피페리딘 화합물
    8.
    发明公开
    Ｔ-형 칼슘 채널에 활성을 지닌 피라조일 피페리딘 화합물 有权
    吡唑啉酮化合物作为T型钙通道拮抗剂

    公开(公告)号：KR1020120097287A

    公开(公告)日：2012-09-03

    申请号：KR1020110016787

    申请日：2011-02-24

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  이재균 ,  배애님 ,  임혜원 ,  최기현 ,  서선희 ,  송치만 ,  최연희

    IPC: C07D401/12 ,  A61K31/454 ,  A61P25/00

    Abstract: PURPOSE: A pharmaceutical composition containing pyrazoyl piperidine compounds and pharmaceutically acceptable salt thereof is provided to prevent or treat brain diseases, heard diseases, cancer, and pain. CONSTITUTION: A pyrazoyl piperidine compound is denoted by chemical formula 1. A pharmaceutical composition for treating cerebral diseases, cardiac diseases, cancer, or pain contains the compound of chemical formula 1 as an active ingredient. A method for preparing the compound comprises: a step of reacting piperidine acetate of chemical formula 2 and pyrazole methyl amine of chemical formula 3 of a step of reacting piperidine compound of chemical formula 4 with an aldehyde compound of chemical formula 5 by reduction-amination. [Reference numerals] (AA) Reductive amination

    Abstract translation: 目的：提供含有吡唑基哌啶化合物及其药学上可接受的盐的药物组合物，以预防或治疗脑疾病，听到疾病，癌症和疼痛。 构成：化学式1表示吡唑基哌啶化合物。用于治疗脑疾病，心脏病，癌症或疼痛的药物组合物含有化学式1的化合物作为活性成分。 制备该化合物的方法包括：使化学式2的哌啶乙酸酯与化学式3的吡唑甲胺与化学式4的哌啶化合物与化学式5的醛化合物的还原胺化反应的步骤。 （参考号）（AA）还原胺化

    폴리(3-헥실티오펜) 기반 블록공중합체의 자기조립 구조 제어방법
    10.
    发明公开
    폴리(3-헥실티오펜) 기반 블록공중합체의 자기조립 구조 제어방법 失效
    用于控制聚3-己基噻吩基嵌段共聚物自组装结构的方法

    公开(公告)号：KR1020110046111A

    公开(公告)日：2011-05-04

    申请号：KR1020090102960

    申请日：2009-10-28

    Applicant: 한국과학기술연구원

    Inventor： 백경열 ,  양회창 ,  황승상 ,  최연희 ,  이윤재 ,  오동엽 ,  이한섭

    IPC: C08J5/00 ,  C08L81/02 ,  C08L33/12 ,  H01L31/04

    CPC classification number: H01L51/0043 ,  G03F7/0002 ,  H01L51/0036 ,  H01L51/0541 ,  H01L51/0545 ,  Y02E10/549

    Abstract: PURPOSE: A method for controlling a self-assembled structure of poly(3-hexylthiophene)-based block copolymer is provided to control the self-assembled structure of poly(3-hexylthiophene)-based block copolymer by only simple process of coating a polymer composition consisting of a poly(3-hexylthiophene)-based block copolymer and a solvent on a substrate. CONSTITUTION: A method for controlling a self-assembled structure of poly(3-hexylthiophene)-based block copolymer comprises the steps of: preparing a polymer composition including a solvent and a block copolymer in which a non-conjugated polymer is introduced to a π-conjugated poly(3-hexylthiophene) polymer; and applying the polymer composition to a substrate.

    Abstract translation: 目的：提供一种用于控制聚（3-己基噻吩）基嵌段共聚物的自组装结构的方法，以通过涂布聚合物的简单方法来控制聚（3-己基噻吩）基嵌段共聚物的自组装结构 组合物由基于聚（3-己基噻吩）的嵌段共聚物和溶剂组成。 构成：用于控制聚（3-己基噻吩）基嵌段共聚物的自组装结构的方法包括以下步骤：制备包含溶剂和嵌段共聚物的聚合物组合物，其中将非共轭聚合物引入π 共轭聚（3-己基噻吩）聚合物; 并将聚合物组合物施加到基底上。

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