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    칼슘 채널에 활성을 지닌 신규 피라조일 피페라진 화합물
    3.
    发明公开
    칼슘 채널에 활성을 지닌 신규 피라조일 피페라진 화합물 有权
    吡唑基哌嗪化合物作为钙通道拮抗剂

    公开(公告)号：KR1020120125098A

    公开(公告)日：2012-11-14

    申请号：KR1020110043180

    申请日：2011-05-06

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  배애님 ,  이재균 ,  서선희 ,  송치만 ,  신선미 ,  아미드,압둘와히드

    IPC: C07D403/12 ,  A61K31/496 ,  A61P25/00

    Abstract: PURPOSE: A pyrazolyl piperazine compound with a pharmaceutical activity to a calcium channel and a pharmaceutical composition containing the same are provided to be used as a pharmaceutical composition for preventing or treating diseases of brain diseases, heart diseases, cancer, and pain. CONSTITUTION: A pyrazolyl piperazine compound is denoted by chemical formula 1. The compound of chemical formula 1 is prepared by binding piperazine compounds of chemical formula 2 and chloride compounds of chemical formula 3 under the presence of a base at 20-30 Deg. C. The base includes an organic base such as an amine-based base and an inorganic base. The reaction solvent is dichloromethane, tetrahydrofurane(THF), dimethyl formamide(DMF), dimethyl aceteamide(DMAC), and dioxane. A pharmaceutical composition for preventing brain diseases, cancer, heart diseases, or pain contains the compound of chemical formula 1.

    Abstract translation: 目的：提供对钙通道具有药学活性的吡唑基哌嗪化合物和含有该通道的药物组合物作为预防或治疗脑疾病，心脏病，癌症和疼痛疾病的药物组合物。 构成：化学式1表示吡唑基哌嗪化合物。化学式1的化合物是通过在20-30度的碱存在下将化学式2的哌嗪化合物和化学式3的氯化合物结合而制备的。 C.碱包括有机碱如胺基和无机碱。 反应溶剂为二氯甲烷，四氢呋喃（THF），二甲基甲酰胺（DMF），二甲基乙酰胺（DMAC）和二恶烷。 用于预防脑疾病，癌症，心脏病或疼痛的药物组合物含有化学式1的化合物。

    Ｔ-형 칼슘 채널 길항제로서의 5-(치환된알킬아미노메틸)아이속사졸계 화합물
    7.
    发明公开
    Ｔ-형 칼슘 채널 길항제로서의 5-(치환된알킬아미노메틸)아이속사졸계 화합물 有权
    5-（取代的烷基氨基甲酰基）异噻唑衍生物作为T型钙通道拮抗剂

    公开(公告)号：KR1020120096842A

    公开(公告)日：2012-08-31

    申请号：KR1020110016203

    申请日：2011-02-23

    Applicant: 한국과학기술연구원

    Inventor： 추현아 ,  배애님 ,  조용서 ,  이효선 ,  이지은 ,  조경희 ,  임혜원 ,  서선희 ,  송치만 ,  정혜진 ,  남길수 ,  금교창 ,  김동진 ,  최경일 ,  최기현 ,  이재균 ,  강용구 ,  박웅서 ,  이주현 ,  신선미 ,  아미드,압둘와히드 ,  김영수 ,  민선준

    IPC: C07D413/12 ,  A61K31/496 ,  A61P25/00 ,  A61P9/00

    CPC classification number: C07D413/12

    Abstract: PURPOSE: A 5-(substituted alkylaminomethyl)isoxazole based compound as T-type calcium channel blocker is provided to have excellent activity as an antagonist of T- type calcium ion channel. CONSTITUTION: A 5-(substituted alkylaminomethyl)isoxazole based compound as T-type calcium channel blocker is represented by chemical formula 1. The encephalopathy therapy and for prevention agent selected from epilepsy, depression, Parkinson's disease, dementia, sleep disorder, an agent for cancer treatment and prevention, an agent for heart disease treatment and prevention selected from hypertensive, cardiac arrhythmia, angina, myocardial infarction, congestive heart failure, pharmaceutical composition for alleviating pain selected from neuropathic pain and chronic and acute pain includes a compound represented by chemical formula 1.

    Abstract translation: 目的：提供作为T型钙通道阻滞剂的5-（取代的烷基氨基甲基）异恶唑基化合物作为T-型钙离子通道的拮抗剂具有优异的活性。 构成：以化学式1表示作为T型钙通道阻断剂的5-（取代烷基氨基甲基）异恶唑类化合物。脑病治疗和预防药物选自癫痫，抑郁症，帕金森病，痴呆，睡眠障碍， 癌症治疗和预防，选自高血压，心律失常，心绞痛，心肌梗塞，充血性心力衰竭，减轻选自神经性疼痛和慢性和急性疼痛的疼痛的药物组合物的心脏病治疗和预防剂，包括由化学式 1。

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