公开(公告)号：KR1020090084149A

公开(公告)日：2009-08-05

申请号：KR1020080010155

申请日：2008-01-31

Applicant: 한국과학기술연구원

Inventor： 이창준 ,  노은주 ,  최진규 ,  한경석 ,  박정은 ,  강상수

IPC: A61K31/522 ,  A61K31/52 ,  A61P35/00

CPC classification number: A61K31/522

Abstract: A composition which contains caffeine, its analog, or its pharmaceutically allowable salt is provided to suppress infiltration, metastasis, and proliferation and prevent and/or treat brain cancer. A composition for preventing and treating brain cancer comprises caffeine, caffeine anaolog, or its pharmaceutically allowable salt as an active ingredient. The caffeine, caffeine analog or its pharmaceutically allowable salt has the content of 0.3-30 mM. The daily dose of the composition is 1-5 mg/kg and the composition is administered at one time or several times. The brain cancer is glioma, exothelioma, pituitary adenoma, schwannoma, craniopharyngioma or the congenital brain tumor. The composition selectively block the subtype 3 of activation of inositol-1,4,5-triphosphate receptoer(IP3R).

Abstract translation: 提供含有咖啡因，其类似物或其药学上可允许的盐的组合物以抑制浸润，转移和增殖，并预防和/或治疗脑癌。 用于预防和治疗脑癌的组合物包括咖啡因，咖啡因厌氧菌或其药学上可允许的盐作为活性成分。 咖啡因，咖啡因类似物或其药学上允许的盐的含量为0.3-30mM。 组合物的日剂量为1-5mg / kg，组合物一次或多次施用。 脑癌是神经胶质瘤，外皮瘤，垂体腺瘤，神经鞘瘤，颅咽管瘤或先天性脑瘤。 组合物选择性阻断肌醇-1,4,5-三磷酸盐受体（IP3R）的活化亚型3。

公开(公告)号：KR100980098B1

公开(公告)日：2010-09-03

申请号：KR1020080009377

申请日：2008-01-30

Applicant: 한국과학기술연구원

Inventor： 이창준 ,  우동호 ,  박형주 ,  오수진 ,  한경석

IPC: A61K48/00 ,  A61K31/192

CPC classification number: C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

Abstract: 본 발명은 뉴런 및/또는 성상세포에서의 신경전달물질 방출 조절에 있어서의 음이온 채널, 보다 구체적으로 칼슘 이온에 의하여 활성화되는 음이온 채널 (Ca
2
+ -activated anion cannel, CAAC)의 신규한 용도와 관련된 것으로, CAAC 활성 조절제, CAAC를 포함하는 신경조절물질 방출 조절제, 및 CAAC를 타겟으로 하는 신경조절물질 방출 조절제의 스크리닝 방법을 제공한다.

公开(公告)号：KR1020090084150A

公开(公告)日：2009-08-05

申请号：KR1020080010156

申请日：2008-01-31

Applicant: 한국과학기술연구원

Inventor： 이창준 ,  강상수 ,  한경석 ,  노은주 ,  박재용

IPC: A61K31/522 ,  A61P9/10 ,  A61P13/10 ,  A61P25/00

CPC classification number: A61K31/522

Abstract: A composition for suppressing an inositol 1,4,5-triphosphate receptor subtype III is provided to prevent and treat diseases which is related to calcium ion release. An agent for suppressing a subtype III of inositol-1,4,5-triphosphate receptor comprises one or more among a group of caffeine, 7-isopropyl theophylline, 7-(beta-hydroxyethyl)theophyline, xanthenes, theophyline, 1,7-dimethyl-3-isobutyl xantene and their pharmaceutically allowable salt as active ingredient. A composition for preventing and treating diseases which is related to calcium ion excessive release comprises one or more among caffeine, 7-isopropyl theophyline, 7-(beta-hydroxyethyl)theopyline, xanthene, theophyline, 1,7-dimethyl-3-isobutyl xanthenes and their pharmaceutically allowable salt as active ingredient. The diseases related to calcium ion excessive release is one of stroke, anxiety, hyper sensitive bladder salt, inflammatory bowel disease, irritable colon syndrome, interstitial colitis, head injury, migraine, chronic, the neuropathy nature or the acute pain, the stress disorder after drug or the alcoholism, the neurological failure, psychosis, somnopathy, phobia, compulsion, debit, and the depression, stroma, diabetes, cancer, the male sterilization, hypertension, pulmonary hypertension, cardiac arrhythmia, congestive heart failure, angina, the polycystic kidney disease [autosomal dominant polycystic kidney] and Duchenne muscular dystrophy (DMD).

Abstract translation: 提供抑制肌醇1,4,5-三磷酸受体亚型III的组合物，以预防和治疗与钙离子释放有关的疾病。 用于抑制肌醇-1,4,5-三磷酸受体亚型III的药剂包括一组咖啡因，7-异丙基茶碱，7-（β-羟乙基）茶碱，呫吨酮，茶碱， 二甲基-3-异丁基呫吨及其药学上允许的盐作为活性成分。 用于预防和治疗与钙离子过度释放有关的疾病的组合物包括咖啡因，7-异丙基茶碱，7-（β-羟乙基）麻黄碱，呫吨，茶碱，1,7-二甲基-3-异丁基呫吨的一种或多种 及其药学上可允许的盐作为活性成分。 与钙离子过度释放相关的疾病是中风，焦虑，超敏性膀胱盐，炎性肠病，肠易激综合征，间质性结肠炎，头部损伤，偏头痛，慢性，神经病变或急性疼痛，紧张性疾病 药物或酒精中毒，神经系统衰竭，精神​​病，睡眠障碍，恐惧症，强迫性，借贷和抑郁症，基质，糖尿病，癌症，男性绝育，高血压，肺动脉高压，心律失常，充血性心力衰竭，心绞痛，多囊肾 疾病[常染色体显性多囊肾]和杜氏肌营养不良症（DMD）。

公开(公告)号：KR1020090083532A

公开(公告)日：2009-08-04

申请号：KR1020080009377

申请日：2008-01-30

Applicant: 한국과학기술연구원

Inventor： 이창준 ,  우동호 ,  박형주 ,  오수진 ,  한경석

IPC: A61K48/00 ,  A61K31/192

CPC classification number: C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

Abstract: An agent for controlling the release of neurotransmitter of neuron and/or astrocyte and apply on improving recognition and perception. An agent for regulating the release of excitatory neurotransmitter from a neuron or astrocyte via Ca^2+-activated anion channel(CAAC) comprises a regulator of anion channel which is activated by calcium ion. The anion channel is coded by a bestrophin 1 gene. The excitatory neurotransmitter is acetylcholine asparaginic acid, D-serine, glutamate, enkephalin or histamine. The CAAC agent an antisense RNA or shRNA(short hairpin RNA) to anion channel blocker or CAAC coding nucleotide sequence.

Abstract translation: 用于控制神经元和/或星形胶质细胞的神经递质的释放并用于改善识别和感知的药剂。 通过Ca 2+激活的阴离子通道（CAAC）调节兴奋性神经递质从神经元或星形胶质细胞释放的药剂包含由钙离子激活的阴离子通道的调节剂。 阴离子通道由一个bestrophin 1基因编码。 兴奋性神经递质是乙酰胆碱天冬酰胺酸，D-丝氨酸，谷氨酸，脑啡肽或组胺。 CAAC试剂为阴离子通道阻断剂或CAAC编码核苷酸序列的反义RNA或shRNA（短发夹RNA）。