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    이노시톨 1,4,5-트리포스페이트 수용체 서브타입 3 억제용조성물
    3.
    发明公开
    이노시톨 1,4,5-트리포스페이트 수용체 서브타입 3 억제용조성물 无效
    用于抑制INOSITOL 1,4,5-三磷酸酯受体亚型III活性的组合物

    公开(公告)号：KR1020090084150A

    公开(公告)日：2009-08-05

    申请号：KR1020080010156

    申请日：2008-01-31

    Applicant: 한국과학기술연구원

    Inventor： 이창준 ,  강상수 ,  한경석 ,  노은주 ,  박재용

    IPC: A61K31/522 ,  A61P9/10 ,  A61P13/10 ,  A61P25/00

    CPC classification number: A61K31/522

    Abstract: A composition for suppressing an inositol 1,4,5-triphosphate receptor subtype III is provided to prevent and treat diseases which is related to calcium ion release. An agent for suppressing a subtype III of inositol-1,4,5-triphosphate receptor comprises one or more among a group of caffeine, 7-isopropyl theophylline, 7-(beta-hydroxyethyl)theophyline, xanthenes, theophyline, 1,7-dimethyl-3-isobutyl xantene and their pharmaceutically allowable salt as active ingredient. A composition for preventing and treating diseases which is related to calcium ion excessive release comprises one or more among caffeine, 7-isopropyl theophyline, 7-(beta-hydroxyethyl)theopyline, xanthene, theophyline, 1,7-dimethyl-3-isobutyl xanthenes and their pharmaceutically allowable salt as active ingredient. The diseases related to calcium ion excessive release is one of stroke, anxiety, hyper sensitive bladder salt, inflammatory bowel disease, irritable colon syndrome, interstitial colitis, head injury, migraine, chronic, the neuropathy nature or the acute pain, the stress disorder after drug or the alcoholism, the neurological failure, psychosis, somnopathy, phobia, compulsion, debit, and the depression, stroma, diabetes, cancer, the male sterilization, hypertension, pulmonary hypertension, cardiac arrhythmia, congestive heart failure, angina, the polycystic kidney disease [autosomal dominant polycystic kidney] and Duchenne muscular dystrophy (DMD).

    Abstract translation: 提供抑制肌醇1,4,5-三磷酸受体亚型III的组合物，以预防和治疗与钙离子释放有关的疾病。 用于抑制肌醇-1,4,5-三磷酸受体亚型III的药剂包括一组咖啡因，7-异丙基茶碱，7-（β-羟乙基）茶碱，呫吨酮，茶碱， 二甲基-3-异丁基呫吨及其药学上允许的盐作为活性成分。 用于预防和治疗与钙离子过度释放有关的疾病的组合物包括咖啡因，7-异丙基茶碱，7-（β-羟乙基）麻黄碱，呫吨，茶碱，1,7-二甲基-3-异丁基呫吨的一种或多种 及其药学上可允许的盐作为活性成分。 与钙离子过度释放相关的疾病是中风，焦虑，超敏性膀胱盐，炎性肠病，肠易激综合征，间质性结肠炎，头部损伤，偏头痛，慢性，神经病变或急性疼痛，紧张性疾病 药物或酒精中毒，神经系统衰竭，精神​​病，睡眠障碍，恐惧症，强迫性，借贷和抑郁症，基质，糖尿病，癌症，男性绝育，高血压，肺动脉高压，心律失常，充血性心力衰竭，心绞痛，多囊肾 疾病[常染色体显性多囊肾]和杜氏肌营养不良症（DMD）。

    조현병 동물모델 및 이의 제조방법
    7.
    发明授权
    조현병 동물모델 및 이의 제조방법 有权

    公开(公告)号：KR102217401B1

    公开(公告)日：2021-02-22

    申请号：KR1020200087421

    申请日：2020-07-15

    Applicant: 고려대학교 산학협력단 ,  한국과학기술연구원

    Inventor： 박재용 ,  황은미 ,  임혜인 ,  조장훈 ,  이상준

    IPC: A01K67/027 ,  G01N33/50

    Abstract: 본발명은내측고삐핵의콜린성신경세포에서특이적으로 ANO1(Anoctamin 1) 유전자가결손된생쥐인것을특징으로하는조현병동물모델및 이의제조방법등에관한것이다. 본발명에따른조현병동물모델은조현병발병기전에주요하게작용하는뇌조직인내측고삐핵을표적으로한 것으로서, 내측고삐핵의콜린성신경세포에서 ANO1 유전자가특이적으로결손되는경우조현병의양성증상, 음성증상, 및인지증상이나타남을확인하여조현병이유발됨을확인하였는바, 본발명의동물모델이조현병의발병기전연구, 치료제개발및 스크리닝의동물모델로유용하게이용될것으로기대된다.

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