公开(公告)号：KR1020020005201A

公开(公告)日：2002-01-17

申请号：KR1020000034935

申请日：2000-06-23

Applicant: 한국과학기술연구원 ,  안국바이오진단(주)

Inventor： 한동근 ,  안광덕 ,  김종만 ,  주영민

IPC: C08J9/26

CPC classification number: C08J9/08 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  C08J9/28 ,  C08J2201/048 ,  C08J2367/04 ,  Y10S514/802 ,  Y10S514/945 ,  Y10S514/955 ,  C08L67/04

Abstract: PURPOSE: A biodegradable porous polymer supporter for the tissue engineering and its preparation method are provided, to obtain the open cell-structured porous polymer supporter with an improved degree of pore and to allow the size of pore to be controlled. CONSTITUTION: The biodegradable porous polymer supporter is prepared by making a polymer species by using a polymer solution containing a biodegradable polymer and an anisotropic mixture; boiling(foaming) the polymer species in a boiling medium; and drying it. Preferably the biodegradable polymer is selected from the group consisting of poly(glycolic acid), poly(lactic acid), poly(lactic acid-glycolic acid) copolymer, poly(ε-caprolactone), poly(amic acid), polyanhydride, poly(ortho-ester), their derivatives, and their mixtures; and has a molecular weight of 5,000-2,000,000. The anisotropic mixture comprises a carbonate and an organic acid. Preferably the carbonate is selected from the group consisting of sodium hydrogen carbonate, sodium carbonate, ammonium hydrogen carbonate, ammonium carbonate, potassium hydrogen carbonate, potassium carbonate, calcium carbonate, and their mixtures; and the organic acid is selected from the group consisting of citric acid, succinic acid, tartaric acid, succinic acid, maleic acid, fumaric acid, malonic acid, malic acid, gluconic acid, mucic acid, some amino acids and their mixtures.

Abstract translation: 目的：提供用于组织工程的生物可降解多孔聚合物支持体及其制备方法，以获得具有改善的孔隙度并允许控制孔的尺寸的开孔细胞结构的多孔聚合物支持体。 构成：通过使用含有可生物降解聚合物和各向异性混合物的聚合物溶液制备聚合物物质来制备可生物降解的多孔聚合物载体; 在沸腾介质中沸腾（发泡）聚合物物质; 并干燥。 优选地，生物可降解聚合物选自聚（乙醇酸），聚（乳酸），聚（乳酸 - 乙醇酸）共聚物，聚（ε-己内酯），聚（酰胺酸），聚酐，聚（ 原酸酯），它们的衍生物及其混合物; 并具有5,000-2,000,000的分子量。 各向异性混合物包含碳酸盐和有机酸。 优选碳酸盐选自碳酸氢钠，碳酸钠，碳酸氢铵，碳酸铵，碳酸氢钾，碳酸钾，碳酸钙及其混合物; 有机酸选自柠檬酸，琥珀酸，酒石酸，琥珀酸，马来酸，富马酸，丙二酸，苹果酸，葡萄糖酸，粘酸，一些氨基酸及其混合物。

公开(公告)号：KR100355563B1

公开(公告)日：2002-10-11

申请号：KR1020000034935

申请日：2000-06-23

Applicant: 한국과학기술연구원 ,  안국바이오진단(주)

Inventor： 한동근 ,  안광덕 ,  김종만 ,  주영민

IPC: C08J9/26

Abstract: 본 발명은 조직공학용 생분해성의 다공성 고분자 지지체의 제조방법에 관한 것으로서, 상기 방법은 생분해성 고분자와 비등성 혼합물이 함께 함유된 고분자용액을 이용하여 고분자 시편을 만든 다음 알콜 혼합수용액과 같은 비등 매질 하에서 비등(발포)하고 건조하는 단계를 포함한다.
본 발명은 또한 상기 방법에 의해 제조된 조직공학용 생분해성의 다공성 고분자 지지체에 관한 것으로서, 상기 생분해성의 다공성 고분자 지지체는 기공의 크기의 조절이 용이하고 다공도가 높으며 기공간 상호 연결되어 있는 연속 기포 구조(open cell structure)를 갖는 것을 특징으로 한다.
본 발명에 따른 생분해성의 다공성 고분자 지지체 및 그 제조방법은 기존의 고분자 지지체(scaffold)의 제조시 일반적으로 적용해온 염 침출법 (salt leaching technique)과 가스 발포법 (gas foaming technique)에 의해 발생하는 지지체 표면의 다공성 막힘 현상, 복잡한 제조과정 및 유해 물질의 분비 및 잔존 현상을 해결할 수 있는 대체 방안임과 아울러 거의 모든 조직 및 장기를 조직공학적으로 재생할 수 있다는 장점으로 가지고 있다.

公开(公告)号：KR100367042B1

公开(公告)日：2003-01-15

申请号：KR1019990046512

申请日：1999-10-26

Applicant: 한국과학기술연구원

Inventor： 안광덕 ,  김종만 ,  한동근 ,  강종희

IPC: C07C50/18

CPC classification number: Y02P20/55

Abstract: PURPOSE: A method for forming a fine fluorescent image by using protected hydroxy group-containing anthraquinone derivatives or naphthacenequinone derivatives is provided. Thereby the obtained protected hydroxy group-containing compound can be applied to recording material and censor material because it can easily form a fine fluorescent image of micrometer units under the condition of a chemically amplified fine image forming process. CONSTITUTION: This method comprises the steps of: preparing a transparent solution by dissolving protected hydroxy group-containing anthraquinone derivatives of formula 1 or naphthacenequinone derivatives of formula 2 and a soluble polymer in an organic solvent; forming a thin film by coating the solution on a substrate; prebaking the thin film coated substrate; and removing a hydroxy protecting group of the anthraquinone derivatives or naphthacenequinone derivatives by treating under the condition of a chemically amplified fine image forming process.

Abstract translation: 目的：提供一种通过使用被保护的含羟基蒽醌衍生物或并四苯醌衍生物来形成精细荧光图像的方法。 因此，所获得的被保护的含羟基化合物可以应用于记录材料和传感材料，因为它可以在化学放大的精细图像形成过程的条件下容易地形成微米单位的精细荧光图像。 构成：该方法包括以下步骤：通过将式1的受保护的含羟基蒽醌衍生物或式2的萘并萘醌衍生物和可溶性聚合物溶解在有机溶剂中制备透明溶液; 通过将溶液涂覆在基底上形成薄膜; 预烘烤薄膜涂覆的基材; 并通过在化学放大的精细图像形成过程的条件下处理除去蒽醌衍生物或萘并萘醌衍生物的羟基保护基。

公开(公告)号：KR100351074B1

公开(公告)日：2002-09-05

申请号：KR1020000038132

申请日：2000-07-05

Applicant: 한국과학기술연구원 ,  주식회사 덴키스트

Inventor： 한동근 ,  안광덕 ,  김종만 ,  정진희

IPC: A61K6/00

Abstract: 본 발명은 종래 치과수복용 프리폴리머로 사용되고 있는 2,2-비스-(4-(2-히드록시-3-메타크릴로일옥시프로폭시)페닐)프로판 [이하, "Bis-GMA"라 명명함]에, 이 Bis-GMA 분자 중의 히드록시기의 수소 원자를 메타크릴레이트기로 치환한 멀티메타크릴레이트기 함유 다관능성 프리폴리머를 혼합한 프리폴리머 혼합물을 기재로 하고, 희석제, 무기 충전제, 광개시계 및 기타 첨가제를 포함하는 치과수복용 광중합성 복합레진 조성물에 관한 것이다. 다관능성 프리폴리머 혼합물을 기재로 하는 본 발명의 치과수복용 광중합성 복합레진 조성물은 기재로서 Bis-GMA 자체만을 포함하는 종래의 것보다 우수한 물리적, 기계적 특성과 생체 적합성을 나타낸다.

公开(公告)号：KR100341426B1

公开(公告)日：2002-06-21

申请号：KR1019990046511

申请日：1999-10-26

Applicant: 한국과학기술연구원

Inventor： 안광덕 ,  김종만 ,  한동근 ,  강종희

IPC: C07C50/16

CPC classification number: Y02P20/55

Abstract: 본발명은미세형광화상형성용재료의전구물질로서유용한히드록시보호된 1,4-디히드록시안트라퀴논유도체및 그의공중합체와, 이공중합체를이용한미세형광화상형성방법에관한것이다. 본발명의히드록시보호된 1,4-디히드록시안트라퀴논공중합체는히드록시기의분자내수소결합을한시적으로차단한다음, 산, 열또는광 등에의해탈보호되어색 및형광의변화를일으키기때문에, 화학증폭성미세화상형성공정조건에서쉽게미크론미터단위의미세형광화상을형성할수 있어서, 색화상및 형광화상물질과같은기록용재료, 그리고센서재료로응용될수 있다.

公开(公告)号：KR100324644B1

公开(公告)日：2002-02-27

申请号：KR1019990046513

申请日：1999-10-26

Applicant: 한국과학기술연구원

Inventor： 안광덕 ,  김종만 ,  한동근 ,  강종희

IPC: C07C15/28

Abstract: 본발명은미세형광화상형성용재료의전구물질로서유용한, α-아미노안트라센유도체및 그의공중합체와, 이공중합체를이용한미세형광화상형성방법에관한것이다. 본발명의α-아미노안트라센함유공중합체는유기산또는무기산에의해형광이변하고, 광산발생제와혼합하여박막상태에서노광할경우쉽게미크론미터단위의미세형광화상을형성할수 있으며, 용액, 필름및 입자상태에서센서기능이우수하여기록용재료및 센서재료로응용될수 있다.

公开(公告)号：KR100321563B1

公开(公告)日：2002-01-23

申请号：KR1019990046514

申请日：1999-10-26

Applicant: 한국과학기술연구원

Inventor： 안광덕 ,  김종만 ,  박기홍 ,  한동근

IPC: C07D263/54

Abstract: 본발명은미세형광화상형성용재료의전구물질로서유용한, 피리딜벤족사졸유도체및 그의공중합체와, 이공중합체를이용한미세형광화상형성방법에관한것이다. 본발명의피리딜벤족사졸함유공중합체는유기산또는무기산, 또는금속이온에의해형광이변하고, 광산발생제와혼합하여박막상태에서노광할경우쉽게미크론미터단위의미세형광화상을형성할수 있으며, 용액, 필름및 입자상태에서센서기능이우수하여기록용재료및 센서재료로응용될수 있다.

公开(公告)号：KR1020010038525A

公开(公告)日：2001-05-15

申请号：KR1019990046512

申请日：1999-10-26

Applicant: 한국과학기술연구원

Inventor： 안광덕 ,  김종만 ,  한동근 ,  강종희

IPC: C07C50/18

CPC classification number: Y02P20/55

Abstract: PURPOSE: A method for forming a fine fluorescent image by using protected hydroxy group-containing anthraquinone derivatives or naphthacenequinone derivatives is provided. Thereby the obtained protected hydroxy group-containing compound can be applied to recording material and censor material because it can easily form a fine fluorescent image of micrometer units under the condition of a chemically amplified fine image forming process. CONSTITUTION: This method comprises the steps of: preparing a transparent solution by dissolving protected hydroxy group-containing anthraquinone derivatives of formula 1 or naphthacenequinone derivatives of formula 2 and a soluble polymer in an organic solvent; forming a thin film by coating the solution on a substrate; prebaking the thin film coated substrate; and removing a hydroxy protecting group of the anthraquinone derivatives or naphthacenequinone derivatives by treating under the condition of a chemically amplified fine image forming process.

Abstract translation: 目的：提供通过使用保护的含羟基蒽醌衍生物或并四苯醌衍生物形成精细荧光图像的方法。 由此，可以在化学放大精细图像形成工序的条件下容易地形成微米单位的微细荧光图像，将得到的保护的含羟基化合物施加到记录材料和检查材料上。 构成：该方法包括以下步骤：通过将保护的含羟基的式1的蒽醌衍生物或式2的并四苯醌衍生物和可溶性聚合物溶解在有机溶剂中来制备透明溶液; 通过将溶液涂布在基材上形成薄膜; 预烘烤薄膜涂布基材; 并通过在化学放大的精细成像方法的条件下处理除去蒽醌衍生物或萘并醌衍生物的羟基保护基。

公开(公告)号：KR1020020004331A

公开(公告)日：2002-01-16

申请号：KR1020000038132

申请日：2000-07-05

Applicant: 한국과학기술연구원 ,  주식회사 덴키스트

Inventor： 한동근 ,  안광덕 ,  김종만 ,  정진희

IPC: A61K6/00

CPC classification number: C08F2/46 ,  A61K6/083 ,  C08F222/1006 ,  C08F2222/1046 ,  Y10S522/908 ,  C08F2222/1033 ,  C08F2222/1013 ,  C08L33/00

Abstract: PURPOSE: A photopolymerizable composite resin composition for dental restoration using a multifunctional prepolymer mixture as a base material is provided, which has increased biocompatibility as well as exhibiting better physical and mechanical properties as compared to conventional compositions based on only Bis-GMA itself. CONSTITUTION: This composite resin composition comprises 2 to 40% by weight of multifunctional prepolymer mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl)propane ("Bis-GMA") of formula 1 and tri-GMA of formula 2 in a ratio of 95:5 to 5:95, 1 to 20% by weight of a diluent, 40 to 95% by weight of an inorganic filler, a photoinitiation system, and other additives. The composition has almost no cytotoxicity and high strength and hardness.

Abstract translation: 目的：提供一种使用多官能预聚物混合物作为基础材料的用于牙科修复的可光聚合复合树脂组合物，与仅基于Bis-GMA本身的常规组合物相比，其具有增加的生物相容性以及表现出更好的物理和机械性能。 构成：该复合树脂组合物包含2至40重量％的式1的2,2-双 - （4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基）丙烷（“Bis-GMA”）的多官能预聚物混合物和 式2的三-GMA比例为95:5至5:95,1至20重量％的稀释剂，40至95重量％的无机填料，光引发体系和其它添加剂。 该组合物几乎没有细胞毒性和高强度和硬度。

公开(公告)号：KR1020010038527A

公开(公告)日：2001-05-15

申请号：KR1019990046514

申请日：1999-10-26

Applicant: 한국과학기술연구원

Inventor： 안광덕 ,  김종만 ,  박기홍 ,  한동근

IPC: C07D263/54

Abstract: PURPOSE: The pyridyl benzoxazole derivatives, their copolymers, and a fluorescence image making method are provided, thereby the pyridyl benzoxazole copolymers have good sensor properties in solution, film and particle status, so that they can be used as recording materials or sensor materials. CONSTITUTION: The pyridyl benzoxazole derivative is represented by formula (1), in which A and B are independently CH and N; R1 is alkyl or phenyl; R2 is O or NH, R3 is vinyl, acryl, allyl, alpha-methylvinyl or 4-vinylphenyl; m is an integer from 0 to 20. The pyridyl benzoxazole copolymer represented by formula (2) is produced by radical polymerization of comonomer selected from the group consisting of pyridyl benzoxazole derivatives, styrene, maleimide and methacrylate, in which A and B are independently CH and N; R1 is alkyl or phenyl; R2 is O or NH, m is an integer from 0 to 20; R4 is hydrogen or methyl; R5 is methyloxycarbonyl or phenyl; and x and y are integer from 10 to 5000. The fluorescence image making method comprises the steps of: dissolving pyridyl benzoxazole copolymer of formula (2) wherein A is CH and B is N, AIBN, organic acid or inorganic acid in an organic solvent; coating the solution on board and drying to form a thin layer; prebaking the thin layer; and exposing the thin layer to light using photomask and post-exposure baking it.

Abstract translation: 目的：提供吡啶基苯并恶唑衍生物，其共聚物和荧光图像制备方法，因此吡啶基苯并恶唑共聚物在溶液，膜和颗粒状态下具有良好的传感器性质，因此可用作记录材料或传感器材料。 构成：吡啶基苯并恶唑衍生物由式（1）表示，其中A和B独立地为CH和N; R1是烷基或苯基; R2是O或NH，R3是乙烯基，丙烯基，烯丙基，α-甲基乙烯基或4-乙烯基苯基; m是0至20的整数。由式（2）表示的吡啶基苯并恶唑共聚物是通过选自吡啶基苯并恶唑衍生物，苯乙烯，马来酰亚胺和甲基丙烯酸酯的共聚单体的自由基聚合制备的，其中A和B独立地为CH 和N; R1是烷基或苯基; R2是O或NH，m是0至20的整数; R4是氢或甲基; R5是甲氧基羰基或苯基; 荧光图像的制造方法包括以下步骤：将有机溶剂中A为CH且B为N的式（2）的吡啶基苯并恶唑共聚物，AIBN，有机酸或无机酸溶解 ; 将溶液涂布在板上并干燥以形成薄层; 预制薄层; 并使用光掩模将该薄层曝光并曝光后烘烤。