公开(公告)号：KR1020140012865A

公开(公告)日：2014-02-04

申请号：KR1020120080211

申请日：2012-07-23

Applicant: 안국바이오진단(주)

Inventor： 김종원

IPC: G01K7/22 ,  G01K7/24

CPC classification number: G01K7/24 ,  G01K15/005 ,  G01K2219/00

Abstract: A device for measuring temperature using a thermistor is disclosed. The device for measuring the temperature, which converts a voltage to a temperature, includes: a negative temperature coefficient (NTC) thermistor for variously outputting a voltage input based on temperature changes; a reference resistor connected to the NTC thermistor in series; and an analog-to-digital convertor which is individually connected to the NTC thermistor and to the reference resistor in parallel and which receives a voltage divided from the voltage input using the reference resistor from the NTC thermistor to produce digital output by converting the divided voltage to a temperature. [Reference numerals] (AA) NTC thermistor; (BB) Reference resistor

Abstract translation: 公开了一种使用热敏电阻测量温度的装置。 用于将电压转换为温度的温度测量装置包括：用于根据温度变化不同地输出电压输入的负温度系数（NTC）热敏电阻; 串联连接到NTC热敏电阻的参考电阻; 以及模数转换器，其并联地连接到NTC热敏电阻和参考电阻器，并且从NTC热敏电阻接收使用参考电阻器输入的电压分压的电压，以通过转换分压电压来产生数字输出 达到温度。 （标号）（AA）NTC热敏电阻; （BB）参考电阻

公开(公告)号：KR100693392B1

公开(公告)日：2007-03-12

申请号：KR1020000034576

申请日：2000-06-22

Applicant: 안국바이오진단(주)

Inventor： 조한상 ,  김미선 ,  윤걸중

IPC: A61M1/10

CPC classification number: A61M1/1051 ,  A61M1/1037 ,  A61M1/122

Abstract: 개시된 내용은 소형으로 모듈화시켜 급성 심부전증(心不全症)이 있는 환자의 체내에 이식함으로써 저하된 심장의 기능을 복구하도록 보조할 수 있는 실린더리칼 캠을 이용한 체내 이식형 좌심실 보조장치에 관한 것이다.
이를 위해, 심장병환자에게 장치되어 심장을 보조하는 장치에 있어서, 직진왕복구동력을 발생하는 액츄에이터; 상기 액츄에이터에 의해 직진왕복운동하는 가압판; 상기 가압판의 왕복운동으로 밀착 또는 해제되면서 수축/팽창하여 혈액을 압출하여 공급하는 혈액주머니; 및 상기 혈액주머니, 가압판 및, 액츄에이터를 수납하여 물리적으로 결합시켜서 체내에서 보호하는 챔버를 포함하여 구성되되, 상기 액츄에이터는 모터와, 모터축 기어가 구비되며 모터에 의해 회전되는 모터축과, 상기 모터축 기어와 치합되어 감속되면서 회전되는 유성기어체와, 상기 유성기어체의 중심부에 고정된 통형의 고정부와 상기 고정부에 비해 큰 원통형으로 이루어지며 내측에 한쌍의 롤러가 장착된 원통형부를 구비한 주축과, 일단이 가압판에 결합되면서 상기 원통형부 내에 삽입되고 상기 롤러가 수용되도록 외주면의 둘레를 따라 서로 교차되는 한 쌍의 캠홈이 형성되며 이 캠홈의 길이에 따라 왕복 이동 거리가 결정되는 실린더리칼 캠과 상기 유성기어체의 외측에 치합되는 링기어부가 구비되며 상기 모터 및 주축이 설치되며 실린더리칼 캠, 주축, 유성기어체, 모터축 및 모터를 수용하는 케이스와 후방덮개를 포함하는 것을 특징으로 하는 실린더리칼 캠을 이용한 체내 이식형 좌심실 보조장치를 제공한다.
심장, 좌심실, 심실보조장치, 심부전증

公开(公告)号：KR100464259B1

公开(公告)日：2005-01-03

申请号：KR1020020039464

申请日：2002-07-08

Applicant: 안국바이오진단(주) ,  재단법인한국간연구재단

Inventor： 김범준 ,  조문제 ,  국윤호 ,  김정미 ,  박정민

IPC: C12Q1/68

Abstract: PURPOSE: An identification method of Streptomyces having rifampin resistance or sensitivity using rpoB gene, and a primer specific to Streptomyces having rifampin resistance or sensitivity are provided, thereby simplifying the method, decreasing the costs therefor and improving the accuracy thereof. CONSTITUTION: An identification method of Streptomyces having rifampin resistance or sensitivity is characterized by using the nucleotide sequence difference encoding an amino acid of a rpoB gene of Streptomyces sp. corresponding to the 352th amino acid in RNA polymerase subunit B of Streptomyces coelicolor, wherein the nucleotide sequence encoding the amino acid is 258-bp to 260-bp of nucleotide sequence from the 5-terminal of a 352-bp fragment obtained by amplifying the rpoB gene of Streptomyces sp. using a pair of primers having the nucleotide sequences of SEQ ID NO: 1 and SEQ ID NO: 2.

Abstract translation: 目的：提供使用rpoB基因的具有利福平抗性或灵敏度的链霉菌的鉴定方法，以及对具有利福平耐受性或灵敏度的链霉菌特异性的引物，从而简化了方法，降低了成本并提高了其准确度。 构成：具有利福平抗性或敏感性的链霉菌的鉴定方法的特征在于使用编码链霉菌属的rpoB基因的氨基酸的核苷酸序列差异。 其对应于天蓝色链霉菌的RNA聚合酶亚基B中的第352位氨基酸，其中编码该氨基酸的核苷酸序列是从扩增rpoB获得的352-bp片段的5'端的核苷酸序列的258-bp至260-bp 链霉菌属的基因。 使用具有SEQ ID NO：1和SEQ ID NO：2的核苷酸序列的一对引物。

公开(公告)号：KR100460747B1

公开(公告)日：2004-12-08

申请号：KR1020020054330

申请日：2002-09-09

Applicant: 안국바이오진단(주)

Inventor： 김정미 ,  이지영 ,  윤성욱

IPC: C12Q1/68

Abstract: PURPOSE: A probe for detecting human herpesvirus(HHV), a genotyping kit and a genotyping method for human herpesvirus using the same are provided, thereby rapidly, simply and accurately detecting HHV which consists of Herpes Simplex virus type 1(HSV-1), HSV-2 and human herpesvirus-8(HHV-8) and causes STD(sexual transmitted disease). CONSTITUTION: A probe for detecting human herpesvirus(HHV) is selected from oligonucleotides having the nucleotide sequences of SEQ ID NO: 1 to SEQ ID NO: 9 and complementary oligonucleotides thereof and complementarily binds to the nucleic acid of human herpesvirus. A DNA chip for detecting human herpesvirus(HHV) or genotyping of HHV contains at least one probes selected from oligonucleotides having the nucleotide sequences of SEQ ID NO: 1 to SEQ ID NO: 9 and complementary oligonucleotides thereof. A genotyping kit for human herpesvirus comprises (a) the DNA chip for detecting human herpesvirus, (b) a PCR primer and (c) a marker means for detecting amplified DNA hybridized with the DNA chip. A genotyping method for human herpesvirus comprises the steps of: (a) amplifying a sample DNA using the PCR primer; (b) hybridizing the amplified DNA on the DNA chip containing one probe or two or more of probe sets; and (c) detecting the product hybridized with the probe.

Abstract translation: 目的：提供一种用于检测人类疱疹病毒（HHV）的探针，基因分型试剂盒和使用其的人类疱疹病毒基因分型方法，从而快速，简单且准确地检测由单纯疱疹病毒1型（HSV-1）， HSV-2和人类疱疹病毒-8（HHV-8）并导致STD（性传播疾病）。 构成：用于检测人疱疹病毒（HHV）的探针选自具有SEQ ID NO：1至SEQ ID NO：9的核苷酸序列的寡核苷酸及其互补寡核苷酸，并与人类疱疹病毒的核酸互补结合。 用于检测人疱疹病毒（HHV）或HHV基因分型的DNA芯片含有至少一种选自具有SEQ ID NO：1至SEQ ID NO：9的核苷酸序列的寡核苷酸及其互补寡核苷酸的探针。 （a）用于检测人类疱疹病毒的DNA芯片，（b）PCR引物和（c）用于检测与DNA芯片杂交的扩增DNA的标记手段。 用于人疱疹病毒的基因分型方法包括以下步骤：（a）使用PCR引物扩增样品DNA; （b）在含有一个探针或两个或多个探针组的DNA芯片上杂交扩增的DNA; 和（c）检测与探针杂交的产物。

公开(公告)号：KR1020030067871A

公开(公告)日：2003-08-19

申请号：KR1020020007374

申请日：2002-02-08

Applicant: 안국바이오진단(주)

Inventor： 송희경 ,  김정미 ,  조장은 ,  박신이 ,  윤성욱 ,  한상엽

IPC: C12Q1/68

Abstract: PURPOSE: A lineage specific DNA microarray and a method for monitoring cell differentiation using the sam are provided, thereby easily and simply monitoring cell differentiation. CONSTITUTION: A lineage specific DNA microarray for monitoring cell differentiation comprises a marker gene inducing the cell differentiation or a probe capable of detecting the tissue specifically expressed marker gene and a substrate fixing the probe, wherein the probe is cDNA or oligonucleotide having 10 to 1000 bases to the marker gene; the marker gene is one or more gene selected from undifferentiated marker gene, endoderm marker gene, mesoderm marker gene, ectoderm marker gene and tissue marker gene derived from the germinal layer; the undifferentiated marker gene is OCT-4(octamer binding protein-4) or alkaline phosphorase; and the substrate is selected from silicone wafer, glass, polycarbonate, membrane and polymer film.

Abstract translation: 目的：提供谱系特异性DNA微阵列和使用sam监测细胞分化的方法，从而容易且简单地监测细胞分化。 构成：用于监测细胞分化的谱系特异性DNA微阵列包括诱导细胞分化的标记基因或能够检测组织特异性标记基因的探针和固定探针的底物，其中所述探针是具有10至1000个碱基的cDNA或寡核苷酸 标记基因; 标记基因是选自未分化标记基因，内胚层标记基因，中胚层标记基因，外胚层标记基因和源自生发层的组织标记基因的一种或多种基因; 未分化标记基因是OCT-4（八聚体结合蛋白-4）或碱性磷酸酶; 基板选自硅胶片，玻璃，聚碳酸酯，膜和聚合物膜。

公开(公告)号：KR1020030025787A

公开(公告)日：2003-03-29

申请号：KR1020020030285

申请日：2002-05-30

Applicant: 안국바이오진단(주)

Inventor： 조용구 ,  김현정 ,  김정미

IPC: G01N33/53

Abstract: PURPOSE: A quantitative method of protein using surface plasmon resonance(SPR) is provided, thereby specified disease and down syndrome can be diagnosed. CONSTITUTION: The quantitative method of a down syndrome-mark protein comprises the steps of: (a) reacting a self assembled monolayer compound with a surface plasmon layer to prepare the self assemble monolayer; (b) fixing an antibody of a target protein to the self assembled monolayer; (c) reacting a sample containing the target protein with the fixed antibody; (d) irradiating light to the surface plasmon layer to measure a change of refraction value; and (e) conversing the amount of the target protein using the change of refraction value and standardized amount of the target protein, wherein the compound of the step (a) has a function group being capable of the self assembled monolayer and regions recognizing positive ion; the function group is thiol, and the positive ion recognizing region is a crown ring; the light is 800 to 850 nm of light from light emitting diode(LED) and is detected by using photodiode array; the protein is alpha-fetoprotein, human chorionic gonadotropin or unconjugated estriol; and the antibody is monoclonal antibody or polyclonal antibody.

Abstract translation: 目的：提供使用表面等离子体共振（SPR）的蛋白质的定量方法，从而可以诊断出疾病和衰退综合征。 构成：下调综合征标记蛋白的定量方法包括以下步骤：（a）使自组装单层化合物与表面等离子体层反应，制备自组装单层; （b）将靶蛋白的抗体固定在自组装单层上; （c）使含有靶蛋白的样品与固定抗体反应; （d）向表面等离子体膜照射光以测量折射值的变化; （e）使用目标蛋白质的折射值和标准化量的变化对目标蛋白质的量进行转化，其中步骤（a）的化合物具有能够自组装单层的功能基团和​​识别阳离子的区域 ; 功能组为硫醇，正离子识别区为冠环; 光是发光二极管（LED）的800至850nm的光，并通过使用光电二极管阵列进行检测; 蛋白质是甲胎蛋白，人绒毛膜促性腺激素或非共轭雌三醇; 抗体是单克隆抗体或多克隆抗体。

公开(公告)号：KR1020030015124A

公开(公告)日：2003-02-20

申请号：KR1020020036731

申请日：2002-06-28

Applicant: 안국바이오진단(주) ,  김범준 ,  국윤호

Inventor： 김범준 ,  김정미 ,  국윤호 ,  이근화 ,  천종식 ,  배경숙

IPC: C12Q1/68

Abstract: PURPOSE: A primer set specific to genus Streptomyces, rpoB gene fractions, and an identification method of genus Streptomyces by using the same are provided, thereby identifying the genus Streptomyces easily and cheaply. CONSTITUTION: The primer set specific to genus Streptomyces is selected from the group consisting of primers having the nucleotide sequences of SEQ ID NOs: 1 and 2, specifically amplifying RNA polymerase B(rpoB) subunit gene. The polynucleotide is selected from the nucleotide sequences of SEQ ID NOs: 3 to 164 and comprises 306 bp of the rpoB gene fraction of the genus Streptomyces. The identification method of genus Streptomyces comprises the steps of: (i) amplifying the rpoB gene fraction of a strain using the primer set specific to the genus Streptomyces; (ii) sequencing the amplified ropB gene fractions; and (iii) comparing the nucleotide sequences analyzed in the step (ii) and the rpoB gene sequence.

Abstract translation: 目的：提供特异性链霉菌属的引物组，rpoB基因级分，以及通过使用该引物对链霉菌属的鉴定方法，从而易于且便宜地鉴定链霉菌属。 构成：特异于链霉菌属的引物组选自具有SEQ ID NO：1和2的核苷酸序列的引物组，特异性扩增RNA聚合酶B（rpoB）亚基基因。 多核苷酸选自SEQ ID NO：3至164的核苷酸序列，并且包含306bp的链霉菌属的rpoB基因级分。 链霉菌属的鉴定方法包括以下步骤：（i）使用特异于链霉菌属的引物组扩增菌株的rpoB基因级分; （ii）测序扩增的ropB基因级分; 和（iii）比较步骤（ii）中分析的核苷酸序列和rpoB基因序列。

公开(公告)号：KR1020020001953A

公开(公告)日：2002-01-09

申请号：KR1020000034576

申请日：2000-06-22

Applicant: 안국바이오진단(주)

Inventor： 조한상 ,  김미선 ,  윤걸중

IPC: A61M1/10

CPC classification number: A61M1/1051 ,  A61M1/1037 ,  A61M1/122

Abstract: PURPOSE: An implantation assist device for left ventricle of heart is provided to be safely and simply implanted in the body so as to increase blood flow of the main artery, thereby recovering declined function of the heart. CONSTITUTION: An implantation assist device for left ventricle of a heart comprises an actuator(100) for generating driving force for flowing blood, a press plate(200) for transferring the driving force, a blood bag for discharging or introducing blood. The blood bag corresponds to a ventricle of the heart. The actuator, press plate and blood bag are received in a chamber(400) consisting of a forward chamber in which the blood bag and press plate are received and a rear chamber in which the actuator is received. The press plate has a flat disc type press face(210) corresponding to the blood bag, and an engaging hole on its center portion with which a movable part of the actuator is engaged.

Abstract translation: 目的：提供心脏左心室植入辅助装置，安全简便地植入体内，以增加主动脉的血流量，从而恢复心脏功能下降。 构成：用于心脏左心室的植入辅助装置包括用于产生用于流动血液的驱动力的致动器（100），用于传递驱动力的压板（200），用于排出或引入血液的血袋。 血袋对应于心脏的心室。 致动器，压板和血袋被容纳在由容纳血袋和压板的前方室和容纳致动器的后室组成的室（400）中。 压板具有对应于血袋的平盘型按压面（210），以及在其中心部分上与致动器的可动部分接合的接合孔。

公开(公告)号：KR100312712B1

公开(公告)日：2001-11-03

申请号：KR1019990001577

申请日：1999-01-20

Applicant: 안국바이오진단(주) ,  민병구

Inventor： 김현정

IPC: A61L33/00

Abstract: 개시된내용은폴리아크릴산과 4-아지도아닐린하이드로클로라이드를반응시켜광반응성폴리아크릴산(PPA-Ⅱ)을합성하는제 1단계; 상기 PPA-Ⅱ를광반응에의해생체재료표면에도포하는제 2단계; 및상기 PPA-Ⅱ가고정된생체재료표면에대해룸부로키나제를 EDC반응으로고정시키는제 3단계를포함하는룸부로키나제의생체재료표면고정화방법에관한것이다. 본발명의구성에의해, 룸부로키나제를생체재료표면에고정할때, 룸부로키나제의활성을변화시키지않고, 또한특정부위에만고정할수 있는효과가있다.

公开(公告)号：KR1020010091450A

公开(公告)日：2001-10-23

申请号：KR1020000013161

申请日：2000-03-15

Applicant: 안국바이오진단(주)

Inventor： 김성근 ,  김진희 ,  박태신 ,  박미선

IPC: C12Q1/68

CPC classification number: C12Q1/708 ,  C12Q1/6886

Abstract: PURPOSE: Provided is a diagnosis kit article for the genotype of human papillomavirus(HPV) which is a main cause of cervical dysplasia. And its manufacturing method is also provided. CONSTITUTION: The kit article consists of an oligonucleotide microarray manufactured by fixing HPV type specific oligonucleotide probes onto a glass, silylated slide, by Schiff base reaction, and streptavidine-R-phycoerythrin containing biotin-binding proteins to detect the hybridization reaction of biotin labeled DNA ampliers and the probe oligomers fixed on the glass. Its manufacturing method comprises the steps of: modifying HPV type specific DNA probes with an amine group; inducing an aldehyde group on a glass; fixing the modified DNA probes to the glass by Schiff base reaction.

Abstract translation: 目的：提供人乳头状瘤病毒（HPV）基因型的诊断试剂盒文章，这是宫颈发育不良的主要原因。 并提供其制造方法。 构成：试剂盒文章由通过将HPV型特异性寡核苷酸探针固定在玻璃，甲硅烷基化载玻片上，通过席夫碱反应制造的寡核苷酸微阵列和含有生物素结合蛋白的链霉亲和素-R-藻红蛋白来检测生物素标记的DNA的杂交反应 放大器和固定在玻璃上的探针低聚物。 其制备方法包括：用胺基改性HPV型特异性DNA探针; 在玻璃上诱导醛基; 通过席夫碱反应将修饰的DNA探针固定在玻璃上。