公开(公告)号：KR101157526B1

公开(公告)日：2012-06-22

申请号：KR1020110094918

申请日：2011-09-20

Applicant: 한국과학기술원 ,  서울대학교산학협력단

Inventor： 강창원 ,  김은준 ,  김재원 ,  김은진 ,  원혜정 ,  마원 ,  조수철

IPC: C12Q1/68 ,  C12N15/12

CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  G01N21/76 ,  C12Q1/6844

Abstract: PURPOSE: A composition for diagnosing risk of developing ADHD and a kit are provided to classify a risk group of developing ADHD and to prevent ADHA. CONSTITUTION: A composition for diagnosing ADHA contains a polynucleotide of rs550818 SNP in GIT gene having24926101th C/T base of 17th human chromosome. The composition contains likage disequilibrium site near the rs550818 SNP. A method for predicting risk of developing ADHD comprises: a step of isolating DNAs from a biological sample of a subject; a step of identifying the rs550818 SNP base at 24926101th base site in 17th human chromosome; and a step of determining high risk of developing ADHD in case that the rs550818 SNP allele is C/T.

Abstract translation: 目的：提供一种用于诊断发展中ADHD风险的组合物和一个试剂盒，用于分类发展中的ADHD的风险组并防止ADHA。 构成：用于诊断ADHA的组合物含有GIT基因中rs550818 SNP的多核苷酸，其具有第17个人染色体的第24926101个C / T碱基。 该组合物包含rs550818 SNP附近的可能不平衡位点。 用于预测发展中的ADHD的风险的方法包括：从受试者的生物样品中分离DNA的步骤; 在第17个人类染色体的第24926101个碱基位点鉴定rs550818 SNP碱基的步骤; 并且在rs550818 SNP等位基因为C / T的情况下确定发生ADHD的高风险的步骤。

公开(公告)号：KR101127756B1

公开(公告)日：2012-03-23

申请号：KR1020110089182

申请日：2011-09-02

Applicant: 한국과학기술원

Inventor： 김은준 ,  강창원 ,  마원 ,  원혜정 ,  함은경 ,  김은진

IPC: A01K67/027 ,  C12N15/01 ,  G01N33/15

CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356

Abstract: PURPOSE: A GIT1 gene deficient mouse and a drug screening method using the same are provided to analyze the reason of the attention-deficit hyperactivity disorder and to decipher various kinds of anxiety disorders and diseases. CONSTITUTION: A drug screening method using a GIT1 gene deficient mouse is as follows. A therapeutic agent candidate material of attention-deficit hyperactivity disorder(ADHD) of mammal except for the human is dosed. After the candidate material is administered, an attention-deficit hyperactivity disorder test of mammal except for the human is performed. The candidate material causing the reduction of the attention deficiency hyperactivity disorder is selected.

Abstract translation: 目的：提供GIT1基因缺陷小鼠及其使用药物筛选方法，分析注意力缺陷多动障碍的原因，解读各种焦虑症和疾病。 构成：使用GIT1基因缺陷小鼠的药物筛选方法如下。 给予哺乳动物除人之外的注意缺陷多动障碍（ADHD）的治疗剂候选物质。 在施用候选物质之后，进行除人之外的哺乳动物的注意缺陷多动障碍试验。 选择引起注意缺陷多动障碍减轻的候选物质。