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Patent Agency Ranking
公开(公告)号：KR100979462B1
公开(公告)日：2010-09-02
申请号：KR1020070077934
申请日：2007-08-03
Applicant: 한국화학연구원
Abstract: 본 발명은 안트라사이클라인계 항암약물 봉입용 리포솜 및 이의 제조방법에 관한 것으로, 더욱 상세하게는 양전하를 갖는 지질과 인지질을 함유하는 리포솜에 폴리에틸렌글리콜(PEG) 유도체를 도입하여 이온성 리포솜을 제조함으로써 암세포 내로 효과적으로 이입되어 항암약물의 투여가 용이한 세포이입성이 증진된 안트라사이클라인계 항암약물 봉입용 리포솜 및 이의 제조방법에 관한 것이다.
안트라사이클라인계 항암약물, 리포솜, 폴리에틸렌글리콜 유도체, 세포이입성-
公开(公告)号：KR1020090013848A
公开(公告)日：2009-02-06
申请号：KR1020070077934
申请日：2007-08-03
Applicant: 한국화학연구원
CPC classification number: A61K9/1273 , A61K47/34
Abstract: A liposome for encapsulating anthracycline anticancer drug is provided to improve absorption efficiency of liposome delivered to the tumor tissue into the cancer cell by introducing PEG(polyethylene glycol) to the phospholipid having positive charge or the surface of liposome containing this. The ionic liposome for encapsulating anthracycline anticancer drug is prepared by introducing PEG derivative into the phospholipid having positive charge which is 1,2-disteroyl-3-trimethylammonium-propane(DOTAP), dimethyldioctadecylammonium(DDAB), 1,2-diacyl-3-dimethyl ammonium propane(DAP) or L-a-dioleylphosphatidylethanolamine(DOPE), or the surface of liposome containing this.
Abstract translation: 提供用于包封蒽环类抗癌药物的脂质体，以通过将PEG（聚乙二醇）引入具有正电荷的磷脂或含有这种脂质体的表面来提高向肿瘤组织递送至肿瘤组织的脂质体的吸收效率。 通过将PEG衍生物引入具有1,2-二甲酰基-3-三甲基铵 - 丙烷（DOTAP），二甲基二十八烷基铵（DDAB），1,2-二酰基-3-甲基丙烷的正电荷的磷脂中制备用于封装蒽环类抗癌药物的离子脂质体， 二甲基铵丙烷（DAP）或者La-二油基磷脂酰乙醇胺（DOPE），或含有此的脂质体的表面。
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公开(公告)号：KR1020090021065A
公开(公告)日：2009-02-27
申请号：KR1020080019750
申请日：2008-03-03
Applicant: 한국화학연구원
CPC classification number: A61K47/42 , A61K9/1271 , A61K9/1277 , A61K31/663 , A61K38/12
Abstract: A liposome coated with protein is provided to improve the in vivo circulation time in bloodstream compared to the conventional liposome, strengthen the stability in plasma, and inhibit adsorption to plasma protein, thereby enhancing drug delivery efficiency to the target area in the body and continuance of medicine effect exhibition. The liposome coated with protein having increased in vivo circulation time in bloodstream is prepared by binding the protein to the surface of liposome including cationic lipid through ionic bond, wherein the protein is selected from albumin, globulin, glutenin, prolamine, albuminoid, nucleoprotein, glycoprotein, phosphoprotein, lipoprotein, chromoprotein, gelatin, proteose, peptone, dipeptide and tripeptide, and has the average molecular weight of 2,000-1,500,000 Da.
Abstract translation: 提供涂覆有蛋白质的脂质体，以改善血液中体内循环时间，与常规脂质体相比，增强血浆中的稳定性，抑制血浆蛋白的吸附，从而提高药物对体内目标区域的输送效率，并持续 药效展览。 通过将蛋白质与包括通过离子键结合的阳离子脂质的脂质体表面结合来制备涂有血液中体内循环时间增加的蛋白质的脂质体，其中蛋白质选自白蛋白，球蛋白，谷蛋白，谷醇溶蛋白，类白蛋白，核蛋白，糖蛋白 ，磷蛋白，脂蛋白，生色蛋白，明胶，蛋白质，蛋白胨，二肽和三肽，平均分子量为2,000-1,500,000 Da。
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公开(公告)号：KR1020080101056A
公开(公告)日：2008-11-21
申请号：KR1020070047259
申请日：2007-05-15
Applicant: 한국화학연구원
IPC: A61K9/10 , A61K31/337 , B82B1/00 , B82Y5/00
CPC classification number: A61K9/127 , A61K31/685 , A61K31/688 , A61K47/44 , A61K9/107 , A61K31/337 , A61K2300/00 , B82B1/00 , B82Y5/00
Abstract: A diterpenoid alkaloid group drug solution is provided to become soluble in a water phase at a high concentration without a surfactant harmfulness to human body by including a lipid nano particle, to have a size distribution of a uniform particle and to be used as an injection having a high safety. A diterpenoid alkaloid group drug solution is manufactured by dispersing diterpenoid alkaloid group drug having a solid solution state and lipid nano particles in an aquatic medium. The lipid nano particles are manufactured by dispersing a lipid mixture comprising phospholipid, sterols, cationic lipid or anionic lipid and polyethylene glycol in an organic solvent. A mixing ratio of the phospholipid, the sterols, the cationic lipid or the anionic lipid and the polyethylene glycol is 3 ~ 8 : 2 ~ 6 : 1 ~ 5 : 0 ~ 3.
Abstract translation: 提供二萜类生物碱类药物溶液，通过包含脂质纳米颗粒，高浓度而不会对人体具有表面活性物质的危害而在水相中溶解，具有均匀粒子的粒度分布，并用作具有 安全性高。 通过将具有固溶态的二萜生物碱类药物和脂质纳米颗粒分散在水性介质中制备二萜类生物碱类药物溶液。 通过将包含磷脂，固醇，阳离子脂质或阴离子脂质和聚乙二醇的脂质混合物分散在有机溶剂中来制备脂质纳米颗粒。 磷脂，固醇，阳离子脂质或阴离子脂质和聚乙二醇的混合比为3〜8：2〜6：1〜5：0〜3。
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公开(公告)号：KR100996975B1
公开(公告)日：2010-11-29
申请号：KR1020080019750
申请日：2008-03-03
Applicant: 한국화학연구원
Abstract: 본 발명은 혈류 내 순환시간을 증가시킨 단백질로 수식된 리포솜 및 이의 제조방법에 관한 것으로서, 더욱 상세하게는 생체적합성 단백질을 양이온성 리포솜 표면에 정전기적 상호인력으로 이온 결합시키고, 리포솜 표면에 결합된 단백질을 변성시켜 리포솜과의 결합력이 강화시킴으로써 리포솜이 혈류 내에서 순환할 때 혈장 내 단백질의 흡착을 방지하여 혈류 내에서 리포솜의 안정성을 강화하는 한편, 체내 순환시간을 증가시키는 리포솜 및 이의 제조방법에 관한 것이다.
단백질, 수식, 리포솜, 이온 결합, 체내 순환시간
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