公开(公告)号：KR1020020040160A

公开(公告)日：2002-05-30

申请号：KR1020000070105

申请日：2000-11-23

Applicant: 한국화학연구원

Inventor： 박노상 ,  정영식 ,  성철민 ,  임희종 ,  조보영 ,  공재양

IPC: C07C50/26

Abstract: PURPOSE: Provided is a quinone compound having excellent antioxidant activity, which can be used for preventing aging and curing cancer, diabetes, epilepsy, imbecility, Parkinson's disease, and etc. CONSTITUTION: The quinone compound is represented by the formula 1 and produced from a compound represented by the formula 3, wherein R1 and R2 are independently methyl or methoxy or R1 and R2 are connectively -CH=CH-CH=CH-, R3 is -NH-(CH2)m-R5, -CO2R6, -OH, and etc., R5 is methyl, phenyl, benzyl, and etc., R6 is hydrogen atom or C1-C4 alkyl, X is CH2 or C=O, and n and m are each 0 or an integer of 1-10.

Abstract translation: 目的：提供具有优异抗氧化活性的醌化合物，其可用于预防老化和治愈癌症，糖尿病，癫痫，不育，帕金森病等。构成：醌化合物由式1表示并由 由式3表示的化合物，其中R 1和R 2独立地是甲基或甲氧基或R 1和R 2连接地是-CH = CH-CH = CH-，R 3是-NH-（CH 2）m -R 5，-CO 2 R 6，-OH， R 5是甲基，苯基，苄基等，R 6是氢原子或C 1 -C 4烷基，X是CH 2或C = O，n和m各自为0或1-10的整数。

公开(公告)号：KR100472086B1

公开(公告)日：2005-02-21

申请号：KR1020010073307

申请日：2001-11-23

Applicant: 한국화학연구원

Inventor： 박노상 ,  정영식 ,  성철민 ,  임희종 ,  조보영 ,  공재양 ,  박우규

IPC: C07D241/04

Abstract: 본 발명은 우수한 항산화 활성을 갖는 3,5-디알콕시-4-히드록시페닐기로 치환된 피페라진 유도체, 그의 제조방법 및 이를 포함하는 약학적 조성물에 관한 것으로, 더욱 구체적으로 하기 화학식 1로 표시되는 3,5-디알콕시-4-히드록시페닐기로 치환된 피페라진 유도체는 종래 항산화제 화합물에 비해 항산화 활성이 우수할 뿐만 아니라 독성이 낮아 노화 방지제, 암, 당뇨병 및 간질의 치료제, 그리고 치매, 파킨스씨 병, 뇌졸중 및 헌팅톤의 신경퇴행성 질환치료제로 유용하게 사용될 수 있다.
화학식 1

(상기 식에서, R, X 및 Y는 명세서 내에 기재된 바와 같다.)

公开(公告)号：KR100398055B1

公开(公告)日：2003-09-19

申请号：KR1020000070105

申请日：2000-11-23

Applicant: 한국화학연구원

Inventor： 박노상 ,  정영식 ,  성철민 ,  임희종 ,  조보영 ,  공재양

IPC: C07C50/26

Abstract: PURPOSE: Provided is a quinone compound having excellent antioxidant activity, which can be used for preventing aging and curing cancer, diabetes, epilepsy, imbecility, Parkinson's disease, and etc. CONSTITUTION: The quinone compound is represented by the formula 1 and produced from a compound represented by the formula 3, wherein R1 and R2 are independently methyl or methoxy or R1 and R2 are connectively -CH=CH-CH=CH-, R3 is -NH-(CH2)m-R5, -CO2R6, -OH, and etc., R5 is methyl, phenyl, benzyl, and etc., R6 is hydrogen atom or C1-C4 alkyl, X is CH2 or C=O, and n and m are each 0 or an integer of 1-10.

Abstract translation: 目的：提供一种具有优异的抗氧化活性的醌化合物，其可用于预防衰老和治疗癌症，糖尿病，癫痫，肌无力，帕金森氏症等。组成：醌化合物由式1表示，由 由式3表示的化合物，其中R 1和R 2独立地为甲基或甲氧基或者R 1和R 2连接地为-CH = CH-CH = CH-，R 3为-NH-（CH 2）m -R 5，-CO 2 R 6，-OH， R5是甲基，苯基，苄基等，R6是氢原子或C1-C4烷基，X是CH2或C = O，n和m各自是0或1-10的整数。

公开(公告)号：KR1020030042591A

公开(公告)日：2003-06-02

申请号：KR1020010073307

申请日：2001-11-23

Applicant: 한국화학연구원

Inventor： 박노상 ,  정영식 ,  성철민 ,  임희종 ,  조보영 ,  공재양 ,  박우규

IPC: C07D241/04

Abstract: PURPOSE: A method of preparing a piperazine derivative substituted by 3,5-dialkoxy-4-hydroxyphenyl group is provided. The piperazine derivative have antioxidant and anticancer activities as well as is used for treatment of diabetes, epilepsy, stroke, Parkinson's disease, and other neurodegenerative disorders. CONSTITUTION: A piperazine derivative(formula 1) substituted by 3,5-dialkoxy-4-hydroxyphenyl group, and pharmaceutically acceptable salts thereof have improved anti-oxidation activity, compared to the usual antioxidant compounds. In the formula(1), R is hydrogen, or alkyl group containing saturated or unsaturated carbon of C1-C15, X is alkyl group of C1-C3, -CH=CHC(O)- or -CH2CH2C(O)-, and Y is hydrogen, halogen, hydroxy group, amino group, alkyl group of C1-C5, alkoxy group of C1-C5, or phenyl group.

Abstract translation: 目的：提供由3,5-二烷氧基-4-羟基苯基取代的哌嗪衍生物的制备方法。 哌嗪衍生物具有抗氧化和抗癌活性，并用于治疗糖尿病，癫痫，中风，帕金森病和其他神经变性疾病。 构成：与通常的抗氧化剂化合物相比，由3,5-二烷氧基-4-羟基苯基取代的哌嗪衍生物（式1）及其药学上可接受的盐具有改善的抗氧化活性。 在式（1）中，R为氢或C1-C15的饱和或不饱和碳的烷基，X为C1-C3，-CH = CHC（O） - 或-CH2CH2C（O） - 的烷基， Y为氢，卤素，羟基，氨基，C1-C5烷基，C1-C5烷氧基或苯基。