公开(公告)号：KR100634381B1

公开(公告)日：2006-10-16

申请号：KR1020050112495

申请日：2005-11-23

Applicant: 한국화학연구원

Inventor： 조선행 ,  이해방 ,  강길선 ,  임낙현 ,  이하영 ,  지혜원 ,  서진아 ,  서성미 ,  이현숙

IPC: C08G73/10 ,  C08F8/32 ,  B82Y5/00

Abstract: Provided are a polysuccinimide-based polymer which shows excellent polymer particle size control, biodegradability and contrast effect when nanoparticles are formed, and a contrast agent containing the polymer. The polysuccinimide-based polymer comprises a main chain having a molecular weight of 1,000-100,000; and a side chain which comprises a hydrophilic group having a molecular weight of 100-20,000 derived from D-lysine, L-lysine, D,L-lysine, polylysine, polyethylene glycol, poly(vinyl pyrrolidone), dextran, polyethylene oxide or poly(vinyl alcohol), a hydrophobic group derived from a C3-C80 amine or phospholipid, and a chelating group where a contrast agent selected from gadolinium, manganese, iron oxide, aluminum, silicon, barium, yttrium and rare earth elements is trapped.

Abstract translation: 本发明提供一种聚琥珀酰亚胺系聚合物和含有该聚合物的造影剂，其显示出优异的聚合物粒径控制，生物降解性和造影效果。 基于聚琥珀酰亚胺的聚合物包含分子量为1,000-100,000的主链; 和包含衍生自D-赖氨酸，L-赖氨酸，D，L-赖氨酸，聚赖氨酸，聚乙二醇，聚（乙烯基吡咯烷酮），葡聚糖，聚环氧乙烷或聚（乙烯吡咯烷酮）的分子量为100-20,000的亲水基团的侧链 （乙烯醇），衍生自C3-C80胺或磷脂的疏水性基团和选自钆，锰，氧化铁，铝，硅，钡，钇和稀土元素的造影剂被捕获的螯合基团。

公开(公告)号：KR100635026B1

公开(公告)日：2006-10-16

申请号：KR1020050112496

申请日：2005-11-23

Applicant: 한국화학연구원

Inventor： 조선행 ,  이해방 ,  강길선 ,  임낙현 ,  이하영 ,  지혜원 ,  서진아 ,  서성미 ,  이현숙

IPC: C08G73/06 ,  C08G73/10 ,  C08G61/12 ,  B82Y5/00

Abstract: Provided are a polysuccinimide-based polymer which is excellent in the size control of polymer particles, biodegradability and contrast effect, and a contrast agent containing the polysuccinimide-based polymer. The polysuccinimide-based polymer is represented by the formula 1, wherein R1 is a hydrophilic group having a molecular weight of 100-20,000 derived from D-lysine, L-lysine, D,L-lysine, polylysine, polyethylene glycol, poly(vinyl pyrrolidone), dextran, polyethylene oxide or poly(vinyl alcohol); and R2 is a chelating group where a contrast agent selected from gadolinium, manganese, iron oxide, aluminum, silicon, barium, yttrium and rare earth elements is trapped.

Abstract translation: 本发明提供聚合物粒子的尺寸控制，生物降解性和对比度效果优异的聚琥珀酰亚胺系聚合物和含有聚琥珀酰亚胺系聚合物的造影剂。 聚琥珀酰亚胺基聚合物由式1表示，其中R 1是衍生自D-赖氨酸，L-赖氨酸，D，L-赖氨酸，聚赖氨酸，聚乙二醇，聚（乙烯基乙烯基醚）的分子量为100-20,000的亲水基团 吡咯烷酮），葡聚糖，聚环氧乙烷或聚（乙烯醇）; R2是选自钆，锰，氧化铁，铝，硅，钡，钇和稀土元素的造影剂被捕获的螯合基团。