中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

15 records (took 0.018 seconds)

    4-아미노페닐아세트아미드 유도체와 그의 제조방법
    2.
    发明授权
    4-아미노페닐아세트아미드 유도체와 그의 제조방법 失效
    4-氨基苯基乙酰胺衍生物及其制备方法

    公开(公告)号：KR1019960016467B1

    公开(公告)日：1996-12-12

    申请号：KR1019930005828

    申请日：1993-04-07

    Applicant: 한국화학연구원

    Inventor： 박노상 ,  하덕찬 ,  최중권 ,  김현숙 ,  이광숙

    IPC: C07C235/18

    Abstract: The 4-aminophenylaceteamide derivatives or pharmaceutically acceptable salts thereof are shown by the following structure formula(I). In this formula, X is hydrogen, halogen, hydroxy or methoxy, R is (CH2)nR1, where n is 1 to 19, R1 is methyl or benzene ring unsubstituted or substituted with halogen, methylenedioxy, trifluoromethyl, alkyl or alkoxy. Y is amino unsubstituted or substituted with acyl, alkyl, aminoalkyl, aminocarbonyl or amino thiocarbonyl and a ring can be formed, when alkyl or aminoalkyl is substituted. The compound of the following general formula(I) is prepared by the steps of: (i)reacting a 4-aminophenyl acetic acid of the following structure formula(II-a) and an amine compound of the following general formula(III) to obtain a compound of the following structure formula(IV), and then (ii)introducing an amino substituent into the structure formula(IV).

    Abstract translation: 4-氨基苯基乙酰胺衍生物或其药学上可接受的盐由以下结构式（I）表示。 在该式中，X为氢，卤素，羟基或甲氧基，R为（CH2）nR1，其中n为1至19，R1为未取代的或被卤素，亚甲二氧基，三氟甲基，烷基或烷氧基取代的甲基或苯环。 当烷基或氨基烷基被取代时，Y是未取代的或被酰基，烷基，氨基烷基，氨基羰基或氨基硫代羰基取代的氨基，并且可以形成环。 通过以下步骤制备下列通式（I）的化合物：（i）使下列结构式（II-a）的4-氨基苯基乙酸与下列通式（III）的胺化合物反应于 得到以下结构式（IV）的化合物，然后（ii）将氨基取代基引入结构式（IV）中。

    N-아릴알킬 파라아미노에톡시페닐아세트아미드 유도체와 그의 제조방법
    3.
    发明授权
    N-아릴알킬 파라아미노에톡시페닐아세트아미드 유도체와 그의 제조방법 失效
    新型苯乙酰胺衍生物及其制备方法

    公开(公告)号：KR1019940011149B1

    公开(公告)日：1994-11-24

    申请号：KR1019910019641

    申请日：1991-11-06

    Applicant: 한국화학연구원

    Inventor： 박노상 ,  하덕찬 ,  최중권 ,  김현숙 ,  홍미숙 ,  이광숙

    IPC: C07C235/20

    Abstract: The N-arylalkyl para-aminoethoxyphenyl acetamide deriv. of formula (I) and its pharmaceuticall acceptable salt is prepd. by (a) reacting a cpd. of formula (II) with a sodium azide (NaN3) to obtain a cpd. of formula (III), and (b) reducing the cpd. (III) in the presence of a carbonaceous palladium catalyst, or reacting the cpd. (III) with a triphenyl phosphine in a tetrahydrofuran solvent in the presence of water. In the formulas, X is nitro, hydroxy or amino; Y is hydrogen, halogen, hydroxy, methylene dioxy or trifluoromethyl; Z is nitro or benzyloxy; n is 2-5; p is 0-5. The cpd. (I) has good analgesic and antiinflammatory activities.

    Abstract translation: N-芳基烷基对氨基乙氧基苯基乙酰胺衍生物。 的式（I）化合物及其药物可接受的盐是制备的。 通过（a）反应一个cpd。 （II）与叠氮化钠（NaN 3）反应，得到cpd。 的式（III），和（b）降低cpd。 （III）在碳质钯催化剂存在下反应，或使cpd反应。 （III）与三苯基膦在四氢呋喃溶剂中在水的存在下反应。 在该式中，X是硝基，羟基或氨基; Y是氢，卤素，羟基，亚甲基二氧基或三氟甲基; Z是硝基或苄氧基; n为2-5; p为0-5。 cpd。 （I）具有良好的止痛和抗炎活性。

    페닐아세트아미드 유도체 및 그의 제조방법
    9.
    发明授权
    페닐아세트아미드 유도체 및 그의 제조방법 失效
    苯乙酸衍生物及其制备方法

    公开(公告)号：KR1019920009574B1

    公开(公告)日：1992-10-19

    申请号：KR1019900001274

    申请日：1990-02-02

    Applicant: 한국화학연구원

    Inventor： 박노상 ,  하덕찬 ,  최중권 ,  김현숙 ,  임희종 ,  이광숙

    IPC: C07C233/08 ,  C07C235/18

    Abstract: Phenylacetamide derivs. of formula (I) and their acid addn. salts are new. In (I), R=C1-8 alkyl or cyclid alkyl; X= halogen, nitro, R1, OR1, SR1, or NR1R2; R1 and R2 each =H, C1-8 alkyl, cyclic alkyl or substd. phenyl; l = 0-5; m = 0-5; n = 1-6. Also claimed is the prepn. of (I) which comprises condensing a cpd. of formula (II) with phenylacetic acid of formula (III). The cpds. (I) may be used as an anti-inflammatory analgesic.

    Abstract translation: 苯乙酰胺衍生物。 的式（I）和它们的酸加成。 盐是新的。 在（I）中，R = C 1-8烷基或环烷基; X =卤素，硝基，R 1，OR 1，SR 1或NR 1 R 2; R1和R2各自为H，C1-8烷基，环烷基或取代基。 苯基; l = 0-5; m = 0-5; n = 1-6。 还声称是prepn。 （I），其包括冷凝cpd。 式（II）与式（III）的苯乙酸反应。 cpds。 （I）可以用作消炎止痛剂。

Patent Agency Ranking