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    작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물
    2.
    发明公开
    작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물 有权
    包含提取物的活性成分的药物组合物，其分离物或其分离的化合物作为活性成分

    公开(公告)号：KR1020120016861A

    公开(公告)日：2012-02-27

    申请号：KR1020100079356

    申请日：2010-08-17

    Applicant: 한국화학연구원

    Inventor： 김영섭 ,  유시용 ,  홍경식 ,  최춘환 ,  차미란 ,  박우규

    IPC: A61K36/65 ,  A61K31/343 ,  A61P25/28 ,  A61P25/00

    CPC classification number: A61K36/65 ,  A23L29/035 ,  A23V2200/322 ,  A61K31/216 ,  A61K31/343 ,  A61K2236/33

    Abstract: PURPOSE: A pharmaceutical composition containing Paeonia lactiflora seed extract, fraction thereof, or compound isolated from the same is provided to suppress BACE-1 activity and to treat and prevent neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neurodegenerative diseases contains Paeonia lactiflora seed extract as an active ingredient. The neurodegenerative diseases include Alzheimer's dieses, Parkinsons's disease, progressive supranuclear palsy. The extract is prepared using water, alcohol of C1-C4, or mixture solvent thereof. The pharmaceutical composition contains Paeonia lactiflora seed fraction as an active ingredient. The pharmaceutical composition also contains compounds as an active ingredient. The method for preparing the compounds comprises: a step of adding water, C1-C3 alcohol, or mixture thereof to the Paeonia lactiflora seeds to prepare Paeonia lactiflora seed extract; a step of fractioning the extract with water, dichloromethane, and ethyl acetate to prepare a fraction; a step of performing silicagel column chromatography of the fraction.

    Abstract translation: 目的：提供含有芍药提取物，其部分或从其分离的化合物的药物组合物以抑制BACE-1活性并治疗和预防神经变性疾病。 构成：用于预防或治疗神经变性疾病的药物组合物含有芍药种子提取物作为活性成分。 神经变性疾病包括阿尔茨海默氏病，帕金森氏病，进行性核上性麻痹。 萃取液用水，C1-C4的醇或其混合溶剂制备。 该药物组合物含有作为活性成分的芍药芍药种子。 药物组合物还含有作为活性成分的化合物。 制备化合物的方法包括：将水，C1-C3醇或其混合物加入到芍药种子中以制备芍药提取物的步骤; 用水，二氯甲烷和乙酸乙酯分级提取物以制备级分的步骤; 进行该级分的硅胶柱色谱的步骤。

    플럼바긴을 유효성분으로 함유하는 가시박 방제용 조성물
    3.
    发明公开
    플럼바긴을 유효성분으로 함유하는 가시박 방제용 조성물 失效
    对包含从PLUMBAGO AURICULATA衍生的PLUMBAGIN的SCIYOS ANGULATUS L.的除草剂组合物

    公开(公告)号：KR1020130049125A

    公开(公告)日：2013-05-13

    申请号：KR1020110114193

    申请日：2011-11-03

    Applicant: 한국화학연구원 ,  주식회사동방아그로

    Inventor： 최정섭 ,  고영관 ,  유시용 ,  최춘환 ,  차미란 ,  황인택 ,  한병수 ,  강광식 ,  엄준원

    IPC: A01N65/00 ,  A01N65/12 ,  A01P13/00

    CPC classification number: A01N65/08 ,  A01N25/02 ,  A01N25/06 ,  A01N25/26 ,  A01N35/06

    Abstract: PURPOSE: A composition containing Plumbagin as an active ingredient for preventing Sicyos angulatus is provided to suppress KAPAS(7-keto-8-aminopelargonic acid synthase) which is important for plant growth. CONSTITUTION: A herbicidal composition for preventing Sicyos angulatus contains Plumbagin as an active ingredient. Plumbagin is derived from Plumbago auriculata and is denoted by chemical formula 1. Plumbagin suppresses KAPAS activity by being treated in a concentration of 500-2,500 ug/ml. A method for eliminating Sicyos angulatus comprises a step of treating Sicyos angulatus, seeds thereof, or a habitat thereof with the herbicidal composition.

    Abstract translation: 目的：提供含有Plumbagin作为预防水preventing鱼的活性成分的组合物，以抑制对植物生长重要的KAPAS（7-酮-8-氨基壬酸合成酶）。 构成：用于预防水ul鱼的除草组合物含有Plumbagin作为活性成分。 Plumbagin衍生自Plumbago auriculata，由化学式1表示。Plumbagin通过以500-2,500ug / ml的浓度处理抑制KAPAS活性。 消除水eliminating鱼的方法包括用除草组合物处理ang鱼，其种子或其栖息地的步骤。

    포도 줄기 껍질로부터 분리된 레스베라트롤 유도체 화합물을 포함하는 항암제 조성물
    4.
    发明公开
    포도 줄기 껍질로부터 분리된 레스베라트롤 유도체 화합물을 포함하는 항암제 조성물 审中-实审
    用于治疗包含来自葡萄膜干燥分离的抑制剂衍生物的癌症的药物组合物

    公开(公告)号：KR1020120116115A

    公开(公告)日：2012-10-22

    申请号：KR1020110033674

    申请日：2011-04-12

    Applicant: 한국화학연구원 ,  국민대학교산학협력단

    Inventor： 최상운 ,  유시용 ,  김영섭 ,  최춘환 ,  최연희 ,  차미란 ,  김영균

    IPC: A61K31/045 ,  A61K31/05 ,  A61K36/87 ,  A23L33/10 ,  A23L33/105 ,  A23L2/52

    CPC classification number: A61K31/045 ,  A23L2/52 ,  A23L33/10 ,  A23L33/105 ,  A61K31/05 ,  A61K36/87 ,  A61K2300/00

    Abstract: PURPOSE: An anticancer drug composition including resveratrol derivative compound separated from grape stem shell is provided to prevent and treat all kinds of cancers including lung cancer, ovarian cancer, melanoma, central nervous system tumor, colon carcinoma, and leukemia. CONSTITUTION: An anticancer drug composition includes vitisinol C, vitisinol E, cis-vitisin A, vitisin B, vitisin C, a pharmaceutically acceptable salt and isomer or a mixture thererof, and grape stem shell extract including thereof as an active ingredient. The grape stem shell extract is obtained by extracting methanol, methanol aqueous solution, ethanol, ethanol aqueous solution, butanol, dichloromethane, ethyl acetate or a mixture thereof. The cancer is lung cancer, ovarian cancer, melanoma or colon carcinoma. A health enhancement food having cancer cell growth inhibition efficacy contains vitisinol C, vitisinol E, cis-viticin A, viticin B, viticin C, pharmaceutically acceptable salt, isomer or a mixture thereof, and grapes stem shell extract including the same. The food is in beverage form. The grape stem shell extract is obtained by the following steps: extracting the grape stem shell by methanol and suspending the obtained extract in distilled water; partitioning thereof by dichloromethane; and extracting the obtained water layer by ethyl acetate.

    Abstract translation: 目的：提供包括从葡萄茎壳分离的白藜芦醇衍生物化合物的抗癌药物组合物，用于预防和治疗各种癌症，包括肺癌，卵巢癌，黑素瘤，中枢神经系统肿瘤，结肠癌和白血病。 构成：抗癌药物组合物包括维生素C，维生素E，顺式维生素A，维生素B，维生素C，其药学上可接受的盐和异构体或其混合物，以及包含它们的葡萄茎壳提取物作为活性成分。 葡萄茎壳提取物是通过提取甲醇，甲醇水溶液，乙醇，乙醇水溶液，丁醇，二氯甲烷，乙酸乙酯或其混合物得到的。 癌症是肺癌，卵巢癌，黑素瘤或结肠癌。 具有癌细胞生长抑制作用的健康增强食品包含维生素C，维生素E，顺式维生素A，维生素B，维生素C，其药学上可接受的盐，异构体或其混合物，以及包含其的葡萄茎壳提取物。 食物是饮料形式。 通过以下步骤获得葡萄茎壳提取物：用甲醇萃取葡萄茎壳，将得到的提取物悬浮于蒸馏水中; 用二氯甲烷分配; 并用乙酸乙酯萃取得到的水层。

    도라지 또는 도라지 추출물로부터의 순도 및 유효 사포닌 함량이 증가된 조사포닌 조성물의 제조방법
    5.
    发明公开
    도라지 또는 도라지 추출물로부터의 순도 및 유효 사포닌 함량이 증가된 조사포닌 조성물의 제조방법 无效
    用于制备柚苷组合物的方法提高纯度和有效的曙光内含物从平板大戟或其提取物

    公开(公告)号：KR1020110012431A

    公开(公告)日：2011-02-09

    申请号：KR1020090070151

    申请日：2009-07-30

    Applicant: 한국화학연구원

    Inventor： 김영섭 ,  유시용 ,  연규환 ,  홍경식 ,  유대석 ,  최연희 ,  최춘환 ,  차미란

    IPC: A61K31/70 ,  A61K36/346

    CPC classification number: A61K31/704 ,  A61K36/346 ,  A61K2236/33 ,  A61K2236/333 ,  A61K2236/55

    Abstract: PURPOSE: A method for preparing crude saponin composition with improved purity and enhanced effective saponin content is provided. CONSTITUTION: A method for preparing crude saponin composition with improved purity and enhanced effective saponin content from platycodon grandiflorum or extract thereof comprises: a step of extracting platycodon grandiflorum using distilled water, low alcohol of C1-C3, ethyl acetate, hexane, dichloromethane or mixture solvent thereof; a step of dissolving the extract in a distilled water and adsorbing saponin ingredient; a step of eluting the adsorbed saponin with ethanol or methanol solution to obtain saponin; and a step of purifying saponin using an organic solvent.

    Abstract translation: 目的：提供一种改善纯度和提高有效皂苷含量的粗皂苷组合物的方法。 制备方法：提供纯化度高，皂甙含量提高的粗皂苷组合物的方法包括：使用蒸馏水，C1-C3，乙酸乙酯，己烷，二氯甲烷或混合物的低级醇提取桔梗的步骤 溶剂; 将提取物溶解在蒸馏水中并吸附皂苷成分的步骤; 用乙醇或甲醇溶液洗脱吸附的皂角苷以获得皂苷的步骤; 和使用有机溶剂提纯皂苷的步骤。

    작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물
    7.
    发明公开
    작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물 有权
    包含提取物的活性成分的药物组合物，其分离物或其分离的化合物作为活性成分

    公开(公告)号：KR1020130083428A

    公开(公告)日：2013-07-22

    申请号：KR1020130081165

    申请日：2013-07-10

    Applicant: 한국화학연구원

    Inventor： 김영섭 ,  유시용 ,  홍경식 ,  최춘환 ,  차미란 ,  박우규

    IPC: A61K31/343 ,  A61K31/045 ,  A61K31/05 ,  A61K36/65

    Abstract: PURPOSE: A Paeonia lactiflora seed extract, a fraction thereof, or a compound isolated therefrom, and a pharmaceutical composition containing the same are provided to suppress the activation of beta-secretase (BECE-1) and to prevent or treat neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neurodegenerative diseases contains one or more kinds of compounds selected among compounds of chemical formulas 1-8, as active ingredients. A method for preparing the compounds of chemical formulas 1-8 comprises the steps of: adding water, C1-C4 alcohols, or a mixture thereof to Paeonia lactiflora seeds and obtaining a Paeonia lactiflora seed extract; fractioning the extract with water, dichloromethane, and ethyl acetate and obtaining a fraction; and isolating compounds by performing silicagel column chromatography of the fraction and purifying the compounds.

    Abstract translation: 目的：提供芍药芍药提取物，其一部分或从其分离的化合物和含有它们的药物组合物以抑制β-分泌酶（BECE-1）的活化并预防或治疗神经变性疾病。 构成：用于预防或治疗神经变性疾病的药物组合物含有选自化学式1-8化合物的一种或多种化合物作为活性成分。 制备化学式1-8的化合物的方法包括以下步骤：将水，C 1 -C 4醇或其混合物加入到芍药芍药种子中并获得芍药提取物; 用水，二氯甲烷和乙酸乙酯分级提取物，得到一部分; 并通过对级分进行硅胶柱色谱法分离化合物并纯化化合物。

    도라지 막분리 추출물을 유효성분으로 함유하는 심근경색의 예방 또는 치료용 약학적 조성물
    9.
    发明公开
    도라지 막분리 추출물을 유효성분으로 함유하는 심근경색의 예방 또는 치료용 약학적 조성물 无效
    用于预防或治疗含有作为活性成分的白藜芦醇的膜分离提取物的心肌梗塞的药物组合物

    公开(公告)号：KR1020110061976A

    公开(公告)日：2011-06-10

    申请号：KR1020090118532

    申请日：2009-12-02

    Applicant: 한국화학연구원

    Inventor： 김은주 ,  김영섭 ,  유시용 ,  차미란 ,  유대석 ,  정이숙

    IPC: A61K36/346 ,  A61P9/10

    Abstract: PURPOSE: A pharmaceutical composition containing Platycodon grandiflorum membrane-separated extract is provided to reduce lipid peroxide concentrate and to prevent or treat myocardial infarcton. CONSTITUTION: A pharmaceutical composition for preventing or treating myocardial infarction contains Platycodon grandiflorum membrane-separated extract as an active ingredient. A method for preparing the extract comprises: a step of adding water, organic solvent, or mixture solvent thereof to Platycodon grandiflorum; and a step of isolating membrane. The organic solvent is alcohol of C1-C4, acetic acid ethyl, methylene chloride or chloroform.

    Abstract translation: 目的：提供含有桔梗大蒜膜分离提取物的药物组合物，以减少脂质过氧化物浓缩物并预防或治疗心肌梗死。 构成：用于预防或治疗心肌梗死的药物组合物含有桔梗膜分离提取物作为活性成分。 制备提取物的方法包括：将水，有机溶剂或其混合溶剂加入到大蒜中的步骤; 和隔离膜的步骤。 有机溶剂是C1-C4，乙酸乙酯，二氯甲烷或氯仿的醇。

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