公开(公告)号：EP0018993A4

公开(公告)日：1980-12-16

申请号：EP79901232

申请日：1980-04-08

Applicant: ABBOTT LAB

Inventor： ALI AKHTAR

IPC: A61K51/00 ,  C07K5/02 ,  C07K5/065 ,  C07K5/093 ,  C07K14/00 ,  G01N33/82 ,  C07C103/52

CPC classification number: G01N33/82 ,  C07K5/0215 ,  C07K5/06078 ,  C07K5/0819 ,  Y10S436/804 ,  Y10S436/815

Abstract: The present invention encompasses compounds A and B, mixtures of A and B and acid addition salts thereof wherein R is hydrogen or loweralkyl having 1-3 carbon atoms, and the phenol ring is labeled with 125I or 131I. The radiolabeled compounds are useful in radiochemical assaying for folic acid.

Abstract translation: 本发明包括化合物A和B，A和B的混合物及其酸加成盐，其中R为氢或具有1-3个碳原子的低级烷基，并且苯酚环用125I或131I标记。 放射性标记的化合物可用于放射化学测定叶酸。

公开(公告)号：EP0556331A4

公开(公告)日：1994-10-12

申请号：EP92901340

申请日：1991-11-08

Applicant: ABBOTT LAB

Inventor： HU ROGER C ,  ROBERTSON EUGENE F ,  MONTGOMERY DEBORAH M ,  PETERSON BRYAN C ,  ALI AKHTAR ,  MACHOWIAK JAMES P ,  GUIDINGER PEGGY L ,  KHALIL OMAR S

IPC: G01N33/532 ,  G01N33/543 ,  G01N33/58 ,  G01N33/536

CPC classification number: G01N33/54306 ,  G01N33/582

Abstract: A chemiluminescent signal amplification method in which the desired reaction signal is amplified by use of a probe reagent which contains an enhancer compound such as a hapten and by the use of a conjugate which contains a chemiluminescent signal generating compound. Kits for performing such an amplified chemiluminescent assay are also provided.

公开(公告)号：EP0018993A1

公开(公告)日：1980-11-26

申请号：EP79901232

申请日：1980-04-08

Applicant: ABBOTT LAB

Inventor： ALI AKHTAR

IPC: A61K51/00 ,  C07K5/02 ,  C07K5/065 ,  C07K5/093 ,  C07K14/00 ,  G01N33/82 ,  C07C103/52

CPC classification number: G01N33/82 ,  C07K5/0215 ,  C07K5/06078 ,  C07K5/0819 ,  Y10S436/804 ,  Y10S436/815

Abstract: La presente invention envisage les composes A et B, des melanges de A et B, ainsi que des sels d'addition d'acide de ceux-ci, dans lesquels R represente l'hydrogene, ou un groupe alkyl inferieur ayant de 1 a 3 atomes de carbone, et le cycle phenol est marque avec 125I ou 131I. Ces composes ainsi marques radioactivement sont utiles dans des essais radiochimiques de l'acide folique:

公开(公告)号：FR2459226A1

公开(公告)日：1981-01-09

申请号：FR8013218

申请日：1980-06-13

Applicant: ABBOTT LAB

Inventor： ALI AKHTAR ,  PLATTNER JACOB JOHN

IPC: C07K5/02 ,  C07K5/083 ,  C07C103/52 ,  G01N33/68

公开(公告)号：FR2471411A1

公开(公告)日：1981-06-19

申请号：FR8025572

申请日：1980-12-02

Applicant: ABBOTT LAB

Inventor： ALI AKHTAR ,  HILTIBRAN ROBERT GLEN

IPC: G01N33/68 ,  C07K1/113 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C12Q1/37 ,  C12Q1/38 ,  G01N33/52

Abstract: This invention relates to the synthesis and use of novel alpha hydroxy tripeptide substrates which are useful in the quantitative determination of proteolytic enzymes such as thrombin and trypsin. In use, the disclosed substrates are hydrolyzed by a proteolytic enzyme to yield a moiety that can be evaluated spectrophotometrically to indicate the quantity of enzyme present.

公开(公告)号：AU650503B2

公开(公告)日：1994-06-23

申请号：AU9104991

申请日：1991-11-08

Applicant: ABBOTT LAB

Inventor： HU ROGER C ,  ROBERTSON EUGENE F ,  MONTGOMERY DEBORAH M ,  PETERSON BRYAN C ,  ALI AKHTAR ,  MACHOWIAK JAMES P ,  GUIDINGER PEGGY L ,  KHALIL OMAR S

IPC: G01N33/532 ,  G01N33/543 ,  G01N33/58 ,  G01N33/536

Abstract: A chemiluminescent signal amplification method in which the desired reaction signal is amplified by use of a probe reagent which contains an enhancer compound such as a hapten and by the use of a conjugate which contains a chemiluminescent signal generating compound. Kits for performing such an amplified chemiluminescent assay are also provided.

公开(公告)号：AU9104991A

公开(公告)日：1992-06-11

申请号：AU9104991

申请日：1991-11-08

Applicant: ABBOTT LAB

Inventor： HU ROGER C ,  ROBERTSON EUGENE F ,  MONTGOMERY DEBORAH M ,  PETERSON BRYAN C ,  ALI AKHTAR ,  MACHOWIAK JAMES P ,  GUIDINGER PEGGY L ,  KHALIL OMAR S

IPC: G01N33/532 ,  G01N33/543 ,  G01N33/58 ,  G01N33/536

Abstract: A chemiluminescent signal amplification method in which the desired reaction signal is amplified by use of a probe reagent which contains an enhancer compound such as a hapten and by the use of a conjugate which contains a chemiluminescent signal generating compound. Kits for performing such an amplified chemiluminescent assay are also provided.

公开(公告)号：CA2095825A1

公开(公告)日：1992-05-10

申请号：CA2095825

申请日：1991-11-08

Applicant: ABBOTT LAB

Inventor： HU ROGER C ,  ROBERTSON EUGENE F ,  MONTGOMERY DEBORAH M ,  PETERSON BRYAN C ,  ALI AKHTAR ,  MACKOWIAK JAMES P ,  GUIDINGER PEGGY L ,  KHALIL OMAR S

IPC: G01N33/532 ,  G01N33/543 ,  G01N33/58 ,  G01N33/53 ,  G01N33/52 ,  G01N21/76

Abstract: 2095825 9208979 PCTABS00013 A chemiluminescent signal amplification method in which the desired reaction signal is amplified by use of a probe reagent which contains an enhancer compound such as a hapten and by the use of a conjugate which contains a chemiluminescent signal generating compound. Kits for performing such an amplified chemiluminescent assay are also provided.

公开(公告)号：DE3045430A1

公开(公告)日：1981-09-03

申请号：DE3045430

申请日：1980-12-02

Applicant: ABBOTT LAB

Inventor： ALI AKHTAR ,  HILTIBRAN ROBERT GLEN

IPC: G01N33/68 ,  C07K1/113 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C12Q1/37 ,  C07C103/52 ,  C12Q1/38

Abstract: This invention relates to the synthesis and use of novel alpha hydroxy tripeptide substrates which are useful in the quantitative determination of proteolytic enzymes such as thrombin and trypsin. In use, the disclosed substrates are hydrolyzed by a proteolytic enzyme to yield a moiety that can be evaluated spectrophotometrically to indicate the quantity of enzyme present.