公开(公告)号：HK1054375A1

公开(公告)日：2003-11-28

申请号：HK03104885

申请日：2003-07-08

Applicant: ABBOTT LAB

Inventor： MICHAEL R SCHRIMPF ,  KARIN R TIETJE ,  RICHARD B TOUPENCE ,  JIANGUO JI ,  ANWER BASHA ,  WILLIAM H BUNNELLE ,  JEROME F DAANEN ,  JENNIFER M PACE ,  KEVIN B SIPPY

IPC: C07D20060101 ,  C07D231/54 ,  A61K31/454 ,  A61K31/4545 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P25/34 ,  C07D471/04 ,  C07D487/04

公开(公告)号：ZA200602274B

公开(公告)日：2007-11-28

申请号：ZA200602274

申请日：2006-03-17

Applicant: ABBOTT LAB

Inventor： ANWER BASHA ,  DART MICHAEL J ,  JIANGUO JI ,  RYTHER KEITH B ,  MORTELL KATHLEEN H ,  SCHRIMPF MICHAEL R ,  BUNNELLE WILLIAM H ,  GALLAGHER MEGAN E ,  PACE JENNIFER M ,  TIETJE KARIN R ,  NERSESIAN DIANA L ,  TAO LI

IPC: A61K20090101 ,  A61K31/435 ,  A61P20090101 ,  A61P25/00 ,  C07D20090101 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5-or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazoyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ±7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：CO4970740A1

公开(公告)日：2000-11-07

申请号：CO98047584

申请日：1998-08-20

Applicant: ABBOTT LAB

Inventor： BLACK LAWRENCE A ,  ANWER BASHA ,  TEODOZYJ KOLOSA ,  KORT MICHAEL E ,  HUAQING LIU ,  MC CARTY CATHERINE M ,  MEENA V PATEL ,  ROHDE JEFFREY J

IPC: A61K31/12 ,  A61K31/38 ,  A61K31/50 ,  C07D237/14 ,  C07D237/18 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D417/06

Abstract: Un compuesto de fórmula I: en dondeX se selecciona del grupo conformadopor O, S, NR4 , N-ORa , y N-NRb Rc , en donde R4 se selecciona del grupo conformado por alquil, alquenil, cicloalquil, cicloalquenil, cicloalquilalquil, cicloalquenilalquil, aril, heterocíclico, heterocíclico alquil, y arilalquil; y Ra , Rb , y Rc se seleccionan independientemente del grupo conformado por alquil, cicloalquil, cicloalquilalquil, aril, y arilalquil; R se selecciona del grupo conformado por alquil, alquenil, alquinil, alquilcarbonilalquil, alquilsulfonilalquil, alquilsulfonilarilalquil, alcoxi, alcoxialquil, carboxi, carboxialquil, cianoalquil, haloalquil, haloalquenil, haloalquinil, hidroxialquil, cicloalquil, cicloalquilalquil, cicloalquenil, cicloalquenilalquil, aril, arilalquil, arilalquenil, arilalquinil, arilalcoxi, arilhaloalquil, arilhidroxialquil, ariloxi, ariloxihidroxialquil, ariloxihaloalquil, arilcarbonilalquil, haloalcoxihidroxialquil, heterocíclico, heterocíclico alquil, heterocíclico alcoxi, heterocíclico oxi, -C(O)R5 , -(CH2 )n C(O)R5 , -R6 -R7 , -(CH2 )n CH(OH)R5 , (CH2 )n CH(ORd )R5 , (CH2 )n C(NORd )R5 , (CH2 )n C(NRd )R5 , -(CH2 )n CH(NORd )R5 , -(CH2 )n CH(NRd Re )R5 , -(CH2 )n CºC-R7 , -(CH2 )n [CH(CX´3 )]m -(CH2 )n -CX´3 , -(CH2 )n (CX´2 )m -(CH2 )n -CX´3 , -(CH2 )n [CH(CX´3 )]m -(CH2 )n R8 , -(CH2 )n (CX´2 )m -(CH2 )n -R8 , (CH2 )n (CHX´)m -(CH2 )n -CX´3 , -(CH2 )n (CHX´)m -(CH2 )n -R8 y -(CH2 )n -R20 , en donde R5 se selecciona del grupo conformado por alquil, alquenil, alquinil, cicloalquil, cicloalquenil, aril, arilalquil, haloalquil, haloalquenil, haloalquinil, heterocíclico, y heterocíclico alquil; en donde R6 es alquileno ó alquenileno, alquileno sustituido con halo ó alquenileno sustituido con halo; ...