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公开(公告)号：WO2004099154A3
公开(公告)日：2005-04-14
申请号：PCT/US2004013530
申请日：2004-04-29
Applicant: ABBOTT LAB , ATKINSON ROBERT N , DRIZEN IRENE , GREGG ROBERT J , GROSS MICHAEL F , KORT MICHAEL E , SHI LEI
Inventor： ATKINSON ROBERT N , DRIZEN IRENE , GREGG ROBERT J , GROSS MICHAEL F , KORT MICHAEL E , SHI LEI
IPC: A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/24 , C07D401/04 , C07D401/12 , A61K31/415
CPC classification number: C07D401/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/24 , C07D401/12
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycle, heterocyclealkyl, heteroaryl, or heteroarylalkyl; R4 is formula (Ia), formula (Ib), formula (Ic), formula (Id), formula (Ie) or formula (If); or formula (II), or a pharmaceutically acceptable salt, amide, ester or prodrug thereof, wherein R14 is formula (III), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX), formula (X), formula (XI), or formula (XII); modulate PN3 in mammals and are useful in treating pain in mammals.
Abstract translation: 式（I）化合物或其药学上可接受的盐，酰胺，酯或前药，其中R 1是烷基，芳基，芳基烷基，环烷基，环烷基烷基，卤代烷基，杂环，杂环烷基，杂芳基或杂芳基烷基; R4是式（Ia），式（Ib），式（Ic），式（Id），式（Ie）或式（If）; 或其药学上可接受的盐，酰胺，酯或前药，其中R 14为式（III），式（IV），式（V），式（VI），式（Ⅶ），式 ），式（IX），式（X），式（XI）或式（XII）; 调节哺乳动物中的PN3，可用于治疗哺乳动物的疼痛。
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公开(公告)号：WO0109096A3
公开(公告)日：2001-08-16
申请号：PCT/US0021054
申请日：2000-08-02
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: C07D249/18 , A61K31/166 , A61K31/17 , A61K31/417 , A61K31/4192 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C275/54 , C07C279/22 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/26 , C07D209/08 , C07D213/74 , C07D213/75 , C07D215/38 , C07D233/02 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12 , C07D407/12 , A61K31/155 , C07C279/30
CPC classification number: C07D213/74 , A61K31/17 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D215/38 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12
Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗钾通道开放剂所预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中打开钾通道的方法。
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3.发明申请
公开(公告)号：WO0024741A3
公开(公告)日：2000-07-13
申请号：PCT/US9925536
申请日：1999-10-28
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , BASHA FATIMA Z , CHEN YIYUAN , KORT MICHAEL E , KYM PHILIP R , TANG RUI , TURNER SEAN C , YI LIN
IPC: C07D487/14 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/4375 , A61P1/00 , A61P9/10 , A61P11/06 , A61P13/00 , A61P15/00 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P43/00 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/153 , C07D495/14 , A61K31/435 , A61K31/47 , C07D487/04
CPC classification number: C07D471/04 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/14
Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗通过钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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公开(公告)号：WO2009055629A3
公开(公告)日：2009-06-11
申请号：PCT/US2008081042
申请日：2008-10-24
Applicant: ABBOTT LAB , GOMTSYAN ARTHUR R , SCHMIDT ROBERT G , BAYBURT EROL K , DAANEN JEROME F , KORT MICHAEL E
Inventor： GOMTSYAN ARTHUR R , SCHMIDT ROBERT G , BAYBURT EROL K , DAANEN JEROME F , KORT MICHAEL E
IPC: C07D213/06 , A61K31/426 , A61K31/44 , A61P29/00 , C07D213/62 , C07D277/22
CPC classification number: C07D213/62 , C07D213/06 , C07D277/22
Abstract: The present invention relates to compounds of formula (I), wherein X, R1, R2, R3, R4, R5, m, and n are defined in the specification are TRPV1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本发明涉及式（I）化合物，其中X，R 1，R 2，R 3，R 4，R 5，m和n在本说明书中定义为TRPV1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：WO02062762A3
公开(公告)日：2003-07-31
申请号：PCT/US0205252
申请日：2002-01-17
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: A61K31/17 , A61K31/275 , A61K31/4164 , A61K31/4406 , A61K31/455 , A61K31/47 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/10 , A61P17/00 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07C233/36 , C07C233/78 , C07C233/83 , C07C255/61 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/20 , C07D209/08 , C07D209/30 , C07D213/40 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
CPC classification number: C07D213/40 , A61K31/17 , A61K31/275 , A61K31/4406 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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Patent Agency Ranking
公开(公告)号：WO0183480A3
公开(公告)日：2002-07-18
申请号：PCT/US0114164
申请日：2001-05-02
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , BASHA FATIMA Z , CHEN YIYUAN , KORT MICHAEL E , KYM PHILIP R , TANG RUI , TURNER SEAN C , YI LIN
IPC: A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4741 , A61K31/4745 , A61P13/02 , A61P15/00 , A61P15/02 , A61P15/10 , A61P21/00 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/63 , C07C205/44 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/14 , A61K31/4353
CPC classification number: C07D471/04 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/14 , C07C47/55
Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗由钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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公开(公告)号：WO0202565A3
公开(公告)日：2002-05-30
申请号：PCT/US0120423
申请日：2001-06-27
Applicant: ABBOTT LAB , LIGAND PHARM INC
Inventor： COGHLAN MICHAEL J , EDWARDS JAMES P , ELMORE STEVEN W , JONES TODD K , KORT MICHAEL E , KYM PHILIP R , MOORE JIMMIE L , PRATT JOHN K , WANG ALAN X
IPC: C07D491/052 , A61K31/4741 , A61K31/519 , A61K31/5377 , A61P29/00 , A61P37/00 , A61P43/00 , C07D491/04 , A61K31/435 , A61K31/505
CPC classification number: C07D491/04
Abstract: Compounds having formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of formula I and methods of inhibiting immune or autoimmune diseases in a mammal.
Abstract translation: 具有式I的化合物可用于部分或完全拮抗，镇压，激动或调节糖皮质激素受体并治疗哺乳动物的免疫，自身免疫和炎性疾病。 还公开了包含式I化合物的药物组合物和在哺乳动物中抑制免疫或自身免疫疾病的方法。
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公开(公告)号：CA2807538A1
公开(公告)日：2012-02-16
申请号：CA2807538
申请日：2010-08-10
Applicant: ABBOTT LAB
Inventor： BAYBURT EROL K , CLAPHAM BRUCE , COX PHIL B , DAANEN JEROME F , GOMTSYAN ARTHUR , KORT MICHAEL E , KYM PHILIP R , VOIGHT ERIC A
IPC: C07D213/30 , A61K31/4402 , A61K31/4433 , A61K31/505 , A61P25/00 , A61P29/00 , C07D239/26 , C07D405/06 , C07D405/08
Abstract: Disclosed herein are modulators of TRPV3 of formula (I), wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
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公开(公告)号：MX2011004081A
公开(公告)日：2011-05-31
申请号：MX2011004081
申请日：2009-10-15
Applicant: ABBOTT LAB
Inventor： KORT MICHAEL E , SCHMIDT ROBERT G , DIDOMENICO STANLEY JR , GOMTSYAN ARTHUR R , PERNER RICHARD J , DAANEN JEROME F , KYM PHILIP R , VOIGHT ERIC A , EROL K BAYBURTU , CHEN JUN , MCDONALD HEATH A
IPC: A61K31/33 , C07D311/74 , A61P19/02 , C07D405/12
Abstract: En la presente invención se describen compuestos de la fórmula (I), o sales farmacéuticamente aceptables, solvatos, profármacos, sales de profármacos o combinaciones de los mismos, en donde R1, R2, R3, R4 y m son tal como se define en la especificación. También se describen composiciones que comprenden dichos compuestos y métodos para tratar condiciones y trastornos utilizando los compuestos y composiciones.
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公开(公告)号：SI1124804T1
公开(公告)日：2006-02-28
申请号：SI9930842
申请日：1999-10-27
Applicant: ABBOTT LAB
Inventor： BLACK LAWRENCE A , BASHA ANWER , KOLASA TEODOZYJ , KORT MICHAEL E , LIU HUAQING , MCCARTY CATHERINE M , PATEL MEENA V , ROHDE JEFFREY J , COGHLAN MICHAEL J , STEWART ANDREW O
IPC: C07D237/00 , A61K31/00 , C07D405/00 , C07D409/00
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