公开(公告)号：AU520644B2

公开(公告)日：1982-02-18

申请号：AU4119778

申请日：1978-10-31

Applicant: ABBOTT LAB

Inventor： TADANIER J S ,  MARTIN J R ,  COLLUM P

IPC: A01N43/14 ,  C07H15/224 ,  C07H15/22 ,  A61K31/71

Abstract: 3-De-O-methyl-2'-N-acyl and alkyl fortimicin B derivatives represented by the formula wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl N,N-diloweralkylaminohydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are antibiotics.

公开(公告)号：SE7812829L

公开(公告)日：1979-06-22

申请号：SE7812829

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S ,  COLLUM P

IPC: A01N43/14 ,  C07H15/224 ,  C07H15/22

Abstract: 3-De-O-methyl-2'-N-acyl and alkyl fortimicin B derivatives represented by the formula wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl N,N-diloweralkylaminohydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are antibiotics.

公开(公告)号：PH14646A

公开(公告)日：1981-10-14

申请号：PH21928

申请日：1978-12-11

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN S ,  MARTIN JERRY R ,  COLLUM P

IPC: A01N43/14 ,  C07H15/224 ,  C07G3/00 ,  C07G11/00 ,  A61K35/00

Abstract: 3-De-O-methyl-2'-N-acyl and alkyl fortimicin B derivatives represented by the formula wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl N,N-diloweralkylaminohydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are antibiotics.

公开(公告)号：SE7812829A

公开(公告)日：1979-06-22

申请号：SE7812829

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S ,  COLLUM P

IPC: A01N43/14 ,  C07H15/224 ,  C07H15/22

CPC classification number: C07H15/224

公开(公告)号：SE7812827L

公开(公告)日：1979-06-22

申请号：SE7812827

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S ,  COLLUM P

IPC: C07H15/224 ,  C07H15/22

Abstract: 2-Deoxyfortimicin, A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.

公开(公告)号：SE7812827A

公开(公告)日：1979-06-22

申请号：SE7812827

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S ,  COLLUM P

IPC: C07H15/224 ,  C07H15/22

CPC classification number: C07H15/224