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    3-DE-P-METHYL-2'-N-ACYL AND ALKYL FORTIMICINS A AND B
    2.
    发明专利
    3-DE-P-METHYL-2'-N-ACYL AND ALKYL FORTIMICINS A AND B 未知

    公开(公告)号：AU520644B2

    公开(公告)日：1982-02-18

    申请号：AU4119778

    申请日：1978-10-31

    Applicant: ABBOTT LAB

    Inventor： TADANIER J S ,  MARTIN J R ,  COLLUM P

    IPC: A01N43/14 ,  C07H15/224 ,  C07H15/22 ,  A61K31/71

    Abstract: 3-De-O-methyl-2'-N-acyl and alkyl fortimicin B derivatives represented by the formula wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl N,N-diloweralkylaminohydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are antibiotics.

    3-DE-0-METHYLFORTIMICINS
    4.
    发明专利
    3-DE-0-METHYLFORTIMICINS 未知

    公开(公告)号：AU517514B2

    公开(公告)日：1981-08-06

    申请号：AU3129277

    申请日：1977-12-07

    Applicant: ABBOTT LAB

    Inventor： MARTIN J R ,  TADANIER J S

    IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  C07H15/22 ,  A61K31/71

    Abstract: Described are 3-de-O-methylfortimicins A and B and 4-N-acyl and 4-N-alkyl-3-de-O-methylfortimicin B derivatives, and their preparation, which compounds are useful as antibiotics or as intermediates for preparing other useful derivatives having antibacterial activity. The compounds have the following structural formula wherein R is hydrogen, acyl, aminoacyl, N-monoloweralkylaminoacyl, N.N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, alkyl, aminoalkyl, N-monoloweralkylaminoalkyl, N.N-diloweralkylaminoalkyl or hydroxy-substituted aminoalkyl and the pharmaceutically acceptable salts thereof, for example, salts formed from hydrochloric, sulfuric, and phosphoric acids.

    6.
    发明专利
    未知

    公开(公告)号：SE7812829L

    公开(公告)日：1979-06-22

    申请号：SE7812829

    申请日：1978-12-13

    Applicant: ABBOTT LAB

    Inventor： MARTIN J R ,  TADANIER J S ,  COLLUM P

    IPC: A01N43/14 ,  C07H15/224 ,  C07H15/22

    Abstract: 3-De-O-methyl-2'-N-acyl and alkyl fortimicin B derivatives represented by the formula wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl N,N-diloweralkylaminohydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are antibiotics.

    9.
    发明专利
    未知

    公开(公告)号：SE7812827L

    公开(公告)日：1979-06-22

    申请号：SE7812827

    申请日：1978-12-13

    Applicant: ABBOTT LAB

    Inventor： MARTIN J R ,  TADANIER J S ,  COLLUM P

    IPC: C07H15/224 ,  C07H15/22

    Abstract: 2-Deoxyfortimicin, A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.

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