公开(公告)号：SE7812828A

公开(公告)日：1979-06-22

申请号：SE7812828

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S

IPC: C07H15/224 ,  C07H15/22

CPC classification number: C07H15/224

公开(公告)号：AU520644B2

公开(公告)日：1982-02-18

申请号：AU4119778

申请日：1978-10-31

Applicant: ABBOTT LAB

Inventor： TADANIER J S ,  MARTIN J R ,  COLLUM P

IPC: A01N43/14 ,  C07H15/224 ,  C07H15/22 ,  A61K31/71

Abstract: 3-De-O-methyl-2'-N-acyl and alkyl fortimicin B derivatives represented by the formula wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl N,N-diloweralkylaminohydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are antibiotics.

公开(公告)号：AU519064B2

公开(公告)日：1981-11-05

申请号：AU2902577

申请日：1977-09-22

Applicant: ABBOTT LAB

Inventor： TADANIER J S ,  MARTIN J R ,  KURATH P

IPC: C07D309/14 ,  A61K31/35 ,  A61K31/351 ,  A61K31/415 ,  A61P31/04 ,  C07D405/12 ,  C07H15/224 ,  C07H15/22 ,  C07H15/26

Abstract: This invention provides 4-N-acylfortimicin B derivatives of the structure wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula where R1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.

公开(公告)号：AU6207080A

公开(公告)日：1981-04-02

申请号：AU6207080

申请日：1980-09-05

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S ,  JOHNSON P

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  C07H15/22

公开(公告)号：SE7812832A

公开(公告)日：1979-06-22

申请号：SE7812832

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： TADANIER J S ,  MARTIN J R

IPC: A01N43/14 ,  C07H15/224 ,  C07H15/22

CPC classification number: C07H15/224

公开(公告)号：SE7812829A

公开(公告)日：1979-06-22

申请号：SE7812829

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S ,  COLLUM P

IPC: A01N43/14 ,  C07H15/224 ,  C07H15/22

CPC classification number: C07H15/224

公开(公告)号：SE7812828L

公开(公告)日：1979-06-22

申请号：SE7812828

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S

IPC: C07H15/224 ,  C07H15/22

Abstract: 2-Deoxy-2'-N-acyl and alkyl fortimicin B and derivatives, 4,2'-N,N'-diacyl and dialkyl fortimicin B derivatives, 4-N-acyl-2'-N-alkyl- and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; and R1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkylaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; and the pharmaceutically acceptable salts therefor, pharmaceutical compositions containing the compounds and methods of making and using the compounds. The compounds of this invention are useful as antibiotics.

公开(公告)号：SE7812826L

公开(公告)日：1979-06-22

申请号：SE7812826

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： TADANIER J S ,  MARTIN J R

IPC: C07H15/224 ,  C07H15/22

Abstract: 6'-Epi-fortimicin A and B derivatives represented by the formula wherein R1 is hydrogen or loweralkyl, R2 is hydrogen or loweralkyl and R3 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, hydroxyloweralkyl, acyl, aminoacyl, hydroxyacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an amino acid residue; the pharmaceutically acceptable salts thereof; intermediates useful in their preparation, compositions employing the compounds; and methods of using the compounds. The compounds are useful as antibiotics.

公开(公告)号：SE7812826A

公开(公告)日：1979-06-22

申请号：SE7812826

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： TADANIER J S ,  MARTIN J R

IPC: C07H15/224 ,  C07H15/22

CPC classification number: C07H15/224

公开(公告)号：AU517514B2

公开(公告)日：1981-08-06

申请号：AU3129277

申请日：1977-12-07

Applicant: ABBOTT LAB

Inventor： MARTIN J R ,  TADANIER J S

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  C07H15/22 ,  A61K31/71

Abstract: Described are 3-de-O-methylfortimicins A and B and 4-N-acyl and 4-N-alkyl-3-de-O-methylfortimicin B derivatives, and their preparation, which compounds are useful as antibiotics or as intermediates for preparing other useful derivatives having antibacterial activity. The compounds have the following structural formula wherein R is hydrogen, acyl, aminoacyl, N-monoloweralkylaminoacyl, N.N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, alkyl, aminoalkyl, N-monoloweralkylaminoalkyl, N.N-diloweralkylaminoalkyl or hydroxy-substituted aminoalkyl and the pharmaceutically acceptable salts thereof, for example, salts formed from hydrochloric, sulfuric, and phosphoric acids.