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公开(公告)号：ZA9704806B
公开(公告)日：1997-12-30
申请号：ZA9704806
申请日：1997-05-30
Applicant: ABBOTT LAB
Inventor： DELLARIA JR JOSEPH F , GANE TODD H , WOODS KEITH W
IPC: A61K20060101 , C07D20060101 , C07D , A61K
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公开(公告)号：DK514688D0
公开(公告)日：1988-09-15
申请号：DK514688
申请日：1988-09-15
Applicant: ABBOTT LAB
Inventor： ROSENBERG SAUL HOWARD , SHAM HING LEUNG , BAKER WILLIAM R , DELLARIA JR JOSEPH F , KEMPF DALE J
IPC: C07C271/10 , A61K31/395 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/535 , A61K31/536 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K38/00 , A61P9/12 , C07C67/00 , C07C69/24 , C07C213/00 , C07C215/10 , C07C215/20 , C07C215/28 , C07C217/08 , C07C217/28 , C07C229/22 , C07C229/26 , C07C229/30 , C07C229/32 , C07C229/34 , C07C229/36 , C07C231/00 , C07C231/02 , C07C233/11 , C07C233/22 , C07C233/40 , C07C233/47 , C07C233/51 , C07C235/20 , C07C237/12 , C07C237/20 , C07C239/20 , C07C255/46 , C07C265/02 , C07C265/04 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/24 , C07C317/28 , C07C317/44 , C07C317/48 , C07C323/24 , C07C323/41 , C07C323/56 , C07C323/59 , C07C323/60 , C07D207/12 , C07D211/76 , C07D213/40 , C07D233/32 , C07D233/61 , C07D263/04 , C07D263/06 , C07D263/16 , C07D263/22 , C07D263/24 , C07D263/28 , C07D265/10 , C07D273/04 , C07D277/24 , C07D285/10 , C07D295/12 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/22 , C07D309/14 , C07D319/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/08 , C07C125/063 , C07C91/02 , C07C101/04 , C07C103/34 , C07C147/06 , C07C149/273 , C07D207/04 , C07D231/12 , C07D233/64 , C07D239/10 , C07D241/02 , C07D263/18 , C07D265/30 , C07D277/30 , C07D291/04 , C07K5/04
Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O, CHOH or NR2 wherein R2 is hydrogen or loweralkyl; U is C=O, CH2 or NR2 wherein R2 is hydrogen or loweralkyl, with the proviso that when W is CHOH then U is CH2 and with the proviso that U is C=O or CH2 when W is NR2; V is CH, C(OH) or C(halogen) with the proviso that V is CH when U is NR2; R1 is loweralkyl, cycloalkylalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-methoxybenzyl, halobenzyl, 4-hydroxybenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (unsubstituted heterocyclic)methyl, (substituted heterocyclic)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino, provided that B is CH2 or CHOH or A is hydrogen when R1 is phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, azidoalkyl, aminoalkyl, (alkyl)aminoalkyl, dialkylaminoalkyl, (alkoxy)(alkyl)aminoalkyl, (alkoxy)aminoalkyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is OH or NH2; and Z is a substituent. Also disclosed are compositions for and a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.
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公开(公告)号：DK514688A
公开(公告)日：1989-03-17
申请号：DK514688
申请日：1988-09-15
Applicant: ABBOTT LAB
Inventor： ROSENBERG SAUL HOWARD , SHAM HING LEUNG , BAKER WILLIAM R , DELLARIA JR JOSEPH F , KEMPF DALE J
IPC: C07C271/10 , A61K31/395 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/535 , A61K31/536 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K38/00 , A61P9/12 , C07C67/00 , C07C69/24 , C07C213/00 , C07C215/10 , C07C215/20 , C07C215/28 , C07C217/08 , C07C217/28 , C07C229/22 , C07C229/26 , C07C229/30 , C07C229/32 , C07C229/34 , C07C229/36 , C07C231/00 , C07C231/02 , C07C233/11 , C07C233/22 , C07C233/40 , C07C233/47 , C07C233/51 , C07C235/20 , C07C237/12 , C07C237/20 , C07C239/20 , C07C255/46 , C07C265/02 , C07C265/04 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/24 , C07C317/28 , C07C317/44 , C07C317/48 , C07C323/24 , C07C323/41 , C07C323/56 , C07C323/59 , C07C323/60 , C07D207/12 , C07D211/76 , C07D213/40 , C07D233/32 , C07D233/61 , C07D263/04 , C07D263/06 , C07D263/16 , C07D263/22 , C07D263/24 , C07D263/28 , C07D265/10 , C07D273/04 , C07D277/24 , C07D285/10 , C07D295/12 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/22 , C07D309/14 , C07D319/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/08 , C07C125/063 , C07C91/02 , C07C101/04 , C07C103/34 , C07C147/06 , C07C149/273 , C07D207/04 , C07D231/12 , C07D233/64 , C07D239/10 , C07D241/02 , C07D263/18 , C07D265/30 , C07D277/30 , C07D291/04 , C07K5/04
Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O, CHOH or NR2 wherein R2 is hydrogen or loweralkyl; U is C=O, CH2 or NR2 wherein R2 is hydrogen or loweralkyl, with the proviso that when W is CHOH then U is CH2 and with the proviso that U is C=O or CH2 when W is NR2; V is CH, C(OH) or C(halogen) with the proviso that V is CH when U is NR2; R1 is loweralkyl, cycloalkylalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-methoxybenzyl, halobenzyl, 4-hydroxybenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (unsubstituted heterocyclic)methyl, (substituted heterocyclic)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino, provided that B is CH2 or CHOH or A is hydrogen when R1 is phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, azidoalkyl, aminoalkyl, (alkyl)aminoalkyl, dialkylaminoalkyl, (alkoxy)(alkyl)aminoalkyl, (alkoxy)aminoalkyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is OH or NH2; and Z is a substituent. Also disclosed are compositions for and a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.
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公开(公告)号：ZA974806B
公开(公告)日：1997-12-30
申请号：ZA974806
申请日：1997-05-30
Applicant: ABBOTT LAB
Inventor： DELLARIA JR JOSEPH F , GANE TODD H , WOODS KEITH W
IPC: A61K20060101 , C07D20060101 , C07D , A61K
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