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公开(公告)号：EP0673254A4
公开(公告)日：1998-11-18
申请号：EP94903367
申请日：1993-11-30
Applicant: ABBOTT LAB
Inventor： GREER JONATHAN , HAVIV FORTUNA , FITZPATRICK TIMOTHY D , SWENSON ROLF E , NICHOLS CHARLES J , MORT NICHOLAS A
Abstract: The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A -D -E -G -J -L -M -Q -R -T . The compounds of the percent invention are characterized by having an OMEGA -amino-functionalized side chain on the D-aminoacyl residue at position 6. The OMEGA -amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.
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公开(公告)号：EP0738154A4
公开(公告)日：1996-04-12
申请号：EP94924100
申请日：1994-07-29
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , FITZPATRICK TIMOTHY D , SWENSON ROLF E , NICHOLS CHARLES J , MORT NICHOLAS A
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3.发明专利
公开(公告)号：HU904911D0
公开(公告)日：1991-01-28
申请号：HU491190
申请日：1990-08-06
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , PALABRICA CHRISTOPHER A , FITZPATRICK TIMOTHY D
Abstract: The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.
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公开(公告)号：CA2022437A1
公开(公告)日：1991-02-08
申请号：CA2022437
申请日：1990-08-01
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , PALABRICA CHRISTOPHER A , FITZPATRICK TIMOTHY D
Abstract: The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.
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公开(公告)号：NO903454D0
公开(公告)日：1990-08-06
申请号：NO903454
申请日：1990-08-06
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , PALABRICA CHRISTOPHER A , FITZPATRICK TIMOTHY D
Abstract: The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.
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Patent Agency Ranking
公开(公告)号：CA2136078A1
公开(公告)日：1994-06-23
申请号：CA2136078
申请日：1993-11-30
Applicant: ABBOTT LAB
Inventor： GREER JONATHAN , HAVIV FORTUNA , FITZPATRICK TIMOTHY D , SWENSON ROLF E , NICHOLS CHARLES J , MORT NICHOLAS A
Abstract: 2136078 9413313 PCTABS00032 The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A1-D2-E3-G4-J5-L6-M7-Q8-R9-T10. The compounds of the percent invention are characterized by having an .OMEGA.-amino-functionalized side chain on the D-aminoacyl residue at position 6. The .OMEGA.-amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.
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公开(公告)号：NO903454A
公开(公告)日：1991-02-08
申请号：NO903454
申请日：1990-08-06
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , PALABRICA CHRISTOPHER A , FITZPATRICK TIMOTHY D
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公开(公告)号：CA2022437C
公开(公告)日：2002-10-22
申请号：CA2022437
申请日：1990-08-01
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , PALABRICA CHRISTOPHER A , FITZPATRICK TIMOTHY D
Abstract: The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.
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公开(公告)号：CA2167834A1
公开(公告)日：1995-02-16
申请号：CA2167834
申请日：1994-07-29
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , FITZPATRICK TIMOTHY D , SWENSEN ROLF E , NICHOLS CHARLES J , MORT NICHOLAS A
IPC: A61K38/00 , A61P5/04 , A61P5/12 , A61P5/28 , A61P5/32 , A61P13/02 , A61P13/08 , A61P15/00 , A61P15/08 , A61P15/18 , A61P25/04 , A61P35/00 , C07K7/06 , C07K7/08 , C07K7/23 , A61K38/09
Abstract: Decapeptide and undecapeptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for hormones the levels of sex hormones in mammals.
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10.发明专利
公开(公告)号：HUT55414A
公开(公告)日：1991-05-28
申请号：HU491190
申请日：1990-08-06
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , PALABRICA CHRISTOPHER A , FITZPATRICK TIMOTHY D
Abstract: The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.
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