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1.发明公开LHRH ANTAGONISTS HAVING MODIFIED AMINOACYL RESIDUES AT POSTIONS 5 AND 6. 失效与LHRH antagoniste修改后的实体TO THE 5位和第6
公开(公告)号：EP0683792A4
公开(公告)日：1998-11-18
申请号：EP94905391
申请日：1993-12-14
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , SWENSON ROLF E , SAUER DARYL R
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公开(公告)号：EP0673254A4
公开(公告)日：1998-11-18
申请号：EP94903367
申请日：1993-11-30
Applicant: ABBOTT LAB
Inventor： GREER JONATHAN , HAVIV FORTUNA , FITZPATRICK TIMOTHY D , SWENSON ROLF E , NICHOLS CHARLES J , MORT NICHOLAS A
Abstract: The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A -D -E -G -J -L -M -Q -R -T . The compounds of the percent invention are characterized by having an OMEGA -amino-functionalized side chain on the D-aminoacyl residue at position 6. The OMEGA -amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.
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公开(公告)号：EP0738154A4
公开(公告)日：1996-04-12
申请号：EP94924100
申请日：1994-07-29
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , FITZPATRICK TIMOTHY D , SWENSON ROLF E , NICHOLS CHARLES J , MORT NICHOLAS A
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公开(公告)号：DE69330838T2
公开(公告)日：2002-04-25
申请号：DE69330838
申请日：1993-12-14
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , SWENSON ROLF E , SAUER DARYL R
Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.
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公开(公告)号：DE69330838D1
公开(公告)日：2001-10-31
申请号：DE69330838
申请日：1993-12-14
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , SWENSON ROLF E , SAUER DARYL R
Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.
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Patent Agency Ranking
公开(公告)号：CA2237298A1
公开(公告)日：1998-03-19
申请号：CA2237298
申请日：1997-09-10
Applicant: ABBOTT LAB
Inventor： SWENSON ROLF E , SOWIN THOMAS J , GRILLOT ANNE-LAURE MARIE , NORBECK DANIEL W , HOCHLOWSKI JILL EDIE
IPC: C07B61/00 , C08F8/00 , C08G85/00 , C40B70/00 , C07C255/49 , C07C63/66 , C07C65/28 , C07C253/30 , C07C255/01 , C07C319/20 , C07C323/62 , C07D239/26 , C07D277/30
Abstract: The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or Raman spectroscopy when directly attached to the support.
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公开(公告)号：MX9308014A
公开(公告)日：1994-08-31
申请号：MX9308014
申请日：1993-12-15
Applicant: ABBOTT LAB
Inventor： SAUER DARYL R , HAVIV FORTUNA , GREET JONATHAN , SWENSON ROLF E
Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.
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公开(公告)号：DK0683792T3
公开(公告)日：2002-01-14
申请号：DK94905391
申请日：1993-12-14
Applicant: ABBOTT LAB
Inventor： HAVIV FORTUNA , GREER JONATHAN , SWENSON ROLF E , SAUER DARYL R
IPC: A61K38/00 , A61P15/00 , C07K7/06 , C07K7/23 , A61K38/04 , C07K7/00 , A61K37/00 , A61K37/02 , A61K37/24 , A61K37/38 , A61K38/09 , A61K38/24 , C07K7/20
Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.
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公开(公告)号：CA2351187A1
公开(公告)日：2000-05-25
申请号：CA2351187
申请日：1999-11-09
Applicant: ABBOTT LAB
Inventor： CRAWFORD BRADLEY W , HAVIV FORTUNA , SWENSON ROLF E , BRUNCKO MILAN , KAMINSKI MICHELE A , DWIGHT WESLEY J , FREY LISA M , DEMATTEI JOHN , GREER JONATHAN
IPC: C07D217/06 , A61K31/472 , A61K31/4725 , A61K31/4741 , A61K31/55 , A61P5/00 , A61P13/08 , A61P15/00 , A61P35/00 , C07D217/04 , C07D217/14 , C07D217/16 , C07D217/18 , C07D217/20 , C07D217/22 , C07D217/26 , C07D223/16 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D491/04 , C07D491/056 , C07D221/00 , C07D317/00 , C07D319/00 , C07D401/10
Abstract: Tetrahydroisoquinoline derivatives of formula (I): or a pharmaceutically acceptable salt, ester, or prodrug thereof, having activity as an LHRH antagonist, as well as pharmaceutical compositions containing the same, and methods for their use and preparation.
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公开(公告)号：AT190049T
公开(公告)日：2000-03-15
申请号：AT97941492
申请日：1997-09-10
Applicant: ABBOTT LAB
Inventor： HOCHLOWSKI JILL EDIE , SOWIN THOMAS J , NORBECK DANIEL W , GRILLOT ANNE-LAURE MARIE , SWENSON ROLF E
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