-
1.发明申请A METHOD FOR INHIBITING ATTACHMENT OF H. INFLUENZAE TO HUMAN CELLS USING PHOSPHORYLATED RECOMBINANT HUMAN BETA-CASEIN 审中-公开使用磷酸化重组人类癌细胞抑制H淋巴细胞对人细胞的附着的方法
公开(公告)号：WO9717085A3
公开(公告)日：1997-08-07
申请号：PCT/US9617860
申请日：1996-11-06
Applicant: ABBOTT LAB
Inventor： MUKERJI PRADIP , THURMOND JENNIFER M , HANSSON LENNART , BAXTER JEFFREY H , HARDS ROBERT G , LEONARD AMANDA EUN-YEONG , ANDERSON STEVEN N , HARVEY LINDA A
IPC: C12N15/09 , A23L1/305 , A61K31/00 , A61K38/00 , A61P27/00 , A61P27/16 , A61P31/00 , A61P31/04 , C07K14/47 , A61K38/17
CPC classification number: C07K14/4732 , A23L33/19 , A61K38/00
Abstract: A method is provided for inhibiting the attachment of H. influenzae to human cells, such as pharyngeal cells, by contacting the bacilli with phosphorylated recombinant human β-casein that have at least 3 phosphate groups. A product containing phosphorylated recombinant human β-casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otitis media in infants. The phosphorylated recombinant human β-casein may also be administered as a throat spray or used in nose drops or a spray.
-
2.发明申请
公开(公告)号：WO9726320A3
公开(公告)日：1997-09-12
申请号：PCT/US9617971
申请日：1996-11-06
Applicant: ABBOTT LAB
Inventor： MUKERJI PRADIP , THURMOND JENNIFER MARIE , HANSSON LENNART , BAXTER JENNIFER HARRIS , HARDS ROBERT GEORGE , LEONARD AMANDA EUN-YEONG , ANDERSON STEVEN NEAL , HARVEY LINDA ANN
IPC: C12N15/09 , A61K31/00 , A61K38/17 , A61P31/00 , A61P31/04 , C07K14/47 , C12N1/21 , C12P21/02 , C12R1/19 , C12N
CPC classification number: A61K38/1709
Abstract: A product is provided for inhibiting the attachment of H. influenzae to human cells, such as pharyngeal cells, by contacting the bacilli with phosphorylated recombinant human beta -casein that have at least 3 phosphate groups. The product containing phosphorylated recombinant human beta -casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otitis media in infants. The phosphorylated recombinant human beta -casein may also be administered as a throat spray or used in nose drops or a spray. 00000
Abstract translation: 通过使杆菌与具有至少3个磷酸基团的磷酸化重组人β-酪蛋白接触，提供了用于抑制流感嗜血杆菌与人细胞如咽细胞的连接的产物。 含有磷酸化重组人β-酪蛋白的产品可以是液体肠内营养产品，例如婴儿配方食品。 肠内营养产品可用于预防和治疗婴幼儿中耳炎。 磷酸化重组人β-酪蛋白也可以作为咽喉喷雾剂施用或用于鼻滴或喷雾剂中。 00000
-
3.发明专利
公开(公告)号：NZ322727A
公开(公告)日：1999-07-29
申请号：NZ32272796
申请日：1996-11-06
Applicant: ABBOTT LAB , SYMBICOM AB
Inventor： MUKERJI PRADIP , THURMOND JENNIFER MARIE , HANSSON LENNART , BAXTER JEFFREY HARRIS , HARDS ROBERT GEORGE
IPC: A23J1/20 , A61K31/00 , A61K38/00 , A23L1/305 , A61K38/17 , A61P31/00 , A61P31/04 , C07K14/47 , C12N1/21 , C12N9/12 , C12N15/09 , C12N15/62 , C12N15/64 , C12N15/70 , C12P21/00 , C12R1/07 , C12R1/19 , C12R1/225 , C12R1/46 , C12P21/02
Abstract: The present invention provides a method of producing phophorylated, recombinant human beta -casein having 3 to 5 phosphates in a bacterial cell using a single vector containing in tandem both the nucleotide sequence encoding beta -casein and a sequence encoding the enzyme CKII beta alpha which is capable of phosphorylating human beta -casein.
-
公开(公告)号：AU1158197A
公开(公告)日：1997-08-11
申请号：AU1158197
申请日：1996-11-06
Applicant: ABBOTT LAB
-
公开(公告)号：CA2213734A1
公开(公告)日：1996-09-06
申请号：CA2213734
申请日：1996-02-27
Applicant: ABBOTT LAB
Inventor： HANSSON LENNART , THURMOND JENNIFER MARIE , MUKERJI PRADIP , HARDS ROBERT GEORGE , BAXTER JEFFREY HARRIS
IPC: C12N15/09 , A61K38/17 , A61P37/00 , A61P43/00 , C07K14/47 , C12N1/21 , C12N9/12 , C12N15/62 , C12N15/64 , C12N15/67 , C12N15/70 , C12P21/02 , C12R1/19 , C12N15/12 , C12N15/54
Abstract: The present invention provides a plasmid containing a promoter sequence, a nucleotide sequence encoding an exogenous protein, and a nucleotide sequence encoding an enzyme capable of modifying the exogenous protein. In a specific embodiment of the invention the encoded exogenous protein is human .beta.casein and the encoded enzyme is a human kinase capable of phosphorylating recombinant .beta.-casein in a bacterial system.
-
Patent Agency Ranking6.发明专利
公开(公告)号：AU7669396A
公开(公告)日：1997-05-29
申请号：AU7669396
申请日：1996-11-06
Applicant: ABBOTT LAB
Inventor： MUKERJI PRADIP , THURMOND JENNIFER MARIE , HANSSON LENNART , BAXTER JEFFREY HARRIS , HARDS ROBERT GEORGE
IPC: A23L1/305 , A23J1/20 , A61K31/00 , A61K38/00 , A61K38/17 , A61P31/00 , A61P31/04 , C07K14/47 , C12N1/21 , C12N9/12 , C12N15/09 , C12N15/62 , C12N15/64 , C12N15/70 , C12P21/00 , C12R1/07 , C12R1/19 , C12R1/225 , C12R1/46 , C12N15/12
Abstract: The present invention provides a method of producing phophorylated, recombinant human beta -casein having 3 to 5 phosphates in a bacterial cell using a single vector containing in tandem both the nucleotide sequence encoding beta -casein and a sequence encoding the enzyme CKII beta alpha which is capable of phosphorylating human beta -casein.
-
公开(公告)号：MX9803565A
公开(公告)日：1998-09-30
申请号：MX9803565
申请日：1998-05-06
Applicant: ABBOTT LAB
Inventor： MUKERJI PRADIP , THURMOND JENNIFER M , HANSSON LENNART , BAXTER JEFFREY H , HARDS ROBERT G , LEONARD AMANDA EUN-YEONG , ANDERSON STEVEN M , HARVEY LINDA A
IPC: C12N15/09 , A23L1/305 , A61K31/00 , A61K38/00 , A61P27/00 , A61P27/16 , A61P31/00 , A61P31/04 , C07K14/47 , A61K38/17 , A23L01/305
Abstract: Se provee un método para inhibir la union de H, influenzae a células humanas, tales como células faringeas, poniendo en contacto los bacilos con beta-caseina humana, recombinante, fosforilada, que tiene por lo menos 3 grupos fosfato. Un producto que contiene la beta-caseina humana, recombinante, fosforilada puede ser un producto nutricional enteral líquido, tal como una formula infantil. EL producto nutricional enteral puede ser utilizado para la prevencion y el tratamiento de otitis media en bebés. La beta-caseina humana, recombinante, fosforilada también puede ser administrada como una aspersion para la garganta o usarse en gotas para la nariz o una aspersion.
-
公开(公告)号：CA2234664A1
公开(公告)日：1997-05-15
申请号：CA2234664
申请日：1996-11-06
Applicant: ABBOTT LAB , SYMBICOM AB
Inventor： THURMOND JENNIFER M , HANSSON LENNART , MUKERJI PRADIP , BAXTER JEFFREY H , ANDERSON STEVEN N , HARVEY LINDA A , LEONARD AMANDA EUN-YEONG , HARDS ROBERT G
IPC: A23C9/152 , A23C9/20 , A23L33/18 , A61K38/17 , C07K14/47 , C12N15/12 , C12N15/63 , C12P21/02 , A23L1/305
Abstract: A method is provided for inhibiting the attachment of H. influenzae to human cells, such as pharyngeal cells, by contacting the bacilli with phosphorylated recombinant human .beta.-casein that have at least 3 phosphate groups. A product containing phosphorylated recombinant human .beta.-casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otitis media in infants. The phosphorylated recombinant human .beta.-casein may also be administered as a throat spray or used in nose drops or a spray.
-
公开(公告)号：AT246934T
公开(公告)日：2003-08-15
申请号：AT96942738
申请日：1996-11-06
Applicant: ABBOTT LAB
-
10.发明专利
公开(公告)号：CA2234683A1
公开(公告)日：1997-05-15
申请号：CA2234683
申请日：1996-11-06
Applicant: ABBOTT LAB
Inventor： THURMOND JENNIFER MARIE , HANSSON LENNART , BAXTER JEFFREY HARRIS , MUKERJI PRADIP , HARDS ROBERT GEORGE
IPC: A23L1/305 , A23J1/20 , A61K31/00 , A61K38/00 , A61K38/17 , A61P31/00 , A61P31/04 , C07K14/47 , C12N1/21 , C12N9/12 , C12N15/09 , C12N15/62 , C12N15/64 , C12N15/70 , C12P21/00 , C12R1/07 , C12R1/19 , C12R1/225 , C12R1/46 , C12P21/02 , A23C9/20
Abstract: The present invention provides a method of producing phosphorylated, recombinant human .beta.-casein having 3 to 5 phosphates in a bacterial cell using a single vector containing in tandem both the nucleotide sequence encoding .beta.-casein and a sequence encoding the enzyme CKII .beta..alpha. which is capable of phosphorylating human .beta.-casein.
-
-
-
-
-
-
-
-
-
Search Results
15
records
(took 0.02 seconds)
