公开(公告)号：JP2011139703A

公开(公告)日：2011-07-21

申请号：JP2011014983

申请日：2011-01-27

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： MUKERJI PRADIP ,  LEONARD AMANDA EUN-YEONG ,  HUANG YUNG-SHENG ,  THURMOND JENNIFER ,  KIRCHNER STEPHEN J ,  PARKER-BARNES JENNIFER M ,  DAS TAPAS

IPC: A01H5/00 ,  C12N15/09 ,  A01K67/027 ,  A23C11/02 ,  A23D9/00 ,  A23K1/14 ,  A23K1/16 ,  A23K1/175 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/60 ,  A61K8/64 ,  A61K31/201 ,  A61K31/202 ,  A61K38/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  A61K47/36 ,  A61P1/04 ,  A61P3/02 ,  A61P3/06 ,  A61P3/10 ,  A61P3/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P21/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61Q19/00 ,  C12N1/14 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N15/54 ,  C12N15/82 ,  C12P7/40 ,  C12P7/64 ,  C12R1/645 ,  C12R1/865

CPC classification number: A61K8/361 ,  A01K2217/05 ,  A23D9/00 ,  A23K20/158 ,  A61K8/606 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61K2800/86 ,  A61Q19/00 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472

Abstract: PROBLEM TO BE SOLVED: To identify four genes involved in an elongation of polyunsaturated acid (i.e., "elongase"); and to provide a use thereof. SOLUTION: Two of four genes involved in an elongation of polyunsaturated acid (i.e., "elongase") are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogama linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid, added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：鉴定涉及多不饱和酸延伸的四个基因（即“延长酶”）; 并提供其使用。 解决方案：涉及多不饱和酸延伸的四个基因中的两个（即“延长酶”）也参与单不饱和脂肪酸的延伸。 特别地，延长酶用于将γ-亚麻酸（GLA）转化为二氨基亚麻酸（DGLA）和将DGLA或20：4n-3转化为二十碳五烯酸（EPA）。 DGLA可以用于生产多不饱和脂肪酸，例如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，ω6-二十二碳烯酸或ω3-二十二碳五烯酸，添加到药物组合物，营养组合物，动物 饲料，以及化妆品等其他产品。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：WO9823762A3

公开(公告)日：1998-10-29

申请号：PCT/US9722095

申请日：1997-11-24

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  HARDS ROBERT GEORGE ,  THURMOND JENNIFER MARIE ,  LEONARD AMANDA EUN-YEONG

IPC: C12N15/09 ,  C07K14/47 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/48 ,  C12N15/62 ,  C12P21/06 ,  C12N15/55

CPC classification number: C12N15/62 ,  C07K14/4732 ,  C07K2319/00 ,  C12N9/48 ,  C12P21/06

Abstract: The subject invention relates to methods of processing and producing recombinant proteins in vivo, for example, recombinant phosphorylated beta-casein. The subject invention also relates to the proteins produced by these methods as well as to uses of these proteins.

公开(公告)号：WO0208401A3

公开(公告)日：2003-03-13

申请号：PCT/US0123259

申请日：2001-07-24

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  DAS TAPAS ,  HUANG YUNG-SHENG ,  PARKER-BARNES JENNIFER M ,  LEONARD AMANDA EUN-YEONG ,  THURMOND JENNIFER ,  PEREIRA SUZETTE L

IPC: A01H5/00 ,  A01K67/027 ,  A23C9/158 ,  A23D9/00 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/60 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61P3/02 ,  A61P9/00 ,  A61P43/00 ,  A61Q19/00 ,  C07C57/03 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12R1/865 ,  A23L1/29 ,  A61K7/00 ,  A61K31/20

CPC classification number: C12N9/1029 ,  A01K2217/05 ,  A23D9/00 ,  A23K20/158 ,  A61K8/361 ,  A61K8/606 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61K2800/86 ,  A61Q19/00 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472

Abstract: The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, w6-docosapentaenoic acid or w3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

Abstract translation: 本发明涉及鉴定涉及多不饱和酸延伸的几种基因（即“延伸酶”）及其应用。 这些基因中至少有两个也参与单不饱和脂肪酸的延伸。 特别地，延长酶用于将γ-亚麻酸（GLA）转化为二亚麻酸亚麻酸（DGLA）和将DGLA或20：4n-3转化为二十碳五烯酸（EPA）。 DGLA可用于生产多不饱和脂肪酸，例如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，w6-二十二碳五烯酸或w3-二十二碳五烯酸，其可加入到药物组合物中，营养组合物 ，动物饲料，以及化妆品等其他产品。

公开(公告)号：WO0008174A9

公开(公告)日：2000-08-03

申请号：PCT/US9917873

申请日：1999-08-06

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  LEMMEL STEVEN A ,  LEONARD AMANDA EUN-YEONG ,  CHAUDHARY SUNITA

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N9/48 ,  C12N15/54 ,  C12N15/62 ,  C12N15/70 ,  C12P21/06 ,  A61K38/16 ,  C12N15/57

CPC classification number: C12N9/48 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4732 ,  C07K2319/00 ,  C12N15/62 ,  C12N15/70 ,  C12P21/06

Abstract: The subject invention relates to beta -casein expressing constructs which have significant stability when introduced into host cells. These constructs, for purposes of the present invention, have been designated as pRAB-84-69 and pRSB-14.

Abstract translation: 本发明涉及表达β-酪蛋白的构建体，其在导入宿主细胞时具有显着的稳定性。 为了本发明的目的，这些构建体已被命名为pRAB-84-69和pRSB-14。

公开(公告)号：WO02090493A3

公开(公告)日：2003-10-16

申请号：PCT/US0213589

申请日：2002-05-02

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  HUANG YUNG-SHENG ,  DAS TAPAS ,  THURMOND JENNIFER M ,  LEONARD AMANDA EUN-YEONG ,  PEREIRA SUZETTE L

IPC: A01H5/00 ,  A23D9/00 ,  A23K1/16 ,  A23L1/164 ,  A23L1/187 ,  A61K31/202 ,  A61K38/00 ,  A61P3/02 ,  C12N1/19 ,  C12N5/02 ,  C12N5/10 ,  C12N9/02 ,  C12N15/09 ,  C12P7/64 ,  A01H1/00 ,  A61K31/20 ,  C07C53/00 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

CPC classification number: C12N9/0083 ,  A23D9/00 ,  A23K20/158 ,  A23L7/126 ,  A23L9/12 ,  A61K38/00 ,  C12P7/6427 ,  C12P7/6472

Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., "Delta4-desaturase"). In particular, Delta4-desaturase may be utilized, for example, in the conversion of adrenic acid to omega6-docosapentaenoic acid and in the conversion of omega3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

Abstract translation: 本发明涉及鉴定涉及碳4处多不饱和脂肪酸去饱和的基因（即“Δ4-去饱和酶”）。 特别地，可以使用Δ4-去饱和酶，例如，将肾上腺酸转化为ω6-二十二碳五烯酸，并将ω3-二十二碳五烯酸转化成二十二碳六烯酸。 通过使用酶产生的多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。

公开(公告)号：WO9717085A3

公开(公告)日：1997-08-07

申请号：PCT/US9617860

申请日：1996-11-06

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  THURMOND JENNIFER M ,  HANSSON LENNART ,  BAXTER JEFFREY H ,  HARDS ROBERT G ,  LEONARD AMANDA EUN-YEONG ,  ANDERSON STEVEN N ,  HARVEY LINDA A

IPC: C12N15/09 ,  A23L1/305 ,  A61K31/00 ,  A61K38/00 ,  A61P27/00 ,  A61P27/16 ,  A61P31/00 ,  A61P31/04 ,  C07K14/47 ,  A61K38/17

CPC classification number: C07K14/4732 ,  A23L33/19 ,  A61K38/00

Abstract: A method is provided for inhibiting the attachment of H. influenzae to human cells, such as pharyngeal cells, by contacting the bacilli with phosphorylated recombinant human β-casein that have at least 3 phosphate groups. A product containing phosphorylated recombinant human β-casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otitis media in infants. The phosphorylated recombinant human β-casein may also be administered as a throat spray or used in nose drops or a spray.

公开(公告)号：EP1401259A4

公开(公告)日：2005-06-22

申请号：EP02731579

申请日：2002-05-02

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  HUANG YUNG-SHENG ,  DAS TAPAS ,  THURMOND JENNIFER M ,  LEONARD AMANDA EUN-YEONG ,  PEREIRA SUZETTE L

IPC: A01H5/00 ,  A23D9/00 ,  A23K1/16 ,  A23L1/164 ,  A23L1/187 ,  A61K31/202 ,  A61K38/00 ,  A61P3/02 ,  C12N1/19 ,  C12N5/02 ,  C12N5/10 ,  C12N9/02 ,  C12N15/09 ,  C12P7/64 ,  A01H1/00 ,  A61K31/20 ,  C07C53/00 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

CPC classification number: C12N9/0083 ,  A23D9/00 ,  A23K20/158 ,  A23L7/126 ,  A23L9/12 ,  A61K38/00 ,  C12P7/6427 ,  C12P7/6472

Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., 'Δ4-desaturase'). In particular, Δ4-desaturase may be utilized, for example, in the conversion of adrenic acid to ω6-docosapentaenoic acid and in the conversion of ω3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

公开(公告)号：WO0012720A9

公开(公告)日：2001-04-19

申请号：PCT/US9919715

申请日：1999-08-30

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  LEONARD AMANDA EUN-YEONG ,  HUANG YUNG-SHENG ,  THURMOND JENNIFER ,  KIRCHNER STEPHEN J ,  PARKER-BARNES JENNIFER M ,  DAS TAPAS

IPC: A01H5/00 ,  A01K67/027 ,  A23C11/02 ,  A23D9/00 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/60 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61P1/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P21/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61Q19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12R1/645 ,  C12R1/865 ,  A23L1/29 ,  A61K7/00 ,  A61K31/20 ,  C12N1/15

CPC classification number: A61K8/361 ,  A01K2217/05 ,  A23D9/00 ,  A23K20/158 ,  A61K8/606 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61K2800/86 ,  A61Q19/00 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472

Abstract: The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogama linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, omega 6-docosapentaenoic acid or omega 3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

Abstract translation: 本发明涉及鉴定涉及多不饱和酸延伸的四种基因（即“延伸酶”）及其应用。 这些基因中的两个也参与单不饱和脂肪酸的延伸。 特别地，延长酶用于将γ-亚麻酸（GLA）转化为二甘油亚麻酸（DGLA）和将DGLA或20：4n-3转化成二十碳五烯酸（EPA）。 DGLA可用于生产多不饱和脂肪酸，例如可加入到药物组合物中的花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，ω-二十二碳五烯酸或ω-二十二碳五烯酸， 营养组合物，动物饲料，以及其他产品如化妆品。

公开(公告)号：WO0012720A8

公开(公告)日：2000-10-19

申请号：PCT/US9919715

申请日：1999-08-30

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  LEONARD AMANDA EUN-YEONG ,  HUANG YUNG-SHENG ,  THURMOND JENNIFER ,  KIRCHNER STEPHEN J ,  PARKER-BARNES JENNIFER M ,  DAS TAPAS

IPC: A01H5/00 ,  A01K67/027 ,  A23C11/02 ,  A23D9/00 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/60 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61P1/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P21/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61Q19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12R1/645 ,  C12R1/865 ,  A23L1/29 ,  A61K7/00 ,  A61K31/20 ,  C12N1/15

CPC classification number: A61K8/361 ,  A01K2217/05 ,  A23D9/00 ,  A23K20/158 ,  A61K8/606 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61K2800/86 ,  A61Q19/00 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472

Abstract: The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogama linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, omega 6-docosapentaenoic acid or omega 3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

Abstract translation: 本发明涉及鉴定涉及多不饱和酸延伸的四种基因（即“延伸酶”）及其用途。 这些基因中的两个也参与单不饱和脂肪酸的延伸。 特别地，延长酶用于将γ-亚麻酸（GLA）转化为二氨基亚麻酸（DGLA）和将DGLA或20：4n-3转化为二十碳五烯酸（EPA）。 DGLA可用于生产多不饱和脂肪酸，例如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，ω6-二十二碳五烯酸或ω-3-二十二碳五烯酸，其可加入到药物组合物中， 营养组合物，动物饲料，以及其他产品如化妆品。

公开(公告)号：WO0012720A2

公开(公告)日：2000-03-09

申请号：PCT/US9919715

申请日：1999-08-30

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  LEONARD AMANDA EUN-YEONG ,  HUANG YUNG-SHENG ,  THURMOND JENNIFER ,  KIRCHNER STEPHEN J ,  PARKER-BARNES JENNIFER M ,  DAS TAPAS

IPC: A01H5/00 ,  A01K67/027 ,  A23C11/02 ,  A23D9/00 ,  A23K1/16 ,  A23L1/30 ,  A61K8/30 ,  A61K8/36 ,  A61K8/60 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61P1/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P21/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61Q19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12N15/82 ,  C12P7/64 ,  C12R1/645 ,  C12R1/865 ,  A23L1/29 ,  A61K7/00 ,  A61K31/20 ,  C12N1/15

CPC classification number: A61K8/361 ,  A01K2217/05 ,  A23D9/00 ,  A23K20/158 ,  A61K8/606 ,  A61K8/64 ,  A61K31/202 ,  A61K38/00 ,  A61K2800/86 ,  A61Q19/00 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472

Abstract: The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogama linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, omega 6-docosapentaenoic acid or omega 3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

Abstract translation: 本发明涉及鉴定涉及多不饱和酸（即“延长酶”）延长的四种基因及其用途。 其中两个基因也参与单不饱和脂肪酸的延长。 具体而言，延长酶用于将γ-亚麻酸（GLA）转化为二氢马来亚麻酸（DGLA）并将DGLA或20：4n-3转化为二十碳五烯酸（EPA）。 DGLA可以用于生产多不饱和脂肪酸，如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺酸，ω6-二十二碳五烯酸或ω3-二十二碳五烯酸，其可以加入到药物组合物中， 营养组合物，动物饲料以及其他产品如化妆品。