公开(公告)号：WO9717085A3

公开(公告)日：1997-08-07

申请号：PCT/US9617860

申请日：1996-11-06

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  THURMOND JENNIFER M ,  HANSSON LENNART ,  BAXTER JEFFREY H ,  HARDS ROBERT G ,  LEONARD AMANDA EUN-YEONG ,  ANDERSON STEVEN N ,  HARVEY LINDA A

IPC: C12N15/09 ,  A23L1/305 ,  A61K31/00 ,  A61K38/00 ,  A61P27/00 ,  A61P27/16 ,  A61P31/00 ,  A61P31/04 ,  C07K14/47 ,  A61K38/17

CPC classification number: C07K14/4732 ,  A23L33/19 ,  A61K38/00

Abstract: A method is provided for inhibiting the attachment of H. influenzae to human cells, such as pharyngeal cells, by contacting the bacilli with phosphorylated recombinant human β-casein that have at least 3 phosphate groups. A product containing phosphorylated recombinant human β-casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otitis media in infants. The phosphorylated recombinant human β-casein may also be administered as a throat spray or used in nose drops or a spray.

公开(公告)号：MX9803565A

公开(公告)日：1998-09-30

申请号：MX9803565

申请日：1998-05-06

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  THURMOND JENNIFER M ,  HANSSON LENNART ,  BAXTER JEFFREY H ,  HARDS ROBERT G ,  LEONARD AMANDA EUN-YEONG ,  ANDERSON STEVEN M ,  HARVEY LINDA A

IPC: C12N15/09 ,  A23L1/305 ,  A61K31/00 ,  A61K38/00 ,  A61P27/00 ,  A61P27/16 ,  A61P31/00 ,  A61P31/04 ,  C07K14/47 ,  A61K38/17 ,  A23L01/305

Abstract: Se provee un método para inhibir la union de H, influenzae a células humanas, tales como células faringeas, poniendo en contacto los bacilos con beta-caseina humana, recombinante, fosforilada, que tiene por lo menos 3 grupos fosfato. Un producto que contiene la beta-caseina humana, recombinante, fosforilada puede ser un producto nutricional enteral líquido, tal como una formula infantil. EL producto nutricional enteral puede ser utilizado para la prevencion y el tratamiento de otitis media en bebés. La beta-caseina humana, recombinante, fosforilada también puede ser administrada como una aspersion para la garganta o usarse en gotas para la nariz o una aspersion.

公开(公告)号：CA2234664A1

公开(公告)日：1997-05-15

申请号：CA2234664

申请日：1996-11-06

Applicant: ABBOTT LAB ,  SYMBICOM AB

Inventor： THURMOND JENNIFER M ,  HANSSON LENNART ,  MUKERJI PRADIP ,  BAXTER JEFFREY H ,  ANDERSON STEVEN N ,  HARVEY LINDA A ,  LEONARD AMANDA EUN-YEONG ,  HARDS ROBERT G

IPC: A23C9/152 ,  A23C9/20 ,  A23L33/18 ,  A61K38/17 ,  C07K14/47 ,  C12N15/12 ,  C12N15/63 ,  C12P21/02 ,  A23L1/305

Abstract: A method is provided for inhibiting the attachment of H. influenzae to human cells, such as pharyngeal cells, by contacting the bacilli with phosphorylated recombinant human .beta.-casein that have at least 3 phosphate groups. A product containing phosphorylated recombinant human .beta.-casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otitis media in infants. The phosphorylated recombinant human .beta.-casein may also be administered as a throat spray or used in nose drops or a spray.

公开(公告)号：NZ322369A

公开(公告)日：1999-11-29

申请号：NZ32236996

申请日：1996-11-06

Applicant: ABBOTT LAB ,  SYMBICOM AB

Inventor： MUKERJI PRADIP ,  THURMOND JENNIFER M ,  HANSSON LENNART ,  BAXTER JEFFREY H ,  HARDS ROBERT G ,  LEONARD AMANDA EUN-YEONG ,  ANDERSON STEVEN N ,  HARVEY LINDA A

IPC: C12N15/09 ,  A23L1/305 ,  A61K31/00 ,  A61K38/00 ,  A61P27/00 ,  A61P27/16 ,  A61P31/00 ,  A61P31/04 ,  C07K14/47 ,  A61K38/17 ,  A23C11/08

Abstract: A method is provided for inhibiting the attachment of Haemophilus influenzae to human pharyngeal cells by contacting the bacilli with phosphorylated recombinant human b-casein that have at least 3 phosphate groups. A product containing phosphorylated recombinant human b-casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otis media in infants. The phosphorylated recombinant human b-casein may also be administrated as a throat spray or used in nose drops or spray.

公开(公告)号：AU7610496A

公开(公告)日：1997-05-29

申请号：AU7610496

申请日：1996-11-06

Applicant: ABBOTT LAB

Inventor： MUKERJI PRADIP ,  THURMOND JENNIFER M ,  HANSSON LENNART ,  BAXTER JEFFREY H ,  HARDS ROBERT G ,  LEONARD AMANDA EUN-YEONG ,  ANDERSON STEVEN N ,  HARVEY LINDA A

IPC: C12N15/09 ,  A23L1/305 ,  A61K31/00 ,  A61K38/00 ,  A61P27/00 ,  A61P27/16 ,  A61P31/00 ,  A61P31/04 ,  C07K14/47 ,  A61K38/17