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公开(公告)号：EP0588785A4
公开(公告)日：1991-12-30
申请号：EP90906504
申请日：1990-03-20
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , SUMMERS JAMES B , KERKMAN DANIEL J , MARTIN JONATHAN G
IPC: C12N9/99 , A61K31/17 , A61K31/195 , A61K31/22 , A61K31/275 , A61K31/38 , A61K31/381 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C275/64 , C07C323/44 , C07C323/47 , C07C335/40 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/32 , C07D333/36 , C07D335/08 , C07D409/04 , C07D409/06 , C07D409/12 , C07D307/81
CPC classification number: C07D409/04 , C07C275/64 , C07C323/47 , C07D333/36 , C07D335/08 , C07D409/06 , C07D409/12
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公开(公告)号：MX9204108A
公开(公告)日：1993-08-01
申请号：MX9204108
申请日：1992-07-14
Applicant: ABBOTT LAB
Inventor： ZYDOWSKY THOMAS M , KERKMAN DANIEL J , DEBERNARDIS JOHN F , ROSENBERG SAUL H , BASHA KAZUMI SHIOSAKI FATIMA Z , KESTER ANDREW S TASKER JEFFREY , GELDERN THOMAS W VON , HOLLEMAN WILLIAM H , DE MARTIN WINN BISWANATH
IPC: A61K31/44
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公开(公告)号：MX9204051A
公开(公告)日：1993-08-01
申请号：MX9204051
申请日：1991-07-11
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , KERKMAN DANIEL J , BHATIA PRAMILA A , BASHA ANWER , MARTIN JONATHAN G
IPC: A61K31/44
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公开(公告)号：CA2050597A1
公开(公告)日：1990-10-01
申请号：CA2050597
申请日：1990-03-20
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , SUMMERS JAMES B , KERKMAN DANIEL J , MARTIN JONATHAN G
IPC: C12N9/99 , A61K31/17 , A61K31/195 , A61K31/22 , A61K31/275 , A61K31/38 , A61K31/381 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C275/64 , C07C323/44 , C07C323/47 , C07C335/40 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/32 , C07D333/36 , C07D335/08 , C07D409/04 , C07D409/06 , C07D409/12 , A61K31/33 , C07D333/04 , C07D335/06 , C07D409/02 , C07F7/18
Abstract: 2050597 9012008 PCTABS00002 Substituted phenyl, naphthyl, and thienyl N-hydroxy urea compounds form a class of potent inhibitors of 5- and 12-lipoxygenase and are thus useful compounds in the treatment of inflammatory disease states where leukotrienes and other products of lipoxygenase enzyme activity are implicated.
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公开(公告)号：ES2095325T3
公开(公告)日：1997-02-16
申请号：ES91915194
申请日：1991-07-11
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , KERKMAN DANIEL J , BHATIA PRAMILA A , BASHA ANWER , MARTIN JONATHAN G
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07C271/40 , C07D213/42 , C07D215/14 , C07D263/58
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Patent Agency Ranking
公开(公告)号：AU8374491A
公开(公告)日：1992-03-12
申请号：AU8374491
申请日：1991-09-09
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , KESTER JEFFREY A , HOLLEMAN WILLIAM H , DE BISWANATH , ZYDOWSKY THOMAS M , KERKMAN DANIEL J , DEBERNARDIS JOHN F , ROSENBERG SAUL H , SHIOSAKI KAZUMI , BASHA FATIMA Z , TASKER ANDREW S , GELDERN THOMAS W VON
IPC: A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/53 , A61P1/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P27/02 , A61P43/00 , C07D213/64 , C07D213/70 , C07D213/71 , C07D213/72 , C07D213/74 , C07D213/80 , C07D239/26 , C07D239/34 , C07D239/42 , C07D257/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/43 , A61K31/535 , A61K31/41
Abstract: Novel pyrimidine, pyridine, pyridazine, pyrazine and triazine compounds are provided of the formula (I). The compounds of the invention are useful for treating hypertension, edema, renal failure, congestive heart failure, psoriasis and glaucoma, and in the prevention and treatment of atherosclerosis or to treat gastrointestinal disorders associated with enhanced contractility and/or motility of intestinal smooth muscle or to treat contractile disorders of the uterus.
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公开(公告)号：AU8414291A
公开(公告)日：1992-02-18
申请号：AU8414291
申请日：1991-07-11
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , KERKMAN DANIEL J , BHATIA PRAMILA A , BASHA ANWER
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D333/36 , C07D307/66
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公开(公告)号：GR900100231A
公开(公告)日：1991-07-31
申请号：GR90100231
申请日：1990-03-28
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , KERKMAN DANIEL J , MARTIN JONATHAN G , STEWART O ADREW , SUMMERS B JAMES JR
IPC: C12N9/99 , A61K31/17 , A61K31/195 , A61K31/22 , A61K31/275 , A61K31/38 , A61K31/381 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C275/64 , C07C323/44 , C07C323/47 , C07C335/40 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/32 , C07D333/36 , C07D335/08 , C07D409/04 , C07D409/06 , C07D409/12 , C07D307/81
Abstract: ±ywUWu¿q€ð lºywvÐ wÐyVq¡Œ€Ðxw~q¿æz¿ÆtSuq€tæ€mqµuXsµwŒ€ðqݤXsµw€~qµ€¤æµæuXsµwŒ€tVq¡€~q¿ÆªwyVq¡€µzÞÐyZu€quqz¿wsS\u€¿Æ¡€•€~qµ€‘ «µxwvЪæu÷zÆ¡Œ€wµ€wxwVæ¡€æVuqµ€ÞyTzµtæ¡€zqu€wÐzVæ¡Œ€ªµq€¤æyqxæVæ¡€Ýsæªtwu\ºZu€~q¿qz¿÷zæ\u€qz¤æuæµZuŒ€xwЀSÞwÐu€zqu€qµ¿Vq€«æÐ~w¿yµSuµq€~qµ€÷ssq€xqy÷ª\ªq€¿Æ¡€ºyqz¿µ~W¿Æ¿w¡€¿\u€æu¸Xt\u€¿Æ¡€«µxwvЪæu÷zÆ¡ €€
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公开(公告)号：IE77040B1
公开(公告)日：1997-11-19
申请号：IE246991
申请日：1991-07-15
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , KERKMAN DANIEL J , BASHA ANWER , STEWART ANDREW O , BHATIA PRAMILA A , MARTIN JONATHAN G
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07C271/06 , C07C323/34
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公开(公告)号：GR3022120T3
公开(公告)日：1997-03-31
申请号：GR960403554
申请日：1996-12-20
Applicant: ABBOTT LAB
Inventor： BROOKS DEE W , STEWART ANDREW O , KERKMAN DANIEL J , BHATIA PRAMILA A , BASHA ANWER , MARTIN JONATHAN G
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D333/36 , C07D307/66
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