公开(公告)号：WO0220533A3

公开(公告)日：2002-08-22

申请号：PCT/US0126878

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： BASHA FATIMA Z ,  WENDT MICHAEL D ,  PRATT JOHN K

IPC: A61P13/00 ,  C07D519/00 ,  A61K31/5365

CPC classification number: C07D519/00

Abstract: The present invention relates to compounds having formula I and to pharmaceutically acceptable salts thereof. Compounds of formula I inhibit a1 adrenoreceptors and may be useful for treating benign prostatic hyperplasia (also called benign prostatic hypertrophy) and other urological diseases such as bladder outlet obstruction, neurogenic bladder and gynecological syndromes.

Abstract translation: 本发明涉及具有式I的化合物及其药学上可接受的盐。 式I的化合物抑制a1肾上腺素受体，并且可用于治疗良性前列腺增生（也称为良性前列腺肥大）和其它泌尿系统疾病，例如膀胱出口阻塞，神经源性膀胱和妇科综合征。

公开(公告)号：WO0024741A3

公开(公告)日：2000-07-13

申请号：PCT/US9925536

申请日：1999-10-28

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  AGRIOS KONSTANTINOS A ,  BASHA FATIMA Z ,  CHEN YIYUAN ,  KORT MICHAEL E ,  KYM PHILIP R ,  TANG RUI ,  TURNER SEAN C ,  YI LIN

IPC: C07D487/14 ,  A61K31/4355 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61P1/00 ,  A61P9/10 ,  A61P11/06 ,  A61P13/00 ,  A61P15/00 ,  A61P15/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P43/00 ,  C07D471/04 ,  C07D471/14 ,  C07D491/04 ,  C07D491/052 ,  C07D491/14 ,  C07D491/153 ,  C07D495/14 ,  A61K31/435 ,  A61K31/47 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract translation: 具有式（I）的化合物可用于治疗通过钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。

公开(公告)号：WO0183480A3

公开(公告)日：2002-07-18

申请号：PCT/US0114164

申请日：2001-05-02

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  AGRIOS KONSTANTINOS A ,  BASHA FATIMA Z ,  CHEN YIYUAN ,  KORT MICHAEL E ,  KYM PHILIP R ,  TANG RUI ,  TURNER SEAN C ,  YI LIN

IPC: A61K31/4355 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4741 ,  A61K31/4745 ,  A61P13/02 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P21/00 ,  C07C45/00 ,  C07C45/29 ,  C07C45/30 ,  C07C45/63 ,  C07C205/44 ,  C07D471/04 ,  C07D471/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/052 ,  C07D491/056 ,  C07D491/14 ,  C07D491/147 ,  C07D491/153 ,  C07D495/14 ,  A61K31/4353

CPC classification number: C07D471/04 ,  C07C45/00 ,  C07C45/298 ,  C07C45/30 ,  C07C45/63 ,  C07C205/44 ,  C07D471/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14 ,  C07C47/55

Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract translation: 具有式（I）的化合物可用于治疗由钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。

公开(公告)号：GR3034485T3

公开(公告)日：2000-12-29

申请号：GR20000402174

申请日：2000-09-26

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：AU705283B2

公开(公告)日：1999-05-20

申请号：AU4745796

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：AU4745796A

公开(公告)日：1996-08-14

申请号：AU4745796

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：AU647174B2

公开(公告)日：1994-03-17

申请号：AU8374491

申请日：1991-09-09

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  DE BISWANATH ,  ZYDOWSKY THOMAS M ,  KERKMAN DANIEL J ,  DEBERNARDIS JOHN F ,  ROSENBERG SAUL H ,  SHIOSAKI KAZUMI ,  BASHA FATIMA Z ,  TASKER ANDREW S ,  GELDERN THOMAS W VON ,  KESTER JEFFREY A ,  HOLLEMAN WILLIAM H

IPC: A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P1/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P27/02 ,  A61P43/00 ,  C07D213/64 ,  C07D213/70 ,  C07D213/71 ,  C07D213/72 ,  C07D213/74 ,  C07D213/80 ,  C07D239/26 ,  C07D239/34 ,  C07D239/42 ,  C07D257/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  A61K31/43 ,  A61K31/535 ,  A61K31/41

Abstract: Novel pyrimidine, pyridine, pyridazine, pyrazine and triazine compounds are provided of the formula (I). The compounds of the invention are useful for treating hypertension, edema, renal failure, congestive heart failure, psoriasis and glaucoma, and in the prevention and treatment of atherosclerosis or to treat gastrointestinal disorders associated with enhanced contractility and/or motility of intestinal smooth muscle or to treat contractile disorders of the uterus.

公开(公告)号：BR0012502A

公开(公告)日：2003-06-24

申请号：BR0012502

申请日：2000-12-15

Applicant: ABBOTT LAB

Inventor： BASHA FATIMA Z ,  HINMAN MIRA M ,  KOPECKA HANA A ,  SEARLE XENIA B ,  SOWIN THOMAS J ,  WODKA DARIUSZ ,  SUROWY CAROL ,  FALTYNEK CONNIE R

IPC: C07D295/08 ,  A61K31/17 ,  A61K31/35 ,  A61K31/357 ,  A61K31/397 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/453 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/541 ,  A61K31/55 ,  A61P11/06 ,  A61P43/00 ,  C07C275/32 ,  C07D207/06 ,  C07D207/12 ,  C07D211/46 ,  C07D235/26 ,  C07D239/10 ,  C07D241/08 ,  C07D265/30 ,  C07D295/096 ,  C07D295/10 ,  C07D295/18 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D309/04 ,  C07D309/08 ,  C07D309/10 ,  C07D309/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/113 ,  A61K31/41

公开(公告)号：GR3036560T3

公开(公告)日：2001-12-31

申请号：GR20010401414

申请日：2001-09-06

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  PRATT JOHN K ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  YAMAMOTO DIANE M

IPC: C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D487/02 ,  C07D495/02 ,  C07D487/00

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：CA2407317A1

公开(公告)日：2001-11-08

申请号：CA2407317

申请日：2001-05-02

Applicant: ABBOTT LAB

Inventor： YI LIN ,  TANG RUI ,  CARROLL WILLIAM A ,  KYM PHILIP R ,  TURNER SEAN C ,  CHEN YIYUAN ,  BASHA FATIMA Z ,  KORT MICHAEL E ,  AGRIOS KONSTANTINOS A

IPC: A61K31/4355 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4741 ,  A61K31/4745 ,  A61P13/02 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P21/00 ,  C07C45/00 ,  C07C45/29 ,  C07C45/30 ,  C07C45/63 ,  C07C205/44 ,  C07D471/04 ,  C07D471/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/052 ,  C07D491/056 ,  C07D491/14 ,  C07D491/147 ,  C07D491/153 ,  C07D495/14 ,  A61K31/4353 ,  C07D209/00 ,  C07D221/00 ,  C07D307/00 ,  C07D311/00 ,  C07D333/00

Abstract: Compounds having the formula (I) are useful in treating diseases prevented b y or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.