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1.发明申请PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS 审中-公开吡咯烷-3-羧酸衍生物及其作为内皮素拮抗剂的用途
公开(公告)号：WO9906397A3
公开(公告)日：1999-12-09
申请号：PCT/US9815479
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056
CPC classification number: C07D207/27 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：AU781355B2
公开(公告)日：2005-05-19
申请号：AU2984101
申请日：2001-03-23
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J JR , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K31/40 , C07D207/16 , C07D401/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59
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公开(公告)号：NZ502395A
公开(公告)日：2002-08-28
申请号：NZ50239598
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： KING STEVEN A , WITTENBERGER STEVEN J , WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056
Abstract: [2S,3R,4S]-2-(2,2-Dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-1 -(N,N-di-(n-butyl)-aminocarbonylmethyl)-pyrrolidine-3-carboxylic acid and [2S,3R,4S]-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-[(N-butyl-N- (4-dimethylaminobutyl)-amino)carbonylmethyl]-pyrrolidine-3-carboxylic acid, a pharmaceutically acceptable salt thereof and the pharmaceutical composition thereof are useful for antagonizing the endothelin activity.
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公开(公告)号：BR9707509A
公开(公告)日：1999-07-27
申请号：BR9707509
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , VON GELDERN THOMAS W , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：CZ9802537A3
公开(公告)日：1999-07-14
申请号：CZ253798
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , VON GELDERN THOMAS W , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J JR , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572 , A61K31/445 , C07D413/04
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
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Patent Agency Ranking
公开(公告)号：ZA986908B
公开(公告)日：1999-04-26
申请号：ZA986908
申请日：1998-07-31
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K20060101 , C07D20060101 , C07F20060101 , C07D , A61K , C07F
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公开(公告)号：AU8592198A
公开(公告)日：1999-02-22
申请号：AU8592198
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J JR , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056
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公开(公告)号：ZA9701179B
公开(公告)日：1998-01-15
申请号：ZA9701179
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY JR KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K20060101 , C07D20060101 , C07F20060101 , C07D , A61K , C07F
CPC classification number: Y02P20/55
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公开(公告)号：HU226888B1
公开(公告)日：2010-01-28
申请号：HU9901580
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： BOYD STEVEN A , HENRY KENNETH JR , HUTCHINS CHARLES W , JAE HWAN-SOO , KESTER JEFFREY A , KING STEVEN A , LIU GANG , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , TASKER ANDREW S , WINN MARTIN , WITTENBERGER STEVEN J , VON GELDERN THOMAS W
IPC: A61K31/40 , A61K31/4025 , A61K31/435 , A61K31/4439 , A61P9/00 , A61P35/00 , C07D207/04 , C07D207/16 , C07D211/06 , C07D401/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59
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10.发明专利
公开(公告)号：CZ296660B6
公开(公告)日：2006-05-17
申请号：CZ253798
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , VON GELDERN THOMAS W , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D405/04 , A61K31/34 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572
Abstract: Benzo-1,3-dioxolyl- a benzofuranyl-substituované pyrrolidinové deriváty vzorce I nebo jejich farmaceuticky prijatelné soli, farmaceutický prostredek a jejich pouzití k výrobe léciva pro antagonizaci endothelinu a lécbe hypertenze, mestnavého selhánísrdce, aterosklerózy, rakoviny prostaty, atd. Resení se také týká meziproduktu vzorce II.
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