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1.发明申请PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS 审中-公开吡咯烷-3-羧酸衍生物及其作为内皮素拮抗剂的用途
公开(公告)号：WO9906397A3
公开(公告)日：1999-12-09
申请号：PCT/US9815479
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056
CPC classification number: C07D207/27 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：WO0218321A3
公开(公告)日：2003-04-10
申请号：PCT/US0126133
申请日：2001-08-21
Applicant: ABBOTT LAB
Inventor： LIU GANG , LI YIHONG , JANOWICK DAVID A , PEI ZHONGHUA
IPC: A61P3/10 , C07C233/56 , C07C259/06 , C07D207/26 , C07D207/27 , C07D209/14 , C07D209/48 , C07D211/26 , C07D211/96 , C07D213/74 , C07D215/12 , C07D215/14 , C07D277/74 , C07D295/13 , C07D295/26 , C07D307/68 , C07D307/91 , C07D319/18 , C07D333/20 , C07D405/06 , A61K31/194 , C07D295/12 , C07D295/22
CPC classification number: C07D207/27 , C07C233/56 , C07C259/06 , C07C2601/08 , C07D209/14 , C07D209/48 , C07D211/26 , C07D211/96 , C07D213/74 , C07D215/12 , C07D215/14 , C07D277/74 , C07D295/13 , C07D295/26 , C07D307/68 , C07D307/91 , C07D319/18 , C07D333/20 , C07D405/06
Abstract: Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Abstract translation: 式（I）化合物或其治疗上可接受的盐是蛋白酪氨酸激酶PTP1B抑制剂。 公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。
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公开(公告)号：WO0218363A2
公开(公告)日：2002-03-07
申请号：PCT/US0126356
申请日：2001-08-23
Applicant: ABBOTT LAB
Inventor： LIU GANG , PEI ZHONG HUA
IPC: A61P3/06 , C07C59/68 , C07D307/91 , C07D317/00
CPC classification number: C07D307/91 , C07B2200/07 , C07C59/68
Abstract: Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Abstract translation: 式（I）化合物或其治疗上可接受的盐是蛋白酪氨酸激酶PTP1B抑制剂。 公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。
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4.发明申请PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF C-JUN N-TERMINAL KINASES 审中-公开吡啶衍生物作为C-JUN N-TERMINAL KINASES的抑制剂有用
公开(公告)号：WO2006083673A3
公开(公告)日：2006-12-21
申请号：PCT/US2006002789
申请日：2006-01-24
Applicant: ABBOTT LAB , LIU GANG , SHAM HING L , SZCZEPANKIEWICZ BRUCE G , XIN ZHILI , ZHAO HONGYU , SERBY MICHAEL D , LIU BO , LIU MEI
Inventor： LIU GANG , SHAM HING L , SZCZEPANKIEWICZ BRUCE G , XIN ZHILI , ZHAO HONGYU , SERBY MICHAEL D , LIU BO , LIU MEI
IPC: C07D213/85 , A61K31/44 , A61P3/00 , A61P19/00 , A61P25/00 , C07D213/73 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/12
CPC classification number: C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
Abstract: The present invention relates to compounds of formula (I), that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
Abstract translation: 本发明涉及式（I）化合物，其为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂，含有该化合物的组合物和该化合物在 预防或治疗由JNK1，JNK2和JNK3激活调节的疾病。
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公开(公告)号：WO0218323A3
公开(公告)日：2002-06-27
申请号：PCT/US0126906
申请日：2001-08-29
Applicant: ABBOTT LAB
Inventor： LIU GANG , SZCZEPANKIEWICZ BRUCE G , PEI ZHONGHUA , XIN ZHILI , OOST THORSTEN K , JANOWICK DAVID A
IPC: A61P3/10 , C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18 , A61K31/357 , A61K31/404 , A61K31/535 , C07D209/30 , C07D239/04 , C07D319/10
CPC classification number: C07D295/185 , C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D319/18
Abstract: Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Abstract translation: 式（I）化合物或其治疗上可接受的盐是蛋白酪氨酸激酶PTP1B抑制剂。 公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO0039081A3
公开(公告)日：2001-05-25
申请号：PCT/US9931162
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , XIN ZHILI , BOYD STEVEN A , JAE HWAN-SOO , LYNCH JOHN K , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A
IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/10 , A61K31/33 , C07D295/20
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Abstract translation: 本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。
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公开(公告)号：HU226888B1
公开(公告)日：2010-01-28
申请号：HU9901580
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： BOYD STEVEN A , HENRY KENNETH JR , HUTCHINS CHARLES W , JAE HWAN-SOO , KESTER JEFFREY A , KING STEVEN A , LIU GANG , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , TASKER ANDREW S , WINN MARTIN , WITTENBERGER STEVEN J , VON GELDERN THOMAS W
IPC: A61K31/40 , A61K31/4025 , A61K31/435 , A61K31/4439 , A61P9/00 , A61P35/00 , C07D207/04 , C07D207/16 , C07D211/06 , C07D401/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59
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公开(公告)号：MX2009011753A
公开(公告)日：2009-12-01
申请号：MX2009011753
申请日：2008-04-30
Applicant: ABBOTT LAB
Inventor： SOUERS ANDREW J , KYM PHILIP R , LIU GANG , XIN ZHILI
IPC: C07D487/04 , A61K31/519 , A61P3/04 , A61P3/10
Abstract: La presente invención se refiere a compuestos de la fórmula (I): en donde R1, R2 y R3, son como aquí se definen. También se describen composiciones farmacéuticas y métodos para el tratamiento de enfermedades o padecimientos relacionados con la enzima DGAT-1.
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公开(公告)号：EA009052B1
公开(公告)日：2007-10-26
申请号：EA200401528
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TON , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D211/62 , C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: Настоящееизобретениеотноситсяк новымпроизводнымдиарилсульфидовформулы (I), вкоторыхпокрайнеймереодиниз R-Rпредставляет "цис-циннамид" (а) или "транс-циннамид" (b), адругиерадикалыопределеныв формулеизобретенияи которыемогутбытьиспользованыдлялечениявоспалительныхи иммунныхзаболеваний; кспособамполучениязаявленныхсоединенийи промежуточнымсоединениям, используемымв указанныхспособах.
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公开(公告)号：BG65177B1
公开(公告)日：2007-05-31
申请号：BG10573201
申请日：2001-07-25
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , XIN ZHILI , BOYD STEVEN , JAE HWAN-SOO , LYNCH JOHN , ZHU GUI-DONG , FREEMAN JENNIFER , GUNAWARDANA INDRANI , STAEGER MICHAEL
IPC: C07C323/62 , C07D295/12 , A61K31/10 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/30 , C07D209/38 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D311/22 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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