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公开(公告)号：DK1278747T3
公开(公告)日：2007-01-02
申请号：DK01935065
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , ALTENBACH ROBERT J , AGRIOS KONSTANTINOS A , DRIZIN IRENE , KORT MICHAEL J
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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Patent Agency Ranking
公开(公告)号：CA2407838C
公开(公告)日：2010-01-12
申请号：CA2407838
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , KORT MICHAEL J , ALTENBACH ROBERT J , CARROLL WILLIAM A , AGRIOS KONSTANTINOS A
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxi ng smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：ES2269400T3
公开(公告)日：2007-04-01
申请号：ES01935065
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , ALTENBACH ROBERT J , DRIZIN IRENE , KORT MICHAEL J
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: Un compuesto que tiene la fórmula I: o una sal del mismo farmacéuticamente aceptable, en la cual n es 0-1; m es 1-2; A es seleccionado del grupo que consta de NR2, O y S; A'' es seleccionado del grupo que consta de NR3, O, S y CR4R5; D es C(O); D'' es C(O); R1 es seleccionado del grupo que consta de arilo y heterociclo; R2 y R3 son seleccionados independientemente del grupo que consta de hidrógeno, alcoxialquilo, alquilo, arilalquilo, cicloalquilo, cicloalquilalquilo, haloal- quilo, heterocicloalquilo, hidroxi, hidroxialquilo, -NZ1Z2 y (NZ1Z2)alquilo, donde Z1 y Z2 son seleccionados independientemente del grupo que consta de hidrógeno, alquilo, alquilcarbonilo, arilo, arilalquilo y formilo; R4 y R5 son seleccionados independientemente del grupo que consta de hidrógeno y alquilo; o R4 y R5 junto con el átomo de carbono al que están uni- dos forman un anillo carbocíclico de 3-6 miembros; R6 es alquilo; R7 es seleccionado del grupo que consta de hidrógeno y alquilo; R8 es alquilo y R9 es seleccionado del grupo que consta de hidrógeno y alquilo.
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公开(公告)号：PT1278747E
公开(公告)日：2007-01-31
申请号：PT01935065
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , ROBERT J ALTENBACH , KORT MICHAEL J
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
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公开(公告)号：AT337319T
公开(公告)日：2006-09-15
申请号：AT01935065
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , ALTENBACH ROBERT J , DRIZIN IRENE , KORT MICHAEL J
IPC: C07D335/02 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D471/14 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00 , A61K31/4745
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：CA2407838A1
公开(公告)日：2001-11-08
申请号：CA2407838
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , KORT MICHAEL J , ALTENBACH ROBERT J , DRIZIN IRENE , AGRIOS KONSTANTINOS A
IPC: C07D335/02 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D471/14 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00 , A61K31/4745
Abstract: The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxi ng smooth muscle cells, and inhibiting bladder contractions.
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