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公开(公告)号：JP2011063594A
公开(公告)日：2011-03-31
申请号：JP2010235798
申请日：2010-10-20
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , SHARMA PADAM N , BENNANI YOUSSEF L , CURTIS MICHAEL P
IPC: C07C255/58 , A61P3/00 , A61P25/00 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/092 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
CPC classification number: C07C255/58 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide pharmaceutical compositions useful in treating conditions or disorders which are prevented or ameliorated by histamine-3 receptor ligands, a method of using such compounds and compositions, and a preparation process therefor.
SOLUTION: There are provided a compound of formula (I), pharmaceutically acceptable salts, esters, amides or prodrugs thereof. Pharmaceutical compositions, usage and preparation process therefor are also provided. In the formula, each symbol is defined specifically.
COPYRIGHT: (C)2011,JPO&INPITAbstract translation: 待解决的问题：提供可用于治疗由组胺-3受体配体预防或改善的病症或病症的药物组合物，使用这些化合物和组合物的方法及其制备方法。 解决方案：提供式（I）的化合物，其药学上可接受的盐，酯，酰胺或前药。 还提供了药物组合物，用途和制备方法。 在公式中，每个符号都被具体定义。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：WO0109096A3
公开(公告)日：2001-08-16
申请号：PCT/US0021054
申请日：2000-08-02
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: C07D249/18 , A61K31/166 , A61K31/17 , A61K31/417 , A61K31/4192 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C275/54 , C07C279/22 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/26 , C07D209/08 , C07D213/74 , C07D213/75 , C07D215/38 , C07D233/02 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12 , C07D407/12 , A61K31/155 , C07C279/30
CPC classification number: C07D213/74 , A61K31/17 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D215/38 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12
Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗钾通道开放剂所预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中打开钾通道的方法。
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公开(公告)号：WO2008060766A3
公开(公告)日：2009-02-19
申请号：PCT/US2007080132
申请日：2007-10-02
Applicant: ABBOTT LAB , COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
Inventor： COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC: A61K31/417 , A61K31/496 , A61K31/506 , A61K45/06 , A61P29/00
CPC classification number: A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
Abstract: This invention discloses histamine H4 receptor ligands for use in a method of treating pain
Abstract translation: 本发明公开了用于治疗疼痛的方法中的组胺H 4受体配体
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4.发明申请TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS 审中-公开三聚二氢吡咯烷酮和三羟基二硅氧烷钾通道开路器
公开(公告)号：WO0166544A3
公开(公告)日：2002-01-03
申请号：PCT/US0106952
申请日：2001-03-02
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , ALTENBACH ROBERT J , CARROLL WILLIAM A
IPC: C07D491/147 , A61K31/437 , A61P1/00 , A61P7/12 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/08 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P43/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/04 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14 , A61K31/4353 , A61P13/00 , C07D491/04
CPC classification number: C07D471/04 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D491/14 , C07D495/14 , C07C47/55
Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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公开(公告)号：WO2008060767A2
公开(公告)日：2008-05-22
申请号：PCT/US2007080133
申请日：2007-10-02
Applicant: ABBOTT LAB , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
Inventor： ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC: C07D491/04 , C07D493/04 , C07H17/04
CPC classification number: C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
Abstract translation: 本文描述了大环苯并稠合的嘧啶化合物，包含此类化合物的组合物，制备所述化合物的方法以及使用此类化合物和组合物治疗和预防疾病，病症和障碍进展的方法。
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Patent Agency Ranking
公开(公告)号：WO0007997A8
公开(公告)日：2000-05-04
申请号：PCT/US9917739
申请日：1999-08-06
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , MEYER MICHAEL D , KERWIN JAMES F JR , HOLLADAY MARK W , KHILEVICH ALBERT , KOLASA TEODOZYJ , ROHDE JEFFREY , CARROLL WILLIAM A
IPC: C07D233/64 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/426 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61P13/02 , A61P15/00 , A61P25/02 , A61P43/00 , C07D233/38 , C07D233/54 , C07D233/61 , C07D233/66 , C07D233/84 , C07D263/32 , C07D263/48 , C07D277/20 , C07D277/28 , C07D277/40 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12
CPC classification number: C07D233/64 , C07D233/84 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/12 , C07D417/12
Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with alpha 1A agonists. Also disclosed are alpha 1A agonist compositions and a method of activating alpha 1 adrenoceptors in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗α1A激动剂所预防或改善的疾病。 还公开了α1A激动剂组合物和激活哺乳动物中α1肾上腺素能受体的方法。
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7.发明申请
公开(公告)号：WO2005113536A3
公开(公告)日：2006-03-30
申请号：PCT/US2005014866
申请日：2005-04-29
Applicant: ABBOTT LAB , ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , CURTIS MICHAEL P
Inventor： ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , CURTIS MICHAEL P
IPC: C07D401/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/02 , C07D471/04 , C07D487/04 , C07D491/02 , C07D491/04 , C07D495/04 , C07D498/02 , C07D513/04 , A61K31/4709 , A61K31/4725
CPC classification number: C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds of formula (I) wherein R
Abstract translation: 式（I）的化合物，其中R 1，
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公开(公告)号：WO02062762A3
公开(公告)日：2003-07-31
申请号：PCT/US0205252
申请日：2002-01-17
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: A61K31/17 , A61K31/275 , A61K31/4164 , A61K31/4406 , A61K31/455 , A61K31/47 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/10 , A61P17/00 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07C233/36 , C07C233/78 , C07C233/83 , C07C255/61 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/20 , C07D209/08 , C07D209/30 , C07D213/40 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
CPC classification number: C07D213/40 , A61K31/17 , A61K31/275 , A61K31/4406 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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公开(公告)号：CA2407838C
公开(公告)日：2010-01-12
申请号：CA2407838
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , KORT MICHAEL J , ALTENBACH ROBERT J , CARROLL WILLIAM A , AGRIOS KONSTANTINOS A
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxi ng smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：DE60036476T2
公开(公告)日：2008-06-12
申请号：DE60036476
申请日：2000-08-02
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: C07D213/74 , C07D249/18 , A61K31/166 , A61K31/17 , A61K31/417 , A61K31/4192 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C275/54 , C07C279/22 , C07C279/28 , C07C279/30 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/26 , C07D209/08 , C07D213/75 , C07D215/38 , C07D233/02 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12 , C07D407/12
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