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    Quinolizinone type compounds
    2.
    发明专利
    Quinolizinone type compounds 未知

    公开(公告)号：AU689809B2

    公开(公告)日：1998-04-09

    申请号：AU7925894

    申请日：1994-09-30

    Applicant: ABBOTT LAB

    Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

    IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

    Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

    3.
    发明专利
    未知

    公开(公告)号：BR9407806A

    公开(公告)日：1997-08-19

    申请号：BR9407806

    申请日：1994-09-30

    Applicant: ABBOTT LAB

    Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

    IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

    Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

    QUINOLIZINONE TYPE COMPOUNDS
    7.
    发明专利
    QUINOLIZINONE TYPE COMPOUNDS 未知

    公开(公告)号：CA2081891C

    公开(公告)日：1999-03-16

    申请号：CA2081891

    申请日：1991-05-01

    Applicant: ABBOTT LAB

    Inventor： CHU DANIEL T ,  LEE CHEUK M ,  LI QUN ,  COOPER CURT S ,  PLATTNER JACOB J

    IPC: A61K31/435 ,  A61K31/47 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/10 ,  C07D491/16 ,  C07D495/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/495 ,  A61K38/04 ,  C07K5/04 ,  C07K7/06

    Abstract: Novel compounds are disclosed having formula (I) as well as pharmaceutically acc eptable salts, esters and amides thereof, wherein R1 is selected from (a) loweralkyl, (b) loweralkenyl, (c) halo(loweralky l), (d) loweralkoxy, (e) cycloalkyl of from 3 to 8 carbons (f) phenyl, (g) halo, (h) cyano, (i) nitro, (j) bicycloalkyl, (k) lowe ralkynyl, (l) alkoxycarbonyl, (m) nitrogen-containing aromatic heterocycle and (n) a group of the formula -NR7R8; R2 is selected from the group containing of halogen, loweralkoxy, carbocyclic aryloxy or carbocyclic aryl(loweralkyl)oxy, loweralkyl, loweralkenyl, cycloalkyl of from 3 to 8 carbons, cycloalkenyl of from 4 to 8 carbons, carbocyclic aryl(loweralkyl), cycl oalkyl(loweralkyl), phenyl, amino, (loweralkyl)amino, carbocyclic aryl(loweralkyl)amino, hydroxy-substituted (loweralkyl)amino, nitrog en-containing aromatic heterocycle, bicyclic nitrogen-containing heterocycle and nitrogen-containing heterocycle hav ing formula (II), wherein x is 0 to 3; R9 is selected from (a)-(CH2)m-, wherein m is 1, 2 or 3, and (b) -(CH2)n R10(CH, )p-, wherein R10 is selected from S, O and N, n is 1 or 2, and p is 1 or 2: and Y is a non-hydrogen substituent independently selected from loweralkyl, halo(loweralkyl), loweralkoxy, hydroxy-substituted loweralkyl, hydroxy, amino(loweralkyl), halogen and a group having the formula -NR11R12; R3 is hydrogen, halogen or loweralkoxy; R4 is selected from the group consisting of hydrogen loweralkyl, a pharmaceutically acceptable cation and a prodrug ester group: R5 is selected fro m the group consisting of hydrogen halogen, hydroxy, loweralkyl, halo(loweralkyl), loweralkoxy and a group having the formul a -NR13R14; and A is N or CR6, wherein R6 is selected from hydrogen, halogen, loweralkyl. halo(loweralkyl), hyd roxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy and amino(loweralkyl) or, alternatively, R 1 and R6, taken together with the atoms to which they are attached form a 6-membered saturated ring which may contain an oxygen o r a sulfur atom and which may be substituted with loweralkyl; with the proviso that when R5 is hydrogen and A is CH then either (a) R1 is NR7R8, or (b) R2 is a group having formula (III), wherein x is 1-3 and R9 and Y are as defined above.

    5H-(1)BENZOPYRANO(3,4-D)PYRIDINES
    9.
    发明专利
    5H-(1)BENZOPYRANO(3,4-D)PYRIDINES 未知

    公开(公告)号：CA1037955A

    公开(公告)日：1978-09-05

    申请号：CA203794

    申请日：1974-07-02

    Applicant: ABBOTT LAB

    Inventor： LEE CHEUK M

    IPC: A61K31/435 ,  A61K31/445 ,  A61P25/04 ,  C07C37/055 ,  C07C39/367 ,  C07D491/04 ,  C07D491/052

    Abstract: 5H-1!BENZOPYRANO3,4-d!PYRIDINES 5H-1!Benzopyrano3,4-d!pyridines represented by the formula wherein each R1 is loweralkyl, R2 is alkyl, cycloalkyl or wherein Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms and each R4, R5 and R6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and R3 is hydroxy, acyloxy, loweralkoxy, loweralkenyloxy, loweralkynyloxy or X is a straight or branched chain alkylene group having from one to eight carbon atoms, and wherein R7 and R8 are the same or different members of the group consisting of hydrogen or loweralkyl, or wherein X is a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH2, O, S or NR10 with R10 being hydrogen or loweralkyl, with the limitation that when Z is O or S, the sum of a and b is 3 or 4; and when Z is NR10 , the sum of a and b is 3-5; R9 is hydrogen or loweralkyl, and the pharmaceutically acceptable salts thereof.

    10.
    发明专利
    未知

    公开(公告)号：AT217309T

    公开(公告)日：2002-05-15

    申请号：AT94929998

    申请日：1994-09-30

    Applicant: ABBOTT LAB

    Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

    IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

    Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

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