公开(公告)号：JPS62169753A

公开(公告)日：1987-07-25

申请号：JP2427186

申请日：1986-02-07

Applicant: ABBOTT LAB

Inventor： LULY JAY RICHARD ,  PLATTNER JOHN JACOB ,  ROSENBERG SAUL HOWARD ,  FUNG ANTHONY K L

IPC: C07K14/81 ,  A61K31/16 ,  A61K31/165 ,  A61K31/18 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/27 ,  A61K31/33 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/655 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C231/00 ,  C07C237/08 ,  C07C237/10 ,  C07C237/22 ,  C07C239/00 ,  C07C253/00 ,  C07C255/24 ,  C07C269/00 ,  C07C273/10 ,  C07C301/00 ,  C07C309/63 ,  C07C311/00 ,  C07C313/00 ,  C07C317/28 ,  C07C323/41 ,  C07C323/60 ,  C07D231/12 ,  C07D233/64 ,  C07D263/22 ,  C07D295/18 ,  C07D521/00 ,  C07K5/06 ,  C12N9/99

公开(公告)号：EP0295294A4

公开(公告)日：1990-04-10

申请号：EP88900918

申请日：1987-12-22

Applicant: ABBOTT LAB ,  FUNG ANTHONY K L ,  KEMPF DALE JOHN ,  LULY JAY RICHARD ,  ROSENBERG SAUL HOWARD ,  PLATTNER JACOB JOHN

Inventor： FUNG ANTHONY K L ,  KEMPF DALE JOHN ,  LULY JAY RICHARD ,  ROSENBERG SAUL HOWARD ,  PLATTNER JACOB JOHN

IPC: C12N9/99 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4406 ,  A61K38/00 ,  A61P9/12 ,  C07C67/00 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C235/34 ,  C07C235/74 ,  C07C235/78 ,  C07C237/06 ,  C07C237/08 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/00 ,  C07C271/20 ,  C07C271/24 ,  C07C313/00 ,  C07C317/44 ,  C07C323/60 ,  C07C325/00 ,  C07C327/20 ,  C07C333/02 ,  C07D213/00 ,  C07D213/71 ,  C07D213/78 ,  C07D233/54 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/083 ,  C07K5/097 ,  C07K14/81

CPC classification number: C07D233/64 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0227 ,  C07K5/06026 ,  C07K5/06078 ,  C07K5/0802 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0821 ,  C07K5/0823

公开(公告)号：AT217309T

公开(公告)日：2002-05-15

申请号：AT94929998

申请日：1994-09-30

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

公开(公告)号：AT177420T

公开(公告)日：1999-03-15

申请号：AT94931987

申请日：1994-10-20

Applicant: ABBOTT LAB

Inventor： BAKER WILLIAM R ,  ROCKWAY TODD W ,  DONNER B GREGORY ,  SHEN WANG ,  ROSENBERG SAUL H ,  FAKHOURY STEPHEN A ,  O'CONNOR STEPHEN J ,  STOUT DAVID M ,  FUNG ANTHONY K L ,  GARVEY DAVID S ,  PRASAD RAJNANDAN ,  SULLIVAN GERARD M

IPC: C12N9/99 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61P3/06 ,  A61P7/00 ,  A61P9/10 ,  A61P31/04 ,  A61P43/00 ,  C07C69/52 ,  C07C69/74 ,  C07C231/02 ,  C07C233/19 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C233/61 ,  C07C233/62 ,  C07C233/63 ,  C07C235/36 ,  C07C235/40 ,  C07C237/24 ,  C07C245/14 ,  C07C251/42 ,  C07C259/08 ,  C07C275/26 ,  C07C311/51 ,  C07C323/40 ,  C07C323/46 ,  C07C327/20 ,  C07C327/36 ,  C07C327/38 ,  C07D207/325 ,  C07D213/40 ,  C07D257/04 ,  C07D257/06 ,  C07D263/24 ,  C07D271/06 ,  C07D271/10 ,  C07D277/20 ,  C07D277/34 ,  C07D285/16 ,  C07D285/18 ,  C07D307/42 ,  C07D307/52 ,  C07D309/32 ,  C07D317/60 ,  C07D319/06 ,  C07D333/08 ,  C07D333/58 ,  A61K31/16

公开(公告)号：AU7925894A

公开(公告)日：1995-05-04

申请号：AU7925894

申请日：1994-09-30

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

公开(公告)号：AU653959B2

公开(公告)日：1994-10-20

申请号：AU8531591

申请日：1991-08-02

Applicant: ABBOTT LAB

Inventor： BAKER WILLIAM R ,  BOYD STEVEN A ,  FUNG ANTHONY K L ,  STEIN HERMAN H ,  DENISSEN JON F ,  HUTCHINS CHARLES W ,  ROSENBERG SAUL H

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61P9/12 ,  A61P43/00 ,  C07D211/46 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D451/06 ,  C07D451/14 ,  C07D498/08

公开(公告)号：DK59991A

公开(公告)日：1991-04-04

申请号：DK59991

申请日：1991-04-04

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  BAKER WILLIAM R ,  BOYD STEVEN A ,  KEMPF DALE J ,  ARMIGER YOEK-LIN ,  ROSENBERG SAUL H ,  DE BISWANATH ,  PLATTNER JACOB J ,  SHAM HING LEUNG ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07C237/20 ,  C07D205/04 ,  C07D233/64 ,  C07D295/182 ,  C07D405/12 ,  C07K5/06

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

公开(公告)号：DK483488A

公开(公告)日：1988-08-30

申请号：DK483488

申请日：1988-08-30

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  KEMPF JOHN DALE ,  LULY JAY RICHARD ,  ROSENBERG SAUL HOWARD ,  PLATTNER JACOB JOHN

IPC: C12N9/99 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4406 ,  A61K38/00 ,  A61P9/12 ,  C07C67/00 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C235/34 ,  C07C235/74 ,  C07C235/78 ,  C07C237/06 ,  C07C237/08 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/00 ,  C07C271/20 ,  C07C271/24 ,  C07C313/00 ,  C07C317/44 ,  C07C323/60 ,  C07C325/00 ,  C07C327/20 ,  C07C333/02 ,  C07D213/00 ,  C07D213/71 ,  C07D213/78 ,  C07D233/54 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/083 ,  C07K5/097 ,  C07K14/81 ,  C07K5/04

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, (alpha,alpha)-dimethylbenzyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R2 is hydrogen or loweralkyl; R3 is loweralkenyl, [(alkoxy)alkoxy]alkyl, (thioalkoxy)alkyl, lowerakenyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is vinyl, formyl, hydroxymethyl or hydrogen; R7 is hydrogen or loweralkyl; R8 and R9 are independently selected from OH and NH2; and R6 is hydrogen, loweralkyl, vinyl or arylalkyl; provided that when R5 and R7 are both hydrogen and R8 and R9 are OH, the carbon bearing R5 is of the "R" configuration and the carbon bearing R6 is of the "S" configuration, or pharmaceutically acceptable salts or esters thereof. Also disclosed are renin inhibiting compositions, a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.

公开(公告)号：DK0677039T3

公开(公告)日：1999-09-27

申请号：DK94931987

申请日：1994-10-20

Applicant: ABBOTT LAB

Inventor： BAKER WILLIAM R ,  DONNER B GREGORY ,  FAKHOURY STEPHEN A ,  FUNG ANTHONY K L ,  GARVEY DAVID S ,  O'CONNOR STEPHEN J ,  PRASAD RAJNANDAN ,  ROCKWAY TODD W ,  ROSENBERG SAUL H ,  SHEN WANG ,  STOUT DAVID M ,  SULLIVAN GERARD M

IPC: C12N9/99 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61P3/06 ,  A61P7/00 ,  A61P9/10 ,  A61P31/04 ,  A61P43/00 ,  C07C69/52 ,  C07C69/74 ,  C07C231/02 ,  C07C233/19 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C233/61 ,  C07C233/62 ,  C07C233/63 ,  C07C235/36 ,  C07C235/40 ,  C07C237/24 ,  C07C245/14 ,  C07C251/42 ,  C07C259/08 ,  C07C275/26 ,  C07C311/51 ,  C07C323/40 ,  C07C323/46 ,  C07C327/20 ,  C07C327/36 ,  C07C327/38 ,  C07D207/325 ,  C07D213/40 ,  C07D257/04 ,  C07D257/06 ,  C07D263/24 ,  C07D271/06 ,  C07D271/10 ,  C07D277/20 ,  C07D277/34 ,  C07D285/16 ,  C07D285/18 ,  C07D307/42 ,  C07D307/52 ,  C07D309/32 ,  C07D317/60 ,  C07D319/06 ,  C07D333/08 ,  C07D333/58 ,  A61K31/16

公开(公告)号：AU689809B2

公开(公告)日：1998-04-09

申请号：AU7925894

申请日：1994-09-30

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.