公开(公告)号：NZ233795A

公开(公告)日：1992-07-28

申请号：NZ23379590

申请日：1990-05-24

Applicant: ABBOTT LAB

Inventor： LUCAS SCOTT D ,  ROCKWAY TODD W ,  DAVIDSEN STEVEN K ,  THOMAS A MITCHELL ,  VON GELDERN THOMAS W

IPC: A61K38/00 ,  A61K38/22 ,  A61P7/10 ,  A61P9/12 ,  C07K7/08 ,  C07K14/575 ,  C07K14/58 ,  C07K7/06 ,  A61K37/02 ,  A61K37/24

Abstract: The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R is a sulfur-containing group; R is a hydrophobic amino acid or dipeptide; R is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R is a hydrophobic amino acid; R is a peptide of up to three amino acids; R is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R is a sulfur-containing group.

公开(公告)号：GR900100396A

公开(公告)日：1991-10-10

申请号：GR90100396

申请日：1990-05-23

Applicant: ABBOTT LAB

Inventor： LUCAS SCOTT D ,  DAVIDSON STEVEN K ,  GELDERN VON THOMAS W ,  ROCKWAY TODD W ,  THOMAS MITCHELL A

IPC: A61K38/00 ,  A61K38/22 ,  A61P7/10 ,  A61P9/12 ,  C07K7/08 ,  C07K14/575 ,  C07K14/58 ,  A61K37/02 ,  A61K37/24

Abstract: The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R is a sulfur-containing group; R is a hydrophobic amino acid or dipeptide; R is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R is a hydrophobic amino acid; R is a peptide of up to three amino acids; R is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R is a sulfur-containing group.

公开(公告)号：AU5827690A

公开(公告)日：1990-12-18

申请号：AU5827690

申请日：1990-05-23

Applicant: ABBOTT LAB

Inventor： LUCAS SCOTT D ,  ROCKWAY TODD W ,  DAVIDSEN STEVEN K ,  THOMAS A MITCHELL ,  GELDERN THOMAS W VON

IPC: A61K38/00 ,  A61K38/22 ,  A61P7/10 ,  A61P9/12 ,  C07K7/08 ,  C07K14/575 ,  C07K14/58 ,  A61K37/02 ,  A61K37/24

Abstract: The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R is a sulfur-containing group; R is a hydrophobic amino acid or dipeptide; R is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R is a hydrophobic amino acid; R is a peptide of up to three amino acids; R is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R is a sulfur-containing group.

公开(公告)号：CA2033198A1

公开(公告)日：1990-11-25

申请号：CA2033198

申请日：1990-05-23

Applicant: ABBOTT LAB

Inventor： LUCAS SCOTT D ,  ROCKWAY TODD W ,  DAVIDSEN STEVEN K ,  THOMAS MITCHELL A ,  VON GELDERN THOMAS

IPC: A61K38/00 ,  A61K38/22 ,  A61P7/10 ,  A61P9/12 ,  C07K7/08 ,  C07K14/575 ,  C07K14/58 ,  A61K38/10

Abstract: Novel atrial peptides of the formula are disclosed which have useful hypotensive, natriuretic and diuretic activity and in which R1 is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R2 is a sulfur-containing group; R3 is a hydrophobic amino acid or dipeptide; R4 is a dipeptide spacer, or a tripeptide containing a dipeptide spacer plus a basic amino acid residue; R5 is a hydrophobic amino acid; R6 is a peptide of up to three amino acids; R7 is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe?Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R8 is a sulfur-containing group, as well as pharmaceutically acceptable salts, esters and amides thereof.