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公开(公告)号：JP2013049681A
公开(公告)日：2013-03-14
申请号：JP2012225875
申请日：2012-10-11
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： WAGNER ROLF , TUFANO MICHAEL D , STEWART KENT D , ROCKWAY TODD W , RANDOLPH JOHN T , PRATT JOHN K , MOTTER CHRISTOPHER E , MARING CLARENCE J , LONGENECKER KENTON L , LIU YAYA , LIU DACHUN , KRUEGER ALLAN C , KATI WARREN M , HUTCHINSON DOUGLAS K , HUANG PEGGY P , FLENTGE CHARLES A , DONNER PAMELA L , DEGOEY DAVID A , BETEBENNER DAVID A , BARNES DAVID M , CHEN SHUANG , FRANCZYK II THADDEUS S , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , HENRY RODGER F , KOTECKI BRIAN J , LOU XIAOCHUN , SARRIS KATHY , ZHANG GEOFF G Z
IPC: C07D239/22 , A61K31/513 , A61K31/5377 , A61P1/16 , A61P31/14 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/14
CPC classification number: A61K31/513 , A61K31/5377 , C07D239/22 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/14
Abstract: PROBLEM TO BE SOLVED: To provide compounds useful to treat hepatitis C (HCV) infections.SOLUTION: In the compounds, the uracil or thymine derivative are linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t-butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1(2H)-yl)2-methoxy-styryl-phenyl)methanesulfonamide.
Abstract translation: 待解决的问题：提供可用于治疗丙型肝炎（HCV）感染的化合物。 解决方案：在化合物中，尿嘧啶或胸腺嘧啶衍生物通过亚苯连接成稠合的2-环环系（R6），或者通过另外的两个原子连接基（L）连接到5-6元单环（R6 ）。 应用进一步公开了两种特定化合物的多晶型物和假多晶型物：N-（6（3-叔丁基-5-（2,4-二氧代-3,4-二氢嘧啶-1（2H） - 基）2-甲氧基 - 苯基） 萘-2-基）甲磺酰胺和（E）-N-（4（3-叔丁基-5-（2,4-二氧代-3）4-二氢嘧啶-1（2H） - 基）2-甲氧基苯乙烯基 苯基）甲磺酰胺。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：JP2013056886A
公开(公告)日：2013-03-28
申请号：JP2012221886
申请日：2012-10-04
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： FLENTGE CHARLES A , HUTCHINSON DOUGLAS K , BETEBENNER DAVID A , DEGOEY DAVID A , DONNER PAMELA L , KATI WARREN M , KRUEGER ALLAN C , LIU DACHUN , LIU YAYA , LONGENECKER KENTON L , MARING CLARENCE J , MOTTER CHRISTOPHER E , PRATT JOHN K , RANDOLPH JOHN T , ROCKWAY TODD W , STEWART KENT D , WAGNER ROLF , BARNES DAVID M , CHEN SHUANG , FRANCZYK II THADDEUS S , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , KOTECKI BRIAN J , LOU XIAOCHUN , ZHANG GEOFF G Z
IPC: C07D239/22 , A61K31/506 , A61K31/513 , A61K45/00 , A61P31/14 , A61P43/00 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/14
CPC classification number: C07D239/54 , A61K31/513 , A61K45/06 , C07D239/22 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K2300/00
Abstract: PROBLEM TO BE SOLVED: To provide anti-infective agents and the like, used either in combination with or in lieu of an interferon agent and/or ribavirin.SOLUTION: This invention relates to: (a) compounds and salts thereof that inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
Abstract translation: 要解决的问题：提供与干扰素和/或利巴韦林组合或代替干扰素剂和/或利巴韦林使用的抗感染剂等。 本发明涉及：（a）抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：WO2007081517A3
公开(公告)日：2007-12-21
申请号：PCT/US2006048685
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D495/04 , C07D471/04 , C07D513/04
CPC classification number: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：WO9905096A3
公开(公告)日：1999-06-03
申请号：PCT/US9815386
申请日：1998-07-24
Applicant: ABBOTT LAB
Inventor： GEYER ANDREW G , MCCLELLAN WILLIAM J , ROCKWAY TODD W , STEWART KENT D , WEITZBERG MOSHE , WENDT MICHAEL D
IPC: C07D295/08 , A61K31/155 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/47 , A61K31/472 , A61K31/505 , A61K31/5375 , A61P15/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C257/18 , C07C259/18 , C07C271/22 , C07C271/30 , C07C271/66 , C07C275/40 , C07C275/42 , C07C275/64 , C07C311/13 , C07C311/15 , C07C311/16 , C07C311/47 , C07C323/56 , C07C323/62 , C07D207/08 , C07D207/337 , C07D209/08 , C07D213/56 , C07D213/58 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/02 , C07D231/12 , C07D231/40 , C07D231/56 , C07D237/20 , C07D239/28 , C07D239/34 , C07D239/42 , C07D239/54 , C07D239/545 , C07D241/18 , C07D241/20 , C07D261/08 , C07D261/14 , C07D263/32 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/42 , C07D277/44 , C07D295/092 , C07D303/46 , C07D307/16 , C07D307/18 , C07D307/54 , C07D307/64 , C07D317/58 , C07D317/66 , C07D317/68 , C07D333/24 , C07D405/12 , C07D521/00 , C07D217/04 , C07D233/54 , C07D295/14 , C07D307/32 , C07D307/80
CPC classification number: C07D249/08 , C07C257/18 , C07C259/18 , C07C271/22 , C07C271/30 , C07C271/66 , C07C275/40 , C07C311/13 , C07C311/16 , C07C323/56 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07D207/08 , C07D209/08 , C07D213/58 , C07D213/74 , C07D215/38 , C07D217/02 , C07D231/12 , C07D231/40 , C07D231/56 , C07D233/56 , C07D237/20 , C07D239/34 , C07D239/42 , C07D239/545 , C07D241/18 , C07D241/20 , C07D261/14 , C07D263/32 , C07D277/34 , C07D277/42 , C07D295/088 , C07D303/46 , C07D307/16 , C07D307/18 , C07D307/54 , C07D307/64 , C07D317/68 , C07D333/24 , C07D405/12
Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
Abstract translation: 具有式（I）的化合物是尿激酶的抑制剂，可用于治疗尿激酶起作用的疾病。 还公开了尿激酶抑制组合物和抑制哺乳动物尿激酶的方法。
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公开(公告)号：WO2008133753A3
公开(公告)日：2008-12-24
申请号：PCT/US2007088027
申请日：2007-12-19
Applicant: ABBOTT LAB , BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
Inventor： BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
CPC classification number: C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
Abstract translation: 公开了有效抑制丙型肝炎病毒（HCV）或其他病毒复制的化合物。 本发明还涉及包含此类化合物的组合物，这类化合物与其它抗病毒剂或治疗剂的共配制或共同施用，用于合成这些化合物的方法和中间体，以及使用此类化合物治疗HCV或 其他病毒感染。
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Patent Agency Ranking
公开(公告)号：WO2007076034A3
公开(公告)日：2007-10-04
申请号：PCT/US2006049079
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：EP2094276A4
公开(公告)日：2011-01-05
申请号：EP07874373
申请日：2007-12-19
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
IPC: A61K31/675 , C07D487/14
CPC classification number: C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
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公开(公告)号：WO2010111436A3
公开(公告)日：2011-04-07
申请号：PCT/US2010028560
申请日：2010-03-25
Applicant: ABBOTT LAB , BETEBENNER DAVID A , PRATT JOHN K , DEGOEY DAVID A , DONNER PAMELA L , FLENTGE CHARLES A , HUTCHINSON DOUGLAS K , KATI WARREN M , KRUEGER ALLAN C , LONGENECKER KENTON L , MARING CLARENCE J , RANDOLPH JOHN T , ROCKWAY TODD W , TUFANO MICHAEL D , WAGNER ROLF
Inventor： BETEBENNER DAVID A , PRATT JOHN K , DEGOEY DAVID A , DONNER PAMELA L , FLENTGE CHARLES A , HUTCHINSON DOUGLAS K , KATI WARREN M , KRUEGER ALLAN C , LONGENECKER KENTON L , MARING CLARENCE J , RANDOLPH JOHN T , ROCKWAY TODD W , TUFANO MICHAEL D , WAGNER ROLF
IPC: C07C15/58 , A61K31/4412 , A61K31/513 , A61P31/14 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/74 , C07D239/10 , C07D239/54 , C07D263/22 , C07D275/02 , C07D403/10 , C07D405/10 , C07D409/10
CPC classification number: C07D409/10 , A61K31/18 , A61K31/27 , A61K31/402 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/4418 , A61K31/503 , A61K31/513 , A61K45/06 , C07C311/08 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/72 , C07D239/10 , C07D239/54 , C07D263/22 , C07D263/24 , C07D275/02 , C07D403/10 , C07D405/10 , Y02P20/55
Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。
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公开(公告)号：WO2010144646A2
公开(公告)日：2010-12-16
申请号：PCT/US2010038077
申请日：2010-06-10
Applicant: ABBOTT LAB , DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , SOLTWEDEL TODD N , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , LIU DACHUN , PRATT JOHN K , LAVIN MICHAEL J , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE
Inventor： DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , SOLTWEDEL TODD N , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , LIU DACHUN , PRATT JOHN K , LAVIN MICHAEL J , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE
IPC: C07D403/14
CPC classification number: C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
Abstract translation: 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号：WO2007081517A8
公开(公告)日：2007-09-20
申请号：PCT/US2006048685
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D495/04 , C07D471/04 , C07D513/04
CPC classification number: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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