公开(公告)号：HK1040985A1

公开(公告)日：2002-06-28

申请号：HK02102655

申请日：2002-04-09

Applicant: ABBOTT LAB

Inventor： LINK JAMES ,  LIU GANG ,  PEI ZHONGHUA ,  GELDERN VON THOMAS W ,  WINN MARTIN ,  XIN ZHILI ,  WANG SHELDON ,  BOYD STEVEN A ,  ZHU GUI-DONG ,  FREEMAN JENNIFER C ,  GUNAWARDANA INDRANI W ,  STAEGER MICHAEL A ,  JAE HWAN-SOO ,  LYNCH JOHN K

IPC: C07D243/08 ,  A61K20060101 ,  A61K31/10 ,  A61K31/165 ,  A61K31/33 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/417 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/472 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61P20060101 ,  A61P29/00 ,  A61P37/06 ,  C07C20060101 ,  C07C323/60 ,  C07C323/62 ,  C07D20060101 ,  C07D205/04 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D207/273 ,  C07D209/08 ,  C07D209/12 ,  C07D211/20 ,  C07D211/22 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D211/64 ,  C07D211/66 ,  C07D211/70 ,  C07D213/40 ,  C07D213/74 ,  C07D213/81 ,  C07D215/24 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D233/61 ,  C07D239/42 ,  C07D241/04 ,  C07D241/24 ,  C07D257/04 ,  C07D279/12 ,  C07D295/18 ,  C07D295/185 ,  C07D295/20 ,  C07D295/205 ,  C07D295/22 ,  C07D295/26 ,  C07D307/24 ,  C07D307/52 ,  C07D307/68 ,  C07D317/58 ,  C07D317/66 ,  C07D319/18 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D471/20 ,  C07D487/04 ,  C07D491/113 ,  C07D521/00 ,  C07C ,  C07D ,  A61K ,  A61P

Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.

公开(公告)号：GR900100396A

公开(公告)日：1991-10-10

申请号：GR90100396

申请日：1990-05-23

Applicant: ABBOTT LAB

Inventor： LUCAS SCOTT D ,  DAVIDSON STEVEN K ,  GELDERN VON THOMAS W ,  ROCKWAY TODD W ,  THOMAS MITCHELL A

IPC: A61K38/00 ,  A61K38/22 ,  A61P7/10 ,  A61P9/12 ,  C07K7/08 ,  C07K14/575 ,  C07K14/58 ,  A61K37/02 ,  A61K37/24

Abstract: The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R is a sulfur-containing group; R is a hydrophobic amino acid or dipeptide; R is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R is a hydrophobic amino acid; R is a peptide of up to three amino acids; R is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R is a sulfur-containing group.