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公开(公告)号：US3720768A
公开(公告)日：1973-03-13
申请号：US3720768D
申请日：1971-11-22
Applicant: ABBOTT LAB
IPC: A61K31/445 , C07D213/89 , C07D241/18 , A61K27/00
CPC classification number: C07D213/89 , A61K31/445 , C07D241/18
Abstract: METHOD OF TREATING HYPERTENSION BY ADMINISTERING TO A HYPERTENSIVE PATIENT A THERAPWUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF THE FORMULA
O=N
HO-N
WHEREIN X IIS C OR N; AND R1, R2, R3 AND R4 EACH ARE HYDROGEN, ALKYL, CYCLOALKYL OR ARYL, WITH THE LIMITATION THAT R4 IS PRESENT ONLY WHEN X IS C.-
公开(公告)号：ZA765510B
公开(公告)日：1977-08-31
申请号：ZA765510
申请日：1976-09-14
Applicant: ABBOTT LAB
IPC: A61K31/41 , A61K31/19 , A61P9/12 , C07C45/46 , C07C45/67 , C07C49/84 , C07C51/00 , C07C59/125 , C07C59/90 , C07C67/00 , C07C205/45 , C07D257/04 , C07D
Abstract: This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is -CH2COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.
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Patent Agency Ranking
公开(公告)号：PH12894A
公开(公告)日：1979-10-04
申请号：PH18922
申请日：1976-09-17
Applicant: ABBOTT LAB
IPC: A61K31/41 , A61K31/19 , A61P9/12 , C07C45/46 , C07C45/67 , C07C49/84 , C07C51/00 , C07C59/125 , C07C59/90 , C07C67/00 , C07C205/45 , C07D257/04 , C07C59/26
Abstract: This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is -CH2COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.
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公开(公告)号：PH12327A
公开(公告)日：1979-01-16
申请号：PH15681
申请日：1974-04-01
Applicant: ABBOTT LAB
IPC: C07C37/055 , C07D213/30 , C07D213/50 , C07D311/80 , C07D311/94 , C07D311/00
Abstract: 1459564 Derivatives of dibenzopyran and cyclopentabenzopyran ABBOTT LABORATORIES 1 April 1974 [2 April 1973 13 Feb 1974] 14404/74 Heading C2C The invention comprises compounds of formulµ and the pharmaceutically acceptable salts of (I), (II) and (III), wherein n is 1 or 2; R and R 1 are each H or C 1-6 alkyl [but in the pyrone compound (XIII), H or Me]; R 2 is C 1-6 alkyl; Y is C 1-10 alkylene; R 4 , R 5 , R 6 are each H, halogen, CF 3 or C 1-6 alkyl; and Z is C or N. In examples, (XIII) are prepared by reacting an ethyl cyclopentanone (or cyclohexanone)-2-carboxylate with an appropriate 5-aralkylresorcinol (A), and converted into (I) and (II) by reaction with R 2 MgBr, followed optionally by hydrogenation to give (III). Starting materials prepared are the dimethyl ethers of (A), the benzene compounds where Q is CH : CHCO 2 H, CH 2 CH 2 CO 2 H, (CH 2 ) 3 OH, (CH 2 ) 3 Br, (CH 2 ) 5 OH and (CH 2 ) 3 Br, and the compounds 3,5-(MeO) 2 C 6 H 3 CR 0 R 0 - alkylene-Ar where CR 0 R 0 is CO or one R‹ is Me and the other is OH, and Ar is R 4 R 5 R 6 C 5 HZ-. Therapeutic compositions for oral, parenteral or rectal administration comprise the above compounds (Ia), which are analgesics, mild tranquillizers and antidiarrhoeals.
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公开(公告)号：ZA7605510B
公开(公告)日：1977-08-31
申请号：ZA7605510
申请日：1976-09-14
Applicant: ABBOTT LAB
IPC: A61K31/19 , A61K31/41 , A61P9/12 , C07C45/46 , C07C45/67 , C07C49/84 , C07C51/00 , C07C59/125 , C07C59/90 , C07C67/00 , C07C205/45 , C07D257/04 , C07D
CPC classification number: C07D257/04 , C07C45/46 , C07C45/673 , C07C49/84 , C07C59/90 , C07C205/45 , Y10S514/869 , C07C49/83
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公开(公告)号：ZA741535B
公开(公告)日：1975-02-26
申请号：ZA741535
申请日：1974-03-08
Applicant: ABBOTT LAB
IPC: C07D7/02
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公开(公告)号：ZA7401535B
公开(公告)日：1975-02-26
申请号：ZA7401535
申请日：1974-03-08
Applicant: ABBOTT LAB
IPC: C07D7/02
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