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    2.
    发明专利
    未知

    公开(公告)号：SE413244B

    公开(公告)日：1980-05-12

    申请号：SE7404386

    申请日：1974-04-01

    Applicant: ABBOTT LAB

    Inventor： WINN M ,  LYNN K R ,  MARTIN Y C

    IPC: C07C37/055 ,  C07D213/30 ,  C07D213/50 ,  C07D311/80 ,  C07D311/94 ,  C07D407/06

    Abstract: 1459564 Derivatives of dibenzopyran and cyclopentabenzopyran ABBOTT LABORATORIES 1 April 1974 [2 April 1973 13 Feb 1974] 14404/74 Heading C2C The invention comprises compounds of formulµ and the pharmaceutically acceptable salts of (I), (II) and (III), wherein n is 1 or 2; R and R 1 are each H or C 1-6 alkyl [but in the pyrone compound (XIII), H or Me]; R 2 is C 1-6 alkyl; Y is C 1-10 alkylene; R 4 , R 5 , R 6 are each H, halogen, CF 3 or C 1-6 alkyl; and Z is C or N. In examples, (XIII) are prepared by reacting an ethyl cyclopentanone (or cyclohexanone)-2-carboxylate with an appropriate 5-aralkylresorcinol (A), and converted into (I) and (II) by reaction with R 2 MgBr, followed optionally by hydrogenation to give (III). Starting materials prepared are the dimethyl ethers of (A), the benzene compounds where Q is CH : CHCO 2 H, CH 2 CH 2 CO 2 H, (CH 2 ) 3 OH, (CH 2 ) 3 Br, (CH 2 ) 5 OH and (CH 2 ) 3 Br, and the compounds 3,5-(MeO) 2 C 6 H 3 CR 0 R 0 - alkylene-Ar where CR 0 R 0 is CO or one R‹ is Me and the other is OH, and Ar is R 4 R 5 R 6 C 5 HZ-. Therapeutic compositions for oral, parenteral or rectal administration comprise the above compounds (Ia), which are analgesics, mild tranquillizers and antidiarrhoeals.

    4.
    发明专利
    未知

    公开(公告)号：SE422685B

    公开(公告)日：1982-03-22

    申请号：SE7611379

    申请日：1976-10-13

    Applicant: ABBOTT LAB

    Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

    IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

    Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

    9.
    发明专利
    未知

    公开(公告)号：SE8008533L

    公开(公告)日：1980-12-04

    申请号：SE8008533

    申请日：1980-12-04

    Applicant: ABBOTT LAB

    Inventor： WINN M ,  KYNCL J ,  DUNNINGAN D A ,  JONES P H

    IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

    Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

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