公开(公告)号：DK1037886T3

公开(公告)日：2003-08-25

申请号：DK98963082

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：PT1037886E

公开(公告)日：2003-09-30

申请号：PT98963082

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：HU0202076A2

公开(公告)日：2002-11-28

申请号：HU0202076

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： DAVIDSON DONALD J ,  HENKIN JACK ,  MCCROSKEY RICHARD W ,  SHEPPARD GEORGE S ,  WOODS KEITH W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：PL344861A1

公开(公告)日：2001-11-19

申请号：PL34486198

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：SK8662000A3

公开(公告)日：2001-01-18

申请号：SK8662000

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：AU1818599A

公开(公告)日：1999-07-05

申请号：AU1818599

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：CA2313776A1

公开(公告)日：1999-06-24

申请号：CA2313776

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  HENKIN JACK ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：ES2198088T3

公开(公告)日：2004-01-16

申请号：ES98963082

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：AT239012T

公开(公告)日：2003-05-15

申请号：AT98963082

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVIDSON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：BR9813468A

公开(公告)日：2001-11-13

申请号：BR9813468

申请日：1998-12-11

Applicant: ABBOTT LAB

Inventor： HENKIN JACK ,  DAVISON DONALD J ,  SHEPPARD GEORGE S ,  WOODS KEITH W ,  MCCROSKEY RICHARD W

IPC: A61K31/53 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D413/10 ,  C07D417/04 ,  C07D453/02

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.