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1.发明申请
公开(公告)号：WO9957098A3
公开(公告)日：2000-07-27
申请号：PCT/US9909641
申请日：1999-04-30
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , HENKIN JACK , KAWAI MEGUMI , LYNCH LINDA LIJEWSKI , PATEL JYOTI , SHEPPARD GEORGE S , WANG JIEYI
IPC: C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07D207/26 , C07D207/27 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/40 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38 , C07D521/00 , A61K31/16
CPC classification number: C07D207/27 , C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2603/74 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/12 , C07D231/40 , C07D233/56 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D249/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38
Abstract: A class of substituted beta -amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
Abstract translation: 一类取代的β-氨基酸是甲硫氨酸氨基肽酶2（MetAP2）的有效抑制剂，因此可用于抑制血管发生和疾病状况，其依赖于血管生成发展，例如糖尿病性视网膜病变，肿瘤生长和炎症状况。 还公开了含有化合物的药物化合物和抑制甲硫氨酸氨基肽酶-2的方法和血管发生。
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2.发明申请ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY 审中-公开抗生素药物治疗癌症，ARTHRITIS和RETINOPATHY
公开(公告)号：WO9961406A3
公开(公告)日：2000-01-27
申请号：PCT/US9911309
申请日：1999-05-21
Applicant: ABBOTT LAB
Inventor： KAWAI MEGUMI , HENKIN JACK , SHEPPARD GEORGE S , CRAIG RICHARD A
IPC: C07D213/82 , A61K31/196 , A61K31/198 , A61K31/223 , A61K31/245 , A61K31/4406 , A61P27/02 , A61P29/02 , A61P35/00 , C07C237/22 , C07C237/42 , C07C311/45 , C07C311/46 , A61K31/195
CPC classification number: C07C237/22 , C07C311/46
Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
Abstract translation: 具有式（I）的化合物或其药学上可接受的盐或前药可用于治疗由血管生成引起或加剧的病理状态。 本发明还涉及包含这些化合物的药物组合物和抑制哺乳动物血管生成的方法。
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公开(公告)号：EP0574494A4
公开(公告)日：1994-07-06
申请号：EP92906944
申请日：1992-02-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , SHEPPARD GEORGE S , PHILLIPS JAMES G , PIREH DAISY , STEINMAN DOUGLAS H , MAY PAUL D , GUINN DENISE E , HEYMAN H ROBIN , CARRERA GEORGE M JR , DAVIDSEN STEVEN K
IPC: A61K31/44 , A61K31/4427 , A61K31/4433 , A61P7/02 , A61P11/00 , A61P29/00 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14
CPC classification number: C07D409/14 , C07D417/14
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公开(公告)号：EP0595924A4
公开(公告)日：1994-08-24
申请号：EP92915895
申请日：1992-07-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , DAVIDSEN STEVEN K , HOLMS JAMES H , PIREH DAISY , HEYMAN H ROBIN , MARTIN MICHAEL B , STEINMAN DOUGLAS H , SHEPPARD GEORGE S , CARRERA GEORGE M JR
IPC: A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
CPC classification number: C07D487/04 , A61K49/06 , C07D213/69 , C07D513/04
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公开(公告)号：CA2778265A1
公开(公告)日：2011-05-05
申请号：CA2778265
申请日：2010-10-18
Applicant: ABBOTT LAB
Inventor： BA-MAUNG NWE Y , CLARK RICHARD F , ERICKSON SCOTT A , FIDANZE STEVE D , KAWAI MEGUMI , MANTEI ROBERT A , SHEPPARD GEORGE S , SORENSON BRYAN K , WANG GARY T
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula (I).
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Patent Agency Ranking
公开(公告)号：DK1080070T3
公开(公告)日：2007-02-26
申请号：DK99924434
申请日：1999-05-21
Applicant: ABBOTT LAB
Inventor： KAWAI MEGUMI , HENKIN JACK , SHEPPARD GEORGE S , CRAIG RICHARD A
IPC: C07C237/42 , C07D213/82 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/223 , A61K31/245 , A61K31/4406 , A61P27/02 , A61P29/02 , A61P35/00 , C07C237/22 , C07C311/45 , C07C311/46
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公开(公告)号：AT346036T
公开(公告)日：2006-12-15
申请号：AT99924434
申请日：1999-05-21
Applicant: ABBOTT LAB
Inventor： KAWAI MEGUMI , HENKIN JACK , SHEPPARD GEORGE S , CRAIG RICHARD A
IPC: C07D213/82 , A61K31/196 , A61K31/198 , A61K31/223 , A61K31/245 , A61K31/4406 , A61P27/02 , A61P29/02 , A61P35/00 , C07C237/22 , C07C237/42 , C07C311/45 , C07C311/46 , A61K31/195
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公开(公告)号：DK1037886T3
公开(公告)日：2003-08-25
申请号：DK98963082
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： HENKIN JACK , DAVIDSON DONALD J , SHEPPARD GEORGE S , WOODS KEITH W , MCCROSKEY RICHARD W
IPC: A61K31/53 , A61P27/02 , A61P35/00 , A61P43/00 , C07D251/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/10 , C07D407/04 , C07D407/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/10 , C07D417/04 , C07D453/02
Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
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公开(公告)号：PE20011222A1
公开(公告)日：2001-12-07
申请号：PE2001000340
申请日：2001-04-11
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , PATEL JYOTI R , KAWAI MEGUMI , BA-MAUNG NWE Y , WANG JIEYI , LYNCH LINDA M , SHEPPARD GEORGE S , YANG FAN
IPC: C07D295/14 , A61K31/15 , A61K31/164 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/4402 , A61K31/4409 , A61K31/455 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/5375 , A61P9/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C239/20 , C07C243/28 , C07C243/34 , C07C243/38 , C07C251/86 , C07C255/42 , C07C255/66 , C07C259/06 , C07C281/02 , C07C281/06 , C07C311/37 , C07C311/38 , C07C321/14 , C07C323/12 , C07C323/18 , C07C323/41 , C07C323/60 , C07C323/62 , C07D207/34 , C07D207/40 , C07D207/416 , C07D207/50 , C07D209/20 , C07D211/12 , C07D211/62 , C07D213/38 , C07D213/54 , C07D213/75 , C07D213/77 , C07D213/86 , C07D213/87 , C07D215/42 , C07D215/46 , C07D231/14 , C07D231/38 , C07D237/14 , C07D237/20 , C07D237/24 , C07D239/28 , C07D239/42 , C07D241/24 , C07D241/44 , C07D261/18 , C07D277/20 , C07D277/36 , C07D277/56 , C07D277/82 , C07D295/15 , C07D295/20 , C07D295/32 , C07D307/24 , C07D307/56 , C07D307/68 , C07D307/85 , C07D311/04 , C07D317/68 , C07D319/08 , C07D333/38 , C07D333/40 , C07D333/68 , C07D333/72
Abstract: SE REFIERE A HIDRAZIDAS Y ALCOXIAMIDAS DE FORMULA I DONDE R1 ES ALQUILO, ARILO, ARILALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, ARILALQUILO; R4 ES NR6R7, OR8; R6 Y R7 SON H, ALCANOILO, ALQUENILO, ALQUENILOXIALQUILO, ALCOXIALQUILO, ALCOXICARBONILO, ENTRE OTROS; R6 Y R7 JUNTOS FORMAN ARILALQUILIDENO; R8 ES H, ALCANOILALQUILO, ALQUENILO, ALCOXICARBONILALQUILO, ALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (2RS,3R)-3-AMINO-4-CICLOHEXIL-2-HIDROXI-N-FENOXIBUTANAMIDA, (2RS,3R)-3-AMINO-N-(BENCILOXI)-4-CICLOHEXIL-2-HIDROXIBUTANAMIDA,(2RS,3R)-3-AMINO-N-(METOXI)-4-CICLOHEXIL-2-HIDROXIBUTANAMIDA,N'-((2RS,3R)-3-AMINO-4-CICLOHEXIL-2-HIDROXIBUTANOIL)-1-NAFTOHIDRAZIDA, ENTRE OTROS. LOS COMPUESTOS DE HIDRAZIDAS Y ALCOXIAMIDAS SON INHIBIDORES DE LA METIONINA AMINOPEPTIDASA TIPO 2 (MetAP2) Y SON UTILES PARA INHIBIR LA ANGIOGENESIS
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公开(公告)号：PE12222001A1
公开(公告)日：2001-12-07
申请号：PE0003402001
申请日：2001-04-11
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , PATEL JYOTI R , KAWAI MEGUMI , BA-MAUNG NWE Y , WANG JIEYI , LYNCH LINDA M , SHEPPARD GEORGE S , YANG FAN
IPC: C07D295/14 , A61K31/15 , A61K31/164 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/4402 , A61K31/4409 , A61K31/455 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/5375 , A61P9/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C239/20 , C07C243/28 , C07C243/34 , C07C243/38 , C07C251/86 , C07C255/42 , C07C255/66 , C07C259/06 , C07C281/02 , C07C281/06 , C07C311/37 , C07C311/38 , C07C321/14 , C07C323/12 , C07C323/18 , C07C323/41 , C07C323/60 , C07C323/62 , C07D207/34 , C07D207/40 , C07D207/416 , C07D207/50 , C07D209/20 , C07D211/12 , C07D211/62 , C07D213/38 , C07D213/54 , C07D213/75 , C07D213/77 , C07D213/86 , C07D213/87 , C07D215/42 , C07D215/46 , C07D231/14 , C07D231/38 , C07D237/14 , C07D237/20 , C07D237/24 , C07D239/28 , C07D239/42 , C07D241/24 , C07D241/44 , C07D261/18 , C07D277/20 , C07D277/36 , C07D277/56 , C07D277/82 , C07D295/15 , C07D295/20 , C07D295/32 , C07D307/24 , C07D307/56 , C07D307/68 , C07D307/85 , C07D311/04 , C07D317/68 , C07D319/08 , C07D333/38 , C07D333/40 , C07D333/68 , C07D333/72
CPC classification number: C07D207/416 , C07B2200/07 , C07C243/34 , C07C243/38 , C07C251/86 , C07C255/42 , C07C255/66 , C07C259/06 , C07C281/02 , C07C281/06 , C07C311/38 , C07C323/41 , C07C323/60 , C07C323/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/50 , C07D209/20 , C07D211/12 , C07D211/62 , C07D213/38 , C07D213/54 , C07D213/77 , C07D213/86 , C07D215/42 , C07D231/14 , C07D231/38 , C07D237/14 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/44 , C07D261/18 , C07D277/36 , C07D277/56 , C07D277/82 , C07D295/15 , C07D295/32 , C07D307/24 , C07D307/68 , C07D317/68 , C07D333/38 , C07D333/68 , C07D333/72
Abstract: SE REFIERE A HIDRAZIDAS Y ALCOXIAMIDAS DE FORMULA I DONDE R1 ES ALQUILO, ARILO, ARILALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, ARILALQUILO; R4 ES NR6R7, OR8; R6 Y R7 SON H, ALCANOILO, ALQUENILO, ALQUENILOXIALQUILO, ALCOXIALQUILO, ALCOXICARBONILO, ENTRE OTROS; R6 Y R7 JUNTOS FORMAN ARILALQUILIDENO; R8 ES H, ALCANOILALQUILO, ALQUENILO, ALCOXICARBONILALQUILO, ALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (2RS,3R)-3-AMINO-4-CICLOHEXIL-2-HIDROXI-N-FENOXIBUTANAMIDA, (2RS,3R)-3-AMINO-N-(BENCILOXI)-4-CICLOHEXIL-2-HIDROXIBUTANAMIDA,(2RS,3R)-3-AMINO-N-(METOXI)-4-CICLOHEXIL-2-HIDROXIBUTANAMIDA,N'-((2RS,3R)-3-AMINO-4-CICLOHEXIL-2-HIDROXIBUTANOIL)-1-NAFTOHIDRAZIDA, ENTRE OTROS. LOS COMPUESTOS DE HIDRAZIDAS Y ALCOXIAMIDAS SON INHIBIDORES DE LA METIONINA AMINOPEPTIDASA TIPO 2 (MetAP2) Y SON UTILES PARA INHIBIR LA ANGIOGENESIS
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