公开(公告)号：IE73236B1

公开(公告)日：1997-05-21

申请号：IE921045

申请日：1992-04-02

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：IE921045A1

公开(公告)日：1992-10-21

申请号：IE921045

申请日：1992-04-02

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：ES2115760T3

公开(公告)日：1998-07-01

申请号：ES93904533

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：AT164848T

公开(公告)日：1998-04-15

申请号：AT93904533

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：ES2091471T3

公开(公告)日：1996-11-01

申请号：ES92911585

申请日：1992-03-30

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：DE69211845D1

公开(公告)日：1996-08-01

申请号：DE69211845

申请日：1992-03-30

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：DE69317877D1

公开(公告)日：1998-05-14

申请号：DE69317877

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：DK0579770T3

公开(公告)日：1996-11-04

申请号：DK92911585

申请日：1992-03-30

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：AU663089B2

公开(公告)日：1995-09-28

申请号：AU1910392

申请日：1992-03-30

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08 ,  A61K31/71

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：MX9300278A

公开(公告)日：1993-12-31

申请号：MX9300278

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  FAGHIH RAMIN ,  KLEIN LARRY L ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.