公开(公告)号：NZ591609A

公开(公告)日：2012-10-26

申请号：NZ59160906

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHAU ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES

IPC: C07D317/64 ,  A61K31/135 ,  A61K31/137 ,  C07C211/40 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D487/04

Abstract: Disclosed are trans-6-(phenyl)cyclohex-3-en-1-amine / trans-2-(phenyl)cyclohex-4-enyl-amine derivatives as represented by the general formula (I), wherein the substituents are as disclosed herein. Representative compounds include trans-6-(2-chlorophenyl)cyclohex-3-en-1-amine, trans-6-(2,4-dichlorophenyl)cyclohex-3-enyl-amine, 4-{ [trans-5-amino-4-(2,4-dichlorophenyl)-2-pyridin-3-ylcyclohex-1 -en-1-yl]methoxy} benzonitrile, trans-methyl 3-{ { 5-amino-4-(2,4-dichlorophenyl)-2-pyridin-3-ylcyclohex-1-en-1-yl]methoxy} benzoate, trans-3-(phenoxymethyl)-6-(2,4,5-trifluorophenyl)cyclohex-3-en-1-amine, trans-3-{ [4-(methylsulfonyI)phenoxy] methyl} -6-(2,4,5-trifluorophenyl)cyclohex-3-en-1-amine, N-(3-{ [trans-5-amino-4-(2,4,5-trifluorophenyl)cyclohex-1-en-1-yl)methoxy } phenyl)acetamide, 3-{ [trans-5-amino-4-(2,4,5-trifluorophenyl)cyclohex-1-en-1-yl]methoxy} -4-fluorobenzoic acid, trans-3-{ [3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl} -6-(2,4,5-trifluorophenyl)cyclohex-3-en-1-amine and trans-3-[(4-acetylpiperazin-1-yI)methyl]-6-(2,4,5-trifluorophenyl)cyclohex -3-en-1-amine. Further disclosed is a pharmaceutical composition which comprises a therapeutically effective amount of a compound as defined above, in combination with a pharmaceutically suitable carrier for the treatment of diseases selected from the group consisting of cardiovascular disease, atherosclerosis, cerebrovascular diseases, diseases and disorders of the central nervous system, schizophrenia, anxiety, bipolar disease, depression, insomnia, cognitive disorders, gastrointestinal diseases and disorders, cancer, inflammation and inflammatory diseases, respiratory diseases and disorders, musculo-skeletal disorders, osteoporosis, menopausal symptoms, periodontal diseases, gingivitis, and various immunomodulatory diseases.