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    Substituted benzopyranopyrrole and benzopyranopyridine derivatives
    5.
    发明专利
    Substituted benzopyranopyrrole and benzopyranopyridine derivatives 未知

    公开(公告)号：NZ335711A

    公开(公告)日：2000-10-27

    申请号：NZ33571197

    申请日：1997-12-04

    Applicant: ABBOTT LAB

    Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANG WEIJIANG

    IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415 ,  C07D495/14 ,  C07D207/38 ,  A61K31/505

    Abstract: The benzopyranopyrrole and benzopyranopyridine derivatives or a pharmaceutically acceptable salt or prodrug thereof have the formula I wherein: R1 and R2 are independently hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino or aminoalkyl; A is methylene; n is 1 or 2; W is C2-10 alkylene; R3 is a group of formula 2; G is and G' are independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulphonyl or aminoalkyl; Y and Y' are independently oxygen, nitrogen or sulphur provided that when Y is O or S then G is absent and when Y' is O or S then G' is absent; V and V' are independently nitrogen or methine and U is a ring that is fused to its adjacent ring and is: (a) an optionally substituted five member ring having five carbon atoms; (b) an optionally substituted five membered ring having four carbon atoms and one heteroatom being nitrogen, oxygen or sulphur; (c) an optionally substituted five membered ring having three carbon atoms and two heteroatoms independently being nitrogen, oxygen or sulphur; (d) an optionally substituted six membered ring having six carbon atoms; (e) an optionally substituted six membered ring having 5 carbon atoms and one heteroatom being nitrogen, oxygen or sulphur; (f) an optionally substituted 6 membered ring having 4 carbon atoms and two heteroatom independently being nitrogen, oxygen or sulphur or (g) an optionally substituted 6 membered ring having three carbon atoms and three heteroatoms independently being nitrogen, oxygen or sulphur. A pharmaceutical composition thereof is useful for antagonizing a-1-adrenoreceptors or for treating benign prostatic hyperplasia, bladder outlet obstruction, neurogenic bladder or uterine smooth muscle contraction in a mammal. Intermediates of formulae XV, XVI, XVII, XVIII, XIX, XX, XXI, XXII, XXIII, XXIV, XXV, XXVI, XXVII, XXVIII and XXIX are disclosed wherein: U, Y', G', R1 and R2 are as defined above; m is 2 to 10; X is halogen; R' is alkyl or arylalkyl; R is alkyl; Rz is alkyl and n is 0 or 1.

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