公开(公告)号：JP2013136605A

公开(公告)日：2013-07-11

申请号：JP2013024289

申请日：2013-02-12

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： WERNET WOLFGANG ,  PENNING THOMAS D ,  GIRANDA VINCENT L

IPC: A61K31/4184 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00

CPC classification number: C07D403/04 ,  A61K31/41 ,  A61K31/4164 ,  A61K41/0038 ,  A61K45/06 ,  A61N2005/1098 ,  A61K2300/00

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition of a PARP inhibitor shown to potentiate radiotherapy and chemotherapy by increasing apoptosis of cancer cells, limiting tumor growth, decreasing metastasis, and prolonging the survival of tumor-bearing animals.SOLUTION: The invention describes benzimidazole derivatives which constitute potent PARP inhibitors which is 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide, or a therapeutically acceptable salt thereof used in combination with radiotherapy, or in combination with other chemotherapeutic agents.

Abstract translation: 要解决的问题：提供一种PARP抑制剂的药物组合物，其通过增加癌细胞的凋亡，限制肿瘤生长，减少转移和延长荷瘤动物的存活来增强放射治疗和化学疗法。解决方案：本发明描述了苯并咪唑 构成有效的PARP抑制剂的衍生物，其是2 - [（2R）-2-甲基吡咯烷-2-基] -1H-苯并咪唑-4-甲酰胺或其与放射治疗组合使用的治疗可接受的盐，或与其他化学治疗剂 代理商

公开(公告)号：WO2009012280A2

公开(公告)日：2009-01-22

申请号：PCT/US2008070113

申请日：2008-07-16

Applicant: ABBOTT LAB ,  GANDHI VIRAJKUMAR B ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  PENNING THOMAS D ,  ZHU GUI-DONG

Inventor： GANDHI VIRAJKUMAR B ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  PENNING THOMAS D ,  ZHU GUI-DONG

IPC: C07D417/14 ,  A61K31/427 ,  A61P35/00

CPC classification number: C07D417/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.

Abstract translation: 公开了抑制聚（ADP-核糖）聚合酶（PARP）活性的化合物，含有该化合物的组合物和使用它们治疗疾病的方法。

公开(公告)号：WO2007149907A3

公开(公告)日：2008-02-07

申请号：PCT/US2007071649

申请日：2007-06-20

Applicant: ABBOTT LAB ,  PENNING THOMAS D ,  THOMAS SHEELA A ,  HAJDUK PHILIP J ,  SAUER DARYL R ,  SARRIS KATHY ,  GIRANDA VINCENT L

Inventor： PENNING THOMAS D ,  THOMAS SHEELA A ,  HAJDUK PHILIP J ,  SAUER DARYL R ,  SARRIS KATHY ,  GIRANDA VINCENT L

IPC: C07D487/04 ,  A61K31/519

CPC classification number: C07D487/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。

公开(公告)号：WO2008082839A3

公开(公告)日：2009-01-29

申请号：PCT/US2007086472

申请日：2007-12-05

Applicant: ABBOTT LAB ,  PENNING THOMAS D ,  HASVOLD LISA A ,  HEXAMER LAURA A ,  GIRANDA VINCENT L ,  LIN NAN-HORNG ,  TAO ZHI-FU ,  WANG LE

Inventor： PENNING THOMAS D ,  HASVOLD LISA A ,  HEXAMER LAURA A ,  GIRANDA VINCENT L ,  LIN NAN-HORNG ,  TAO ZHI-FU ,  WANG LE

IPC: A61K31/519 ,  A61P43/00 ,  C07D495/04

CPC classification number: C07D495/04

Abstract: Thieno[3,2-d]pyrimidiii-4-one derivatives as inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.

Abstract translation: 披露了噻吩并[3,2-d]嘧啶-4-酮衍生物作为Pim激酶的抑制剂，其制备方法和使用它们治疗患者的方法。

公开(公告)号：WO2008082887A3

公开(公告)日：2008-12-04

申请号：PCT/US2007087250

申请日：2007-12-12

Applicant: ABBOTT LAB ,  GIRANDA VINCENT L ,  MIYASHIRO JULIE M ,  PENNING THOMAS D ,  WOODS KEITH W

Inventor： GIRANDA VINCENT L ,  MIYASHIRO JULIE M ,  PENNING THOMAS D ,  WOODS KEITH W

IPC: C07D487/04 ,  A61K31/4188 ,  A61K31/4965 ,  A61K31/502 ,  A61K31/5513 ,  A61K31/5517 ,  C07D241/06 ,  C07D241/36 ,  C07D243/14

CPC classification number: C07D241/08 ,  C07D241/44 ,  C07D243/08 ,  C07D243/14 ,  C07D471/04 ,  C07D487/04

Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

Abstract translation: 公开了聚（ADP-核糖）聚合酶抑制剂，使其制备方法和使用它们治疗患者的方法。

公开(公告)号：EP2120579A4

公开(公告)日：2011-04-27

申请号：EP07869628

申请日：2007-12-20

Applicant: ABBOTT LAB

Inventor： GANDHI VIRAJ B ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  PENNING THOMAS D ,  ZHU GUI-DONG

IPC: A01N43/58 ,  A61K31/495 ,  A61K31/50 ,  C07D237/32 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14

CPC classification number: C07D403/10 ,  C07D237/32 ,  C07D403/12 ,  C07D403/14 ,  Y02P20/582

公开(公告)号：WO2007131016A3

公开(公告)日：2008-12-18

申请号：PCT/US2007067991

申请日：2007-05-02

Applicant: ABBOTT LAB ,  GIRANDA VINCENT L ,  PENNING THOMAS D ,  GANDHI VIRAJKUMAR B ,  THOMAS SHEELA A ,  ZHU GUI-DONG ,  GONG JIANCHUN

Inventor： GIRANDA VINCENT L ,  PENNING THOMAS D ,  GANDHI VIRAJKUMAR B ,  THOMAS SHEELA A ,  ZHU GUI-DONG ,  GONG JIANCHUN

IPC: C07D403/10

CPC classification number: C07D403/10 ,  C07D235/18 ,  C07D409/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。

公开(公告)号：WO2007084532A3

公开(公告)日：2007-09-07

申请号：PCT/US2007001189

申请日：2007-01-17

Applicant: ABBOTT LAB ,  WERNET WOLFGANG ,  PENNING THOMAS D ,  GIRANDA VINCENT L

Inventor： WERNET WOLFGANG ,  PENNING THOMAS D ,  GIRANDA VINCENT L

IPC: A61K31/41 ,  A61K31/4164 ,  A61K49/00 ,  C07D401/02 ,  C07D471/00

CPC classification number: C07D403/04 ,  A61K31/41 ,  A61K31/4164 ,  A61K41/0038 ,  A61K45/06 ,  A61N2005/1098 ,  A61K2300/00

Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.

Abstract translation: 本发明描述了式（I）的苯并咪唑衍生物，其与放射疗法或与其他化学治疗剂组合组成了有效的PARP抑制剂。

公开(公告)号：WO2007059230A2

公开(公告)日：2007-05-24

申请号：PCT/US2006044379

申请日：2006-11-15

Applicant: ABBOTT LAB ,  PENNING THOMAS D ,  THOMAS SHEELA A ,  ZHU GUI-DONG ,  GONG JIANCHUN ,  GIRANDA VINCENT L ,  GANDHI VIRAJ B

Inventor： PENNING THOMAS D ,  THOMAS SHEELA A ,  ZHU GUI-DONG ,  GONG JIANCHUN ,  GIRANDA VINCENT L ,  GANDHI VIRAJ B

CPC classification number: C07D235/18 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

Abstract translation: 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。

公开(公告)号：WO2006110816A2

公开(公告)日：2006-10-19

申请号：PCT/US2006013652

申请日：2006-04-11

Applicant: ABBOTT LAB ,  ZHU GUIDONG ,  GONG JIANCHUN ,  GANDHI VIRAJKUMAR B ,  PENNING THOMAS D ,  GIRANDA VINCENT

Inventor： ZHU GUIDONG ,  GONG JIANCHUN ,  GANDHI VIRAJKUMAR B ,  PENNING THOMAS D ,  GIRANDA VINCENT

IPC: C07D401/04 ,  A61K31/4184 ,  A61K31/454 ,  C07D403/04

CPC classification number: C07D403/04 ,  C07D207/16 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14

Abstract: Compounds of Formula (I) (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

Abstract translation: 式（I）（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。