公开(公告)号：CA2135887A1

公开(公告)日：1993-12-23

申请号：CA2135887

申请日：1993-06-09

Applicant: ABBOTT LAB

Inventor： BAKER HAROLD N ,  ENG KATHERINE K ,  GARNER WILLIAM D ,  MASSEI MICHAEL K ,  NECKLAWS ELIZABETH C ,  OSIKOWICZ EUGENE W ,  RAMP SALLY K ,  TRACH PAULA

IPC: G01N33/53 ,  C07J1/00 ,  C07J41/00 ,  C12N9/16 ,  C12N9/96 ,  G01N33/535 ,  G01N33/543 ,  G01N33/58 ,  G01N33/74 ,  C12N9/14 ,  G01N33/547

Abstract: 2135887 9325672 PCTABS00028 The present invention relates to the measurement of estradiol using competitive immunoassay methods. The inventors unexpectedly discovered that estrone and its derivatives conjugated to a label is a particularly effective tracer when used in conjunction with estradiol specific antibodies to determine estradiol levels in fluid samples. The present invention also utilizes 5.alpha.-dihydrotestosterone to enhance the assay performance.

公开(公告)号：AU1474688A

公开(公告)日：1988-10-27

申请号：AU1474688

申请日：1988-04-19

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  GRANDONE CASS J ,  RAMP SALLY K ,  OSIKOWICZ EUGENE W ,  SEBESTA EDWARD E

IPC: B01L3/00 ,  G01N33/543 ,  G01N35/02 ,  G01N21/01 ,  G01N1/28 ,  G01N33/52 ,  G01N33/53 ,  G01N33/549