公开(公告)号：CA2484087A1

公开(公告)日：2003-11-13

申请号：CA2484087

申请日：2003-04-25

Applicant: ABBOTT LAB

Inventor： DJURIC STEVAN M ,  MA ZHENKUN ,  PHAN LY ,  RUPP MICHAEL J ,  CLARK RICHARD F

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Antibacterial compounds with improved pharmacokinetic profiles having formul a (I), and salts, prodrugs, and salts of prodrugs thereof, processes for makin g the compounds and intermediates used in the processes, compositions containi ng the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：AT398627T

公开(公告)日：2008-07-15

申请号：AT00930370

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  OR YAT ,  PHAN LY ,  ZHANG SUOMING ,  CLARK RICHARD

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: A compound having the formula selected from the group consisting ofa compound of formula Ia compound of formula IIa compound of formula IIIas well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.

公开(公告)号：BG64707B1

公开(公告)日：2005-12-30

申请号：BG10443400

申请日：2000-05-15

Applicant: ABBOTT LAB

Inventor： PHAN LY ,  OR YAT SUN ,  CHU DANIEL ,  PLATTNER JACOB ,  CHEN YAN ,  CLARK RICHARD

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: The invention relates to novel 2-halo-6-O-substituted ketolide derivatives with the formula to their pharmaceutically acceptable salts having antibacterial activity, to pharmaceutical compositions comprising a therapeutically effective amount of a compound according to the invention in combination with a pharmaceutically acceptable carrier, as well as to the utilization of the compounds or their pharmaceutically acceptable salt for the preparation of a medicament for treating bacterial infections in mammals. The invention also relates to the preparation of the compounds.

公开(公告)号：AT397615T

公开(公告)日：2008-06-15

申请号：AT00982357

申请日：2000-12-01

Applicant: ABBOTT LAB

Inventor： PHAN LY ,  OR YAT ,  MA ZHENKUN

IPC: C07H17/00 ,  A61K31/7052 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08